Results 101 to 110 of about 19,839 (264)

QSAR Modeling of COX-2 Inhibitory Activity of Thiazinan, Benzthiazinan and Benzdiazinan Derivatives [PDF]

open access: yes, 2018
COX-2 inhibitory activities of some thiazinan, benzdiazinan and benzthiazinan derivatives were modeled by quantitative structure–activity relationship (QSAR) with stepwise-multiple linear regression (SW-MLR) method.
Akbarpour Avini, Sara   +3 more
core   +2 more sources

A Case Report of Acute Renal Failure due to Amlodipine Overdose and Alcohol Consumption

open access: yesClinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Amlodipine intoxication is clinically common yet life‐threatening, usually resulting in severe cardiovascular collapse and end‐organ hypoperfusion. Here, we report a case of a 46‐year‐old male with amlodipine (420 mg) and ethanol intoxication who unexpectedly presented without severe hypotension or shock.
Yi Xi
wiley   +1 more source

Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment

open access: yesMolecules, 2018
As a follow-up to our previous studies on differently substituted 1,4-dihydropyridines endowed with a peculiar cardiac selectivity, in this paper, a small series of hybrid compounds bearing the pharmacophore fragment of lidoflazine in position 2 or 3 on ...
Alessandra Bisi   +5 more
doaj   +1 more source

Investigating the Anti-Cancer Properties of Novel Hybrid 1,4-Dihydropyridine Derivatives in U-87MG Glioblastoma Cell [PDF]

open access: yes, 2019
Glioblastoma is the most devastating of brain cancers with a very high death rate and a low survival rate of less than 15 months after diagnosis. Glioblastoma is a cancer of astrocytes which are the majority of the brain glial cells that support neurons ...
Hunyenyiwa, Tendai
core   +1 more source

Organophotoredox/Cobalt‐Catalyzed Retro‐Hydroformylation of Aldehydes

open access: yesChemistryEurope, Volume 4, Issue 4, April 2026.
A new photoredox/cobalt retro‐hydroformylation is developed. This one‐pot two‐step process involves the in situ formation of the corresponding 1,4‐dihydropyridine as key intermediate. Under mild reaction conditions, alkenes are efficiently produced from a wide range of aliphatic α‐monosubstituted aldehydes, with high functional‐group tolerance.
Augustin Nouaille   +3 more
wiley   +1 more source

Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies

open access: yesDrug Design, Development and Therapy, 2022
Idhayadhulla Akbar,1 Surendrakumar Radhakrishnan,1 Karpakavalli Meenakshisundaram,2 Aseer Manilal,3 Ashraf Atef Hatamleh,4 Bassam Khalid Alnafisi,4 Anis Ahamed,4 Ravindran Balasubramani5 1Research Department of Chemistry, Nehru Memorial College ...
Akbar I   +7 more
doaj  

4-(3,5-Dibromo-4-hydroxyphenyl)-3-butoxycarbonyl-5-ethoxycarbonyl-2-methyl-6-phenyl-1,4-dihydropyridine

open access: yesMolbank, 2011
One-pot two-step Hantzsch synthesis of 4-(3,5-dibromo-4-hydroxyphenyl)-3- butoxycarbonyl-5-ethoxycarbonyl-2-methyl-6-phenyl-1,4-dihydropyridine under solvent- and catalyst-free conditions promoted with microwave irradiation is presented.
Zhen Wang, Qingjian Liu
doaj   +1 more source

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