Comparative 3D genome architecture in vertebrates [PDF]
BMC Biology, 2022 Background The three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences the regulation of essential nuclear processes at the basis of gene expression, such as gene transcription.
Diyan Li +15 more
doaj +2 more sources
Folding Features and Dynamics of 3D Genome Architecture in Plant Fungal Pathogens [PDF]
Microbiology Spectrum, 2022 The folding and dynamics of three-dimensional (3D) genome organization are fundamental for eukaryotes executing genome functions but have been largely unexplored in nonmodel fungi.
Chongjing Xia +10 more
doaj +2 more sources
Mapping the 3D genome architecture [PDF]
Computational and Structural Biotechnology JournalThe spatial organization of the genome plays a critical role in regulating gene expression, cellular differentiation, and genome stability. This review provides an in-depth examination of the methodologies, computational tools, and frameworks developed ...
Ghazaleh Tavallaee, Elias Orouji
doaj +2 more sources
Bacterial 3D genome architecture: organization, regulation, and synthetic biology applications [PDF]
Genome BiologyBacterial chromosomes are compacted into hierarchical three-dimensional (3D) architectures that underpin essential processes such as replication, transcription, and segregation.
Mao Chen +4 more
doaj +2 more sources
β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture [PDF]
Nature Communications, 2021 β-actin loss can affect gene expression and heterochromatin organization. Here the authors conduct a comprehensive genomic analysis of β-actin knockout mouse embryonic fibroblasts (MEFs) to investigate the impact of changes in β-actin levels on 3d genome
Syed Raza Mahmood +5 more
doaj +2 more sources
A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth [PDF]
Nature Communications, 2023 The dynamic and temporal changes of host genome architecture during Epstein-Barr virus (EBV) transformation are not well known. Here the authors transform human primary B lymphocyte into lymphoblastoid cell lines (LCLs) with EBV and show that the host 3D
Chong Wang +21 more
doaj +2 more sources
Divergent 3D genome architecture of male germ cells across vertebrates [PDF]
Nature CommunicationsThe evolutionary plasticity of the three-dimensional (3D) genome organization in vertebrates, and its transmission through the germ line, is central to understanding genome function and evolution.
Laia Marín-Gual +10 more
doaj +2 more sources
Structural Variations of the 3D Genome Architecture in Cervical Cancer Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 Human papillomavirus (HPV) integration is the major contributor to cervical cancer (CC) development by inducing structural variations (SVs) in the human genome.
Muhammad Muzammal Adeel +16 more
doaj +2 more sources
Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis [PDF]
Frontiers in Genetics, 2023 Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS ...
Connor Davidson +7 more
doaj +2 more sources
Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes [PDF]
Nature CommunicationsThe eukaryotic nucleus exhibits a highly organized 3D genome architecture, with RNA transcription and processing confined to specific nuclear structures. While intra-chromosomal interactions, such as promoter-enhancer dynamics, are well-studied, the role
Claudia Rabuffo +10 more
doaj +2 more sources