Results 101 to 110 of about 9,315,415 (239)
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Molecules, 2018 As a follow-up to our previous studies on differently substituted 1,4-dihydropyridines endowed with a peculiar cardiac selectivity, in this paper, a small series of hybrid compounds bearing the pharmacophore fragment of lidoflazine in position 2 or 3 on ...
Alessandra Bisi +5 more
doaj +1 more source
Onset time of Ca antagonistic action of CD-349 in comparison with other dihydropyridine compounds
, 2007 AN0016561X-20071226-77We examined the relationship between the tissue distribution and the time of onset of the calcium antagonistic action of CD-349 in comparison with nicardipine and nitrendipine.
WATAJIMA, Hiroshi +12 more
core
Diisopropyl 1-(4-methoxyphenyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
, 2011 In the title compound, C28H32N2O7, the 1,4-dihydropyridine ring adopts a flattened boat conformation. The two benzene rings are approximately perpendicular to the dihydropyridine ring, forming dihedral angles of 84.29 (9) and 82.96 (9)
Vivek K. Gupta +4 more
core +1 more source
International Journal of Biomedical Research, 2012 Some new Mannich Bases of 1, 4 Dihydropyridine derivatives were synthesised by reaction of 1, 4 Dihydropyridine derivatives formaldehyde (HCHO) & secondary amines (e.g. morpholine, 1-methyl piperazine) in 1:1 ratio under acidic condition in presence of trace HCl.
Pravin Jadhav +2 more
openaire +2 more sources
A Combined MS/MS and IMS Study Into the Fragmentation Pathway of Nifedipine
Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.ABSTRACT Collision‐induced dissociation (CID) of small molecules, typically with a molecular mass below 1500 Da, is widely applied for the structural identification of drug metabolites, synthetic by‐products and unknown compounds. Nonetheless, the interpretation of MS/MS spectra derived from protonated or sodiated molecules mainly relies on the ...
Peiliang Han +2 more
wiley +1 more source
Drug Design, Development and Therapy, 2022 Idhayadhulla Akbar,1 Surendrakumar Radhakrishnan,1 Karpakavalli Meenakshisundaram,2 Aseer Manilal,3 Ashraf Atef Hatamleh,4 Bassam Khalid Alnafisi,4 Anis Ahamed,4 Ravindran Balasubramani5 1Research Department of Chemistry, Nehru Memorial College ...
Akbar I +7 more
doaj
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Hydronium 4-oxo-1,4-dihydropyridine-3-sulfonate dihydrate
Acta Crystallographica Section E, 2009 2-Hydroxypyridine when treated with concentrated sulfuric acid is sulfonated at the 3-position to yield the title hydrated salt, H3O+·C5H4NO3S−·2H2O.
Zhi-Biao Zhu, Shan Gao, Seik Weng Ng
doaj +1 more source
Synthesis of 1, 4-Dihydropyridine Derivatives using FeCl3 as Catalyst under Solvent-free Condition
Oriental Journal Of Chemistry, 2013 Chemistry of dihydropyridines in 1882 with Ar thur Hansh reports the β-keto ester, aldehydes and ammonia can be combined to form 1, 4-dihydropyridine was developed. Because of the many benefits of 1, 4-dihydropridine is presented and now as vital medicines to treat angina, high blood pressure and allergies have been introduced.
ABDORRAHMAN KEYHANI, FARHAD HATAMJAFARI
openaire +1 more source