Results 211 to 220 of about 4,980,683 (248)

TSH signaling and cell survival in 3T3-L1 preadipocytes

American Journal of Physiology-Cell Physiology, 2002
Thyroid-stimulating hormone (TSH) action in adipose tissue remains largely unknown. Our previous work indicates that human preadipocytes express functional TSH receptor (TSHR) protein, demonstrated by TSH activation of p70 S6 kinase (p70 S6K). We have now studied murine 3T3-L1 preadipocytes to further characterize TSH signaling and cellular action ...
Andrea, Bell, Annemarie, Gagnon, Patti, Dods, Denise, Papineau, Mario, Tiberi, Alexander, Sorisky   +5 more
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Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells

Bioorganic & Medicinal Chemistry, 2011
To search for a new class of antidiabetic compounds, effects of 44 flavonoids on the adipogenesis of 3T3-L1 cells were examined. Among them, 3,4',7-trimethylkaempferol, tetramethylkaempferol, and pentamethylquercetin concentration-dependently enhanced the accumulation of triglyceride, a marker of adipogenesis.
Hisashi, Matsuda, Yuichiro, Kogami, Seikou, Nakamura, Tomomi, Sugiyama, Tsubasa, Ueno, Masayuki, Yoshikawa   +5 more
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Estrogens induce visfatin expression in 3T3-L1 cells

Peptides, 2010
Visfatin is a 56 kDa protein that is overexpressed in pregnant women. Like insulin, 2 nM visfatin induced GLUT 4 translocation from the cytosolic fraction to the membrane in 3T3-L1 cells. We have previously reported that visfatin induces glucose uptake into 3T3-L1 cells. These two actions define visfatin as an insulinomimetic.
Jingyu, Zhou, Edward R, Seidel
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ATF3 inhibits adipocyte differentiation of 3T3-L1 cells

Biochemical and Biophysical Research Communications, 2012
ATF3 is a stress-adaptive gene that regulates proliferation or apoptosis under stress conditions. However, the role of ATF3 is unknown in adipocyte cells. Therefore, in this study, we investigated the functional role of ATF3 in adipocytes. Both lentivirus-mediated overexpression of ATF3 and stably-overexpressed ATF3 inhibited adipocyte differentiation ...
Min Kyung, Jang, Cho Hee, Kim, Je Kyung, Seong, Myeong Ho, Jung   +3 more
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Biotin transport into fully differentiated 3T3-L1 cells

Biochemical and Biophysical Research Communications, 1982
Summary The fully differentiated 3T3-L1 cell, like an adipocyte, contains high levels of the biotin-dependent enzymes pyruvate carboxylase and acetyl CoA carboxylase. We have shown that biotin transport into these cells demonstrates many of the characteristics of a carrier mediated mechanism.
N D, Cohen, M, Thomas
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Raloxifene promotes adipocyte differentiation of 3T3-L1 cells

European Journal of Pharmacology, 2006
To explore the possibility that raloxifene might influence an adipocyte differentiation and lipogenesis, we studied the effects of raloxifene on the expression of adiponectin and other peroxisome proliferator-activated receptor gamma targeting genes using the 3T3-L1 adipocytes. With standard adipogenic inducers, we added raloxifene at various doses for
Yuko, Murase, Junji, Kobayashi, Atsushi, Nohara, Akimichi, Asano, Naoto, Yamaaki, Kaoru, Suzuki, Hiroshi, Sato, Hiroshi, Mabuchi   +7 more
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Functional ion channels and cell proliferation in 3T3‐L1 preadipocytes

Journal of Cellular Physiology, 2012
AbstractMouse 3T3‐L1 preadipocytes are widely used for metabolic study of obesity; however, their cellular physiology is not fully understood. The present study investigates functional ion channels and their role in the regulation of cell proliferation using whole‐cell patch voltage‐clamp, RT‐PCR, Western blot, and cell proliferation assay in ...
Li, GR, Zhang, XH, Jin, MW, Sun, HY, Zhang, YY   +4 more
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Effects of persimmon extract in 3T3-L1 cells

Free Radical Biology and Medicine, 2017
There is growing evidence that natural products are important in the relationship between nutrients and healthin humans. Currently, one of the biggest problems in the food industries is the waste management that is generated in food production.
Sara Gea Botella, Teresa Castaño Martínez, David Mula Muñoz, María Herranz López, Vincente Micol, Manuel Valero Roche, Nuria Martí Bruña, Domingo Saura López   +7 more
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WEHI-3 cells inhibit adipocyte differentiation in 3T3-L1 cells

Biochemical and Biophysical Research Communications, 2015
By investigating the anti-adipogenic effects of WEHI-3 cells - a murine acute myelomonocytic leukemia cell line - we sought to improve the efficiency of hematopoietic stem cell transplantation (HSCT). Analysis of Oil Red O staining and the expression of adipogenic genes, including PPARγ, C/EBPα, FAS and LPL, indicated that WEHI-3 cells significantly ...
Jing, Lai, Gexiu, Liu, Guoyao, Yan, Dongmei, He, Ying, Zhou, Shengting, Chen   +5 more
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Modulation of intracellular glutathione affects adipogenesis in 3T3‐L1 cells

Journal of Cellular Physiology, 2011
AbstractImpairment of redox homeostasis has been extensively associated with obesity, as a consequence of the chronic inflammatory state present in overweight subjects. Deregulation of glutathione (GSH), the most important non‐enzymatic intracellular anti‐oxidant, induces insulin resistance in mature adipocytes, but data are lacking about its effects ...
Vigilanza, P, AQUILANO, KATIA, Baldelli, S, ROTILIO, GIUSEPPE, CIRIOLO, MARIA ROSA   +4 more
openaire   +3 more sources