Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. [PDF]
Br J Clin Pharmacol, 2017 The CYP3A metric 4β-hydroxycholesterol (4βOHC) has been shown to correlate with tacrolimus steady-state apparent oral clearance (CL/F). Recently, pretransplant 4βOHC was shown not to predict tacrolimus CL/F after transplantation in a cohort of renal ...
Vanhove T +4 more
europepmc +2 more sources
Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol
, 2023 Oxysterols are oxidized derivatives of cholesterol that are formed by enzymatic processes or through the action of reactive oxygen species. Several of these bioactive lipids have been shown to be affected and/or play a role in inflammatory processes.
Roumain, Martin +9 more
core +1 more source
The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. [PDF]
Br J Clin Pharmacol, 2017 Aims: Tacrolimus is a cornerstone in modern immunosuppressive therapy after kidney transplantation. Tacrolimus dosing is challenged by considerable pharmacokinetic variability, both between patients and over time after transplantation, partly due to ...
Størset E +5 more
europepmc +2 more sources
Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS [PDF]
, 2020 Cholesterol oxidation product 4β‑hydroxycholesterol (4β‑OHC) may possibly be used as an endogenous biomarker of CYP3A enzyme activity and as CYP3A4 is involved in the metabolism of approximately 50% of the drugs in clinical use, the monitoring of CYP3A ...
Turpeinen, Miia +4 more
core +1 more source
Journal of Lipid Research, 2002 Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney +3 more
doaj +1 more source
Clinical and Translational Science, 2022 Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of TGF‐βRII (a TGF‐β “trap”) fused to a human IgG1 mAb blocking PD‐L1, is being evaluated for efficacy and safety in solid tumor indications as monotherapy
Yulia Vugmeyster +5 more
doaj +1 more source
4β-hydroxycholesterol correlates with dose but not steady-state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation? [PDF]
Br J Clin Pharmacol, 2016 There is extensive interindividual variability in drug response and tolerability. One of the major reasons for this is differences in drug metabolism, which may reflect pharmacogenetic variability and/or environmental factors, such as age and drug-drug ...
Gjestad C +3 more
europepmc +2 more sources
Cholesterol 25-hydroxylation activity of CYP3A
Journal of Lipid Research, 2011 To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda +8 more
doaj +1 more source
Clinical and Translational Science, 2022 PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε under clinical development to treat disruption of circadian rhythm in Alzheimer's and Parkinson's diseases.
Jian Lin +6 more
doaj +1 more source
A Japanese prospective multicenter study of urinary oxysterols in biliary atresia
Scientific Reports, 2021 Diagnosis of biliary atresia (BA) can involve uncertainties. In the present prospective multicenter study, we considered whether urinary oxysterols represent a useful marker for diagnosis of BA in Japanese children.
Ken-ichiro Konishi +25 more
doaj +1 more source