Results 31 to 40 of about 775 (125)
Effect of obesity and metabolic syndrome on plasma oxysterols and fatty acids in human [PDF]
, 2015 BACKGROUND: Obesity and the related entity metabolic syndrome are characterized by altered lipid metabolism and associated with increased morbidity risk for cardiovascular disease and cancer.
H., Guillou +7 more
core +2 more sources
Clinical and Translational Science, 2022 PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε under clinical development to treat disruption of circadian rhythm in Alzheimer's and Parkinson's diseases.
Jian Lin +6 more
doaj +1 more source
The Effects of an Obesogenic Diet on Liver Oxysterol Metabolism in C57BL/6J Mice [PDF]
, 2011 Oxysterols are key regulators of lipid metabolism and play a role in the etiology of atherosclerosis; however, our current understanding of tissue levels of oxysterols during different disease states such as obesity is limited.
Hoogeveen, Ron C. +6 more
core +2 more sources
Oxysterols and retinal degeneration [PDF]
, 2021 Retinal degeneration, characterised by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate cholesterol ...
Alhasani, Reem Hasaballah +6 more
core +2 more sources
A Japanese prospective multicenter study of urinary oxysterols in biliary atresia
Scientific Reports, 2021 Diagnosis of biliary atresia (BA) can involve uncertainties. In the present prospective multicenter study, we considered whether urinary oxysterols represent a useful marker for diagnosis of BA in Japanese children.
Ken-ichiro Konishi +25 more
doaj +1 more source
Oxysterols and Their Cellular Effectors [PDF]
, 2012 Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain
Béaslas, Olivier +2 more
core +3 more sources
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MSs⃞
Journal of Lipid Research, 2009 We describe a highly sensitive and specific method for the quantification of key regulatory oxysterols in biological samples. This method is based upon a stable isotope dilution technique by liquid chromatography-tandem mass spectrometry (LC-MS/MS ...
Akira Honda +8 more
doaj +1 more source
Clinical studies of CYP3A4 and P-glycoprotein [PDF]
, 2016 In the field of pharmacokinetics, cytochrome P450 enzymes have been extensively studied. The CYP450 enzyme with the most drug substrates is CYP3A4, but despite its significance, administration of a specific substrate to subjects is required to determine ...
Sparve, Erik
core +1 more source
Evaluating the effect of pregnancy on hepatic CYP3A4 expression and metabolism in humanized mice and human volunteers [PDF]
, 2023 Pregnancy is associated with various physiologic changes that affect drug disposition. Studies have shown that CYP3A4 metabolism and clearance of CYP3A4 metabolized drug substrates increase during pregnancy in humans.
Laboy Collazo, Valeria
core +2 more sources
Frontiers in Pharmacology, 2022 Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo.
Miao Zhang +16 more
doaj +1 more source