Results 51 to 60 of about 775 (125)

Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy. [PDF]

, 2018
BackgroundEquine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet.
Bordbari, Matthew H, Burns, Erin N, Estell, Krista E, Finno, Carrie J, Katzman, Scott, Miller, Andrew D, Puschner, Birgit, Tran, Cecilia K, Winfield, Laramie, Xu, Libin   +9 more
core  

A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker

Pharmacological Research
Perturbed cholesterol metabolism may play an important role in the development of dementia and its preclinical stage, mild cognitive impairment (MCI). Oxysterols, the metabolites generated during cholesterol oxidation, also appear to be risk factors for ...
Yu An, Yuandi Xi, Tao Wang, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Kexin Yang, Chengyan Qi, Rong Xiao   +9 more
doaj   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, EarlyView.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Early or deferred initiation of efavirenz during rifampicin‐based TB therapy has no significant effect on CYP3A induction in TB‐HIV infected patients [PDF]

, 2020
Background and Purpose: In TB‐HIV co‐infection, prompt initiation of TB therapy is recommended but anti‐retroviral treatment (ART) is often delayed due to potential drug–drug interactions between rifampicin and efavirenz.
Aklillu, E, Amogne, W, Burhenne, J, Diczfalusy, U, Habtewold, A, Makonnen, E, Yimer, G, Zumla, A   +7 more
core  

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

Redox Biology, 2016
Alzheimer's disease (AD) is a gradually debilitating disease that leads to dementia. The molecular mechanisms underlying AD are still not clear, and at present no reliable biomarkers are available for the early diagnosis.
Gabriella Testa, Erica Staurenghi, Chiara Zerbinati, Simona Gargiulo, Luigi Iuliano, Giorgio Giaccone, Fausto Fantò, Giuseppe Poli, Gabriella Leonarduzzi, Paola Gamba   +9 more
doaj   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Elevated acute phase proteins affect pharmacokinetics in COVID-19 trials: Lessons from the CounterCOVID - imatinib study. [PDF]

, 2021
This study aimed to determine whether published pharmacokinetic (PK) models can adequately predict the PK profile of imatinib in a new indication, such as coronavirus disease 2019 (COVID-19).
Aman, J., Bartelink, I.H., Bet, P.M., Decosterd, L.A., Duijvelaar, E., Evelo, A., Grob, B., Guidi, M., Hamer, H., Honeywell, R., Jan Bogaard, H., Snape, S.D., Swart, E.L., Tielbeek, IPE, Widmer, N.   +14 more
core   +3 more sources

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Translational aspects of drug metabolism in inflammation and disease [PDF]

, 2022
Lægemidler udgør fundamentet i behandlingen af de fleste medicinske sygdomme. Enudfordring ved behandling med lægemidler er, at der kan være stor forskel i effekt ogbivirkninger blandt patienter.
Dunvald, Ann-Cathrine Dalgård
core   +1 more source