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Protocol for Effective Differentiation of 3T3-L1 Cells to Adipocytes
Analytical Biochemistry, 2012In this note, we present a detailed procedure for highly effective and reproducible 3T3-L1 cell differentiation. Due to their potential to differentiate from fibroblasts to adipocytes, 3T3-L1 cells are widely used for studying adipogenesis and the biochemistry of adipocytes. However, using different kits and protocols published so far, we were not able
Martin Wabitsch +2 more
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Novel antiadipogenic effect of menadione in 3T3-L1 cells
Chemico-Biological Interactions, 2021Inhibition of adipocyte differentiation can be used as a strategy for preventing adipose tissue expansion and, consequently, for obesity management. Since reactive oxygen species (ROS) have emerged as key modulators of adipogenesis, the effect of menadione (a synthetic form of vitamin K known to induce the increase of intracellular ROS) on 3T3-L1 ...
Melania Iara Funk +3 more
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Prostaglandin production by 3T3-L1 cells in culture
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982Rapidly growing cultures of 3T3-L1 preadipocytes produce large quantities of prostaglandins when they are either stimulated with the calcium ionophore A23187 or incubated with arachidonic acid. The main prostaglandin produced under all conditions was prostaglandin E2.
B T, Hyman, L L, Stoll, A A, Spector
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THE EFFECTS OF INTERFERON ON 3T3‐L1 CELL DIFFERENTIATION*
Annals of the New York Academy of Sciences, 1980Mouse 3T3-L1 fibroblasts, after attaining confluence, slowly differentiate functionally and morphologically into adipose cells. This conversion, characterized by a great accumulation of lipids, mostly triglycerides, is hastened by added insulin. The cells are relatively sensitive to the antiviral action of mouse fibroblast interferon (IF).
S E, Grossberg, S, Keay
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Development of lipoprotein lipase in cultured 3T3-L1 cells
Biochemical and Biophysical Research Communications, 1977Abstract The 3T3-L1 mouse fibroblast resembles an adipocyte after reaching a confluent stage of growth. Lipoprotein lipase activity was released with heparin and was present in acetone-ether extracts of these cells. During the early post-confluent period both activities increased rapidly.
R H, Eckel, W Y, Fujimoto, J D, Brunzell
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Effect of Cortisol on Calpains in the C2C12 and 3T3-L1 Cells
Applied Biochemistry and Biotechnology, 2014The present study was carried out to understand the effect of cortisol on calpain system in the C2C12 and 3T3-L1 adipocyte cells under co-culture system. Cells were co-cultured by using transwell inserts with a 0.4 μm porous membrane to separate C2C12 and 3T3-L1 preadipocyte cells.
Pandurangan, Muthuraman +3 more
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The Effects of AICAR on Adipocyte Differentiation of 3T3-L1 Cells
Biochemical and Biophysical Research Communications, 2001The AMP-activated protein kinase (AMPK) activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), has been found to inhibit the differentiation of 3T3-L1 adipocytes, if added at an early phase of differentiation. AICAR blocks the expression of the late adipogenic markers, fatty acid synthase and acetyl-CoA carboxylase, and of the transcription ...
S A, Habinowski, L A, Witters
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Adipogenetic effects of retrofractamide A derivatives in 3T3-L1 cells
Bioorganic & Medicinal Chemistry Letters, 2013In a previous study, retrofractamide A from the fruit of Piper chaba was shown to promote adipogenesis in 3T3-L1 cells. In the present study, retrofractamide A and its derivatives were synthesized, and their adipogenetic effects in 3T3-L1 cells were examined.
Ahmed Aboul-Fotouh, Mourad +11 more
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Brazilin Stimulates the Glucose Transport in 3T3-L1 Cells
Planta Medica, 1995Brazilin (7,11b-dihydrobenz[b]indeno-[1,2-d]pyran-3,6a,9,10(6H)- tetrol) was found to have hypoglycemic action and increase glucose metabolism in experimental diabetic animals. In order to investigate the mechanism of hypoglycemic action of brazilin, the effects of brazilin on glucose transport, insulin receptor autophosphorylation, and protein kinase ...
Y M, Kim, S G, Kim, L Y, Khil, C K, Moon
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Regulation of adipocyte differentiation of 3T3-L1 cells by PDZRN3
American Journal of Physiology-Cell Physiology, 2013PDZRN3, a member of the PDZRN (or LNX) family of proteins, is essential for the differentiation of mesenchymal stem cells into myotubes, but it plays an inhibitory role in the differentiation of these cells into osteoblasts. Given that mesenchymal stem cells also differentiate into adipocytes, we examined the possible role of PDZRN3 in adipogenesis in
Takeshi, Honda +2 more
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