Results 81 to 90 of about 4,503 (108)

Modeling and simulation of the endogenous CYP3A induction marker 4β-hydroxycholesterol during enasidenib treatment

Clinical Pharmacology: Advances and Applications, 2019
Yan Li,1 Jamie N Connarn,1 Jian Chen,2 Zeen Tong,2 Maria Palmisano,1 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ, USA; 2Non-Clinical Development, Celgene Corporation, Summit, NJ, USA Background ...
Li Y, Connarn JN, Chen J, Tong Z, Palmisano M, Zhou S   +5 more
doaj  

Gene Polymorphisms of NLRP3 Associated With Plasma Levels of 4β-Hydroxycholesterol, an Endogenous Marker of CYP3A Activity, in Patients With Asthma [PDF]

Inflammation decreases the activity of cytochrome P450 3A (CYP3A). Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) is responsible for regulating the inflammatory response, and its genetic ...
Hirai, Keita, Kimura, Tomoki, Suzuki, Yuya, Itoh, Kunihiro, Shirai, Toshihiro, Shimoshikiryo, Takayuki   +5 more
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Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time. [PDF]

Eur J Clin Pharmacol, 2022
Tung NP, Ma JD.
europepmc   +1 more source

Bobbing of 27-hydroxycholesterol.

, 2018
<p>Movie showing the bobbing of 27-hydroxycholesterol.</p ...
Kulig, Waldemar, Kulig, Waldemar (5268277)   +1 more
core   +1 more source

Response to: "Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time". [PDF]

Eur J Clin Pharmacol, 2022
Kvitne KE, Hole K, Molden E, Robertsen I.   +3 more
europepmc   +1 more source

Effect of 25-hydroxycholesterol, 26-hydroxycholesterol and its analogue, 26-aminocholesterol, on protein content, protein synthesis and LDH leakage in mouse epidermal cells

, 1995
The cytotoxicity of 25-hydroxycholesterol, 26-hydroxycholesterol and its analogue, 26-aminocholesterol was investigated in murine epidermal cell line, HEL-30.
R. Paoletti, C.L. Galli, F. Ghilardi, M. Guizzetti, M. Marinovich   +4 more
core   +1 more source

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

, 2000
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance.
Siden, A, Bjorkhem, I, Lutjohann, D, Bretillon, L, Wahlund, L O, Minthon, Lennart, Diczfalusy, U, Crisby, M, Hillert, J, Groth, C G   +9 more
core   +1 more source

Betydning av CYP3A4/5- og POR-genotype for individuell variasjon i nivå av 4β-hydroksykolesterol [PDF]

, 2015
Problemstilling: Enzymer tilhørende cytokrom P450 3A (CYP3A)-subfamilen representerer de viktigste i metabolisme av legemidler. Det er stor individuell variasjon i CYP3A-fenotype, og 4β-hydroksykolesterol (4β-OH-K) er en aktuell biomarkør for denne ...
Heitmann, Kristine
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Unusual oxidative pattern in thermo-oxidation of dry films of cholesterol [Patrón oxidativo inusual en la termo-oxidación de películas secas de colesterol]

, 2011
Formation of cholesterol oxidation products (COPs) during dry heating of cholesterol films at 150°C for 48 h was studied. A method based on aminopropyl solid-phase extraction (SPE), followed by GC-MS analysis was employed for the identification and ...
l. G. Medina Meza, H. S. García Galindo, I. Soto Rodriguez, LERCKER, GIOVANNI, RODRIGUEZ ESTRADA, MARIA TERESA   +4 more
core   +1 more source

The Influence of Dietary Cholesterol on 26-Hydroxycholesterol and the Effect of 26-Hydroxycholesterol on the Intracellular Free Calcium Level

, 1987
Oxidized derivatives of cholesterol, such as 26-hydroxycholesterol are an enzymatic oxidation product of cholesterol, which have been studied in vivo and in vitro systems.
Kou, I-Ling
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