Results 11 to 20 of about 477 (84)

4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters [PDF]

Frontiers in Pharmacology, 2020
Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol.
Tuire Salonurmi, Tuire Salonurmi, Heba Nabil, Heba Nabil, Heba Nabil, Justiina Ronkainen, Justiina Ronkainen, Tuulia Hyötyläinen, Heidi Hautajärvi, Markku J. Savolainen, Markku J. Savolainen, Markku J. Savolainen, Ari Tolonen, Matej Orešič, Päivi Känsäkoski, Jaana Rysä, Jukka Hakkola, Jukka Hakkola, Jukka Hakkola, Janne Hukkanen, Janne Hukkanen, Janne Hukkanen   +21 more
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Liver X Receptor Agonist 4β‐Hydroxycholesterol as a Prognostic Factor in Coronary Artery Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Regardless of progress in treatment of coronary artery disease (CAD), there is still a significant residual risk of death in patients with CAD, highlighting the need for additional risk stratification markers.
Roosa Rahunen, Mikko Tulppo, Valtteri Rinne, Samuli Lepojärvi, Juha S. Perkiömäki, Heikki V. Huikuri, Olavi Ukkola, Juhani Junttila, Janne Hukkanen   +8 more
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Significant increase in plasma 4β-hydroxycholesterol concentration in patients after kidney transplantation [PDF]

Journal of Lipid Research, 2013
Several previous studies have shown that renal failure decreases not only renal elimination but also metabolic clearance of drugs, particularly those metabolized by CYP3A.
Yosuke Suzuki, Hiroki Itoh, Fuminori Sato, Kanako Kawasaki, Yukie Sato, Takashi Fujioka, Yuhki Sato, Keiko Ohno, Hiromitsu Mimata, Satoshi Kishino   +9 more
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Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia [PDF]

Annals of Medicine
Background Liver X receptors (LXRs) are expressed in placenta and may be associated with pre-eclampsia (PE). Oxysterols act as agonists for LXRs. We recently proposed a new blood pressure-regulating circuit with oxysterol 4β-hydroxycholesterol (4βHC ...
Lassi Kaartinen, Tiina Jääskeläinen, Eeva Sliz, Gamze Yazgeldi Gunaydin, Satu Wedenoja, Shintaro Katayama, Eero Kajantie, Valtteri Rinne, Seppo Heinonen, Juha Kere, Heta Merikallio, Eeva Sliz, Hannele Laivuori, Janne Hukkanen   +13 more
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No impact of vitamin D on the CYP3A biomarker 4β-hydroxycholesterol in patients with abnormal glucose regulation. [PDF]

PLoS ONE, 2015
PURPOSE:To investigate the effect of vitamin D3 on hepatic Cytochrome P450 enzyme (CYP) 3A4 in patients with abnormal glucose regulation using the endogenous marker 4β-hydroxycholesterol (4β-OHC):cholesterol ratio.
Buster Mannheimer, Henrik Wagner, Claes-Göran Östenson, Ulf Diczfalusy   +3 more
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Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity [PDF]

Frontiers in Pharmacology
IntroductionIncreased CYP3A-mediated drug clearance during pregnancy can lead to subtherapeutic dosing of CYP3A substrates. Pregnancy-related hormones (PRHs) increase CYP3A4 expression and activity in cultured human hepatocytes.
Muluneh M. Fashe, Jonghwa Lee, Joseph T. Grieco, John K. Fallon, Ian R. Mulrenin, Megan N. Gower, Klarissa D. Jackson, Kim A. Boggess, Craig R. Lee   +8 more
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PHENOTYPING CYP3A4/5 USING AN ENDOGENOUS BIOMARKER IN CHILDREN WITH DOWN SYNDROME [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2020
Background: Down syndrome (DS); a common chromosomal abnormality in humans can affect multiple organ systems. DS individuals usually use a wide range of medications.
Lateef Khan, Alaa Khedr, Fuad Almaweri, Jumana AlAama, Ahmed Ali, Zoheir Damanhouri   +5 more
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Sensitive UHPLC-MS/MS quantification method for 4β- and 4α-hydroxycholesterol in plasma for accurate CYP3A phenotyping

Journal of Lipid Research, 2022
4β-Hydroxycholesterol (4β-OHC) is formed by Cytochrome P450 (CYP)3A and has drawn attention as an endogenous phenotyping probe for CYP3A activity. However, 4β-OHC is also increased by cholesterol autooxidation occurring in vitro due to dysregulated ...
Yosuke Suzuki, Ayako Oda, Jun Negami, Daiki Toyama, Ryota Tanaka, Hiroyuki Ono, Tadasuke Ando, Toshitaka Shin, Hiromitsu Mimata, Hiroki Itoh, Keiko Ohno   +10 more
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On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Journal of Lipid Research, 2002
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney, Karl Bodin, Ulf Diczfalusy, Ingemar Björkhem   +3 more
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Risk assessment of drug–drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach

Clinical and Translational Science, 2022
Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of TGF‐βRII (a TGF‐β “trap”) fused to a human IgG1 mAb blocking PD‐L1, is being evaluated for efficacy and safety in solid tumor indications as monotherapy
Yulia Vugmeyster, George Locke, Christoph Helwig, P. Alexander Rolfe, Jennifer Q. Dong, Karthik Venkatakrishnan   +5 more
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