Results 11 to 20 of about 4,889,916 (279)

Enhancers dysfunction in the 3D genome of cancer cells [PDF]

Frontiers in Cell and Developmental Biology, 2023
Eukaryotic genomes are spatially organized inside the cell nucleus, forming a threedimensional (3D) architecture that allows for spatial separation of nuclear processes and for controlled expression of genes required for cell identity specification and ...
Giulia Della Chiara, Carlos Jiménez, Mohit Virdi, Nicola Crosetto, Nicola Crosetto, Nicola Crosetto, Magda Bienko, Magda Bienko, Magda Bienko   +8 more
doaj   +2 more sources

SATB1 regulates 3D genome architecture in T cells by constraining chromatin interactions surrounding CTCF-binding sites

Cell Reports, 2023
Summary: Special AT-rich sequence binding protein 1 (SATB1) has long been proposed to act as a global chromatin loop organizer in T cells. However, the exact functions of SATB1 in spatial genome organization remain elusive.
Bao Wang, Luzhang Ji, Qian Bian
doaj   +2 more sources

Novel biological insights revealed from the investigation of multiscale genome architecture

Computational and Structural Biotechnology Journal, 2023
Gene expression and cell fate determination require precise and coordinated epigenetic regulation. The complex three-dimensional (3D) genome organization plays a critical role in transcription in myriad biological processes. A wide range of architectural
Tianyi Ding, He Zhang
doaj   +2 more sources

Three-dimensional genome architecture and emerging technologies: looping in disease

Genome Medicine, 2017
Genome compaction is a universal feature of cells and has emerged as a global regulator of gene expression. Compaction is maintained by a multitude of architectural proteins, long non-coding RNAs (lncRNAs), and regulatory DNA.
Arpit Mishra, R. David Hawkins
doaj   +2 more sources

HAdV55 reprograms host 3D genome architecture and mitochondrial metabolism to drive pathogenesis [PDF]

Cellular and Molecular Life Sciences
Human adenovirus type 55 (HAdV55), an emerging recombinant pathogen linked to severe respiratory outbreaks, exhibits heightened virulence and replication efficiency, yet its mechanisms of host interaction remain poorly resolved.
Kaiying Wang, Jinhui Li, Zixuan Chen, Ning Wang, Dingchen Li, Hao Hong, Xiong Liu, Yanfeng Lin, Qichao Chen, Peihan Li, Lang Yang, Leili Jia, Haifeng Pan, Yongqiang Jiang, Peng Li, Hongbin Song   +15 more
doaj   +2 more sources

The 3D architecture of the pepper genome and its relationship to function and evolution [PDF]

Nature Communications, 2022
The organization of chromatin into self-interacting domains is universal among eukaryotic genomes. Here, the authors report a reference-grade pepper genome assembly and use this reference to help describe the relationship among 3D chromatin conformation,
Yi Liao, Juntao Wang, Zhangsheng Zhu, Yuanlong Liu, Jinfeng Chen, Yongfeng Zhou, Feng Liu, Jianjun Lei, Brandon S. Gaut, Bihao Cao, J. J. Emerson, Changming Chen   +11 more
doaj   +6 more sources

DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity [PDF]

Cell Reports, 2021
Summary: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects ...
Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark   +23 more
doaj   +2 more sources

Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens [PDF]

Journal of Animal Science and Biotechnology
Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality rate. Three-dimensional (3D) chromatin architecture takes part in disease processing by regulating transcriptional reprogramming ...
Yanli Liu, Zhuqing Zheng, Chaohui Wang, Yumeng Wang, Xi Sun, Zhouzheng Ren, Xin Yang, Xiaojun Yang   +7 more
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Lifelong restructuring of 3D genome architecture in cerebellar granule cells. [PDF]

Science, 2023
The cerebellum contains most of the neurons in the human brain and exhibits distinctive modes of development and aging. In this work, by developing our single-cell three-dimensional (3D) genome assay—diploid chromosome conformation capture, or Dip-C—into population-scale (Pop-C) and virus-enriched (vDip-C) modes, we resolved the first 3D genome ...
Tan L, Shi J, Moghadami S, Parasar B, Wright CP, Seo Y, Vallejo K, Cobos I, Duncan L, Chen R, Deisseroth K.   +10 more
europepmc   +3 more sources

The significance of chromosome conformation capture in 3D genome architecture comprehension

Computational Biology and Chemistry
Chromosomes are intricate macromolecules composed of chromatin that create three-dimensional structures within cells. The arrangement and interactions of chromosomes play a crucial role in shaping the genome's structure, function, and gene expression regulation.
Selinay Cetin, Emre Sefer
openaire   +4 more sources