Results 121 to 130 of about 9,315,415 (239)

Crystal and molecular structure of 2,6-dimethyl-3,5-di[N-methyl]carbamoyl-4-[3,4-methoxy]phenyl-l,4-dihydropyridine hemihydrate and 2,6-dimethyl-3,5-di[N-methyl]carbamoyl-4-[furan]1,4-dihydropyridine

open access: yes, 1999
The crystal structures of two dihydropyridines were solved by direct methods and refined by full-matrix least-squares procedure. 2,6-Dimethyl-3,5-di[N-methyl]-carbamoyl-4-[3,4-methoxy]phenyl-1,4-dihydropyridine hemihydrate, C38H50N6O9 (compound 1 ...

core   +1 more source

Aerobic exercise partially improves the skeletal muscle phenotype in a model of heart failure with preserved ejection fraction in male mice

open access: yesPhysiological Reports, Volume 14, Issue 11, June 2026.
Abstract Heart failure with preserved ejection fraction (HFpEF) is associated with skeletal muscle dysfunction that contributes to exercise intolerance and disease progression. Altered Ca2+ homeostasis and increased oxidative stress have been proposed as mechanisms underlying muscle weakness in HFpEF; however, the effects of aerobic exercise on ...
Cielo Martínez Martínez   +8 more
wiley   +1 more source

Diethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and Ethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

open access: yes, 2012
Diethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylate and ethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained simultaneously by the Biginelli ...
Mirella Rambaldi   +9 more
core   +1 more source

Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman   +2 more
wiley   +1 more source

Application of a new high performance liquid chromatography method to the pharmacokinetics of dibudipine in rats [PDF]

open access: yes
Purpose: To develop a HPLC method for assay of dibudipine in biological fluids and to study its pharmacokinetics in the rat. Methods. HPLC: 2 μl (20 μg/ml) mebudipine as internal standard, 0.2 ml NaOH 1 M and 2 ml ethyl acetate were added to 0.2 ml of ...
محمودیان, مسعود   +3 more
core  

A New Synthetic Approach to the Preparation of Indolo[3,2‐c]quinolines From Sulfonylalkyl Indoles

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
Functionalized indolo[3,2‐c]quinolines can be efficiently prepared from sulfonylalkyl indoles by a cascade process involving reduction, vinylogous aza‐Michael and aromatization reactions triggered by zinc powder in acetic acid at reflux. The reductive cyclization of sulfonylalkyl indoles obtained from 2‐(o‐nitroaryl)indoles, provides an efficient ...
Francesca Cecchini   +3 more
wiley   +1 more source

Dimethyl 4-(3-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

open access: yes, 2010
The 1,4-dihydropyridine ring in the title compound, C17H19NO5, has a flattened-boat conformation, and the benzene ring is almost orthogonal to it [dihedral angle = 82.98 (12)°]. The hydroxy group is disordered over two positions in a 0.
V. Vijayakumar   +9 more
core   +1 more source

Convenient synthesis of 4H-chromenyl-tetrahydro-2H-pyrancarboxylates and cleavage of chromone and pyran rings leading to 5-(2-hydroxybenzoyl)-2-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylates

open access: yes, 2016
4H-Chromenyl-tetrahydro-2H-pyrancarboxylates 3a–k have been conveniently prepared by the reaction of 3-formylchromones 1a–k and ethyl 4,4,4-trifluoro-3-oxobutanoate 2a with good yields. Thus obtained 4H-chromenyl-tetrahydro-2H-pyrancarboxylates 3a–k were
Bhimapaka China Raju (736492)   +3 more
core   +1 more source

Synthesis of propargyl substituent containing 4 (4-alkylpyridiyl) - 1,4 - dihydropyridine derivates and studies of properties

open access: yes, 2014
Propargilaizvietotāju saturošu 4-(N-alkilpiridil)-1,4-dihidropiridīna atvasinājumu iegūšana un īpašību pētījumi. Jēkabsone M. zinātniskais vadītājs doktorants, M.Sc. Ruciņš M.
Jēkabsone, Madara
core  

Inhibition of Alzheimer's BACE-1 by 2,6-dialkyl-4-chromon-3-yl-1,4-dihydropyridine-3,5-dicarboxylates

open access: yes, 2015
Alzheimer’s disease is the most common cause of dementia in the elderly, and no disease-modifying therapy is yet available for this devastating pathology.
Srivastava, S.   +7 more
core   +1 more source

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