Results 51 to 60 of about 4,889,916 (279)
BMC Plant Biology, 2023 Background The adaptation of plants to cold stress involves changes in gene expression profiles that are associated with epigenetic regulation. Although the three-dimensional (3D) genome architecture is considered an important epigenetic regulator, the ...
Xin Zhang +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The genome of a eukaryotic organism is comprised of a supra-molecular complex of chromatin fibers and intricately folded three-dimensional (3D) structures.
Suresh Kumar +4 more
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Configurable 3D-integrated focal-plane sensor-processor array architecture [PDF]
, 2008 A mixed-signal Cellular Visual Microprocessor architecture with digital processors is described. An ASIC implementation is also demonstrated. The architecture is composed of a regular sensor readout circuit array, prepared for 3D face-to-face type ...
Rekeczky, Csaba +2 more
core +1 more source
Single-Cell Analysis of the 3D Topologies of Genomic Loci Using Genome Architecture Mapping [PDF]
, 2020 Abstract Although each cell within an organism contains a nearly identical genome sequence, the three-dimensional (3D) packing of the genome varies among individual cells, influencing cell-type-specific gene expression. Genome Architecture Mapping (GAM) is the first genome-wide experimental method for capturing 3D proximities between ...
Welch, Lonnie R. +6 more
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Improved accuracy assessment for 3D genome reconstructions
BMC Bioinformatics, 2018 Background Three dimensional (3D) genome spatial organization is critical for numerous cellular functions, including transcription, while certain conformation-driven structural alterations are frequently oncogenic.
Mark R. Segal, Henrik L. Bengtsson
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
3D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies
Experimental and Molecular MedicineThe three-dimensional (3D) genome architecture is fundamental to orchestrating gene expression, safeguarding genome integrity and establishing cell-type-specific transcriptional landscapes.
Sunyoung Jang, Kyung Hyun Yoo
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Single‐cell imaging of genome organization and dynamics
Molecular Systems Biology, 2021 Probing the architecture, mechanism, and dynamics of genome folding is fundamental to our understanding of genome function in homeostasis and disease. Most chromosome conformation capture studies dissect the genome architecture with population‐ and time ...
Liangqi Xie, Zhe Liu
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