Results 91 to 100 of about 90,592,261 (228)

4-[(2E)-2-(4-Chlorobenzylidene)hydrazinylidene]-1-methyl-1,4-dihydropyridine monohydrate

Acta Crystallographica Section E, 2010
In the title compound, C13H12ClN3·H2O, the organic molecule is almost planar, with a dihedral angle of 3.22 (10)° between the benzene and pyridine rings. The crystal structure is stabilized by O—H...N and C—
Abdullah Aydın, Mehmet Akkurt, Vildan Alptüzün, Orhan Büyükgüngör, Ulrike Holzgrabe, Krzysztof Radacki   +5 more
doaj   +1 more source

Gold‐Catalyzed Cyclization of Indole‐Tethered Alkynes Enabling Synthesis of Exocyclic Alkenyl Tetrahydrocarbazoles

European Journal of Organic Chemistry, Volume 29, Issue 41, 3 November 2026.
An efficient gold‐catalyzed intramolecular cyclization of indole‐tethered alkynes using AgNTf2 as an additive has been developed, which provides bioactive exocyclic alkenyl tetrahydrocarbazoles with up to 85% yield. Control experiments and DFT studies indicate that the reaction proceeds via a 6‐exo‐dig cyclization pathway, with gold acetylide complexes
Haibo Mei, Jingrui He, Chengting Wang, Jorge Escorihuela, Jianlin Han   +4 more
wiley   +1 more source

Synthesis and evaluation of calcium channel antagonist activity of new 1, 4-dihydropyridines containing phenylamineimidazolyl substitute in guinea-pig ileal smooth muscle

Journal of Research in Medical Sciences, 2004
Background: 1,4-dihydropyridines are a class of drugs which are used in the treatment of some cardiovascular disorders. The prototype, Nifedipine, does not have optimal pharmacokinetic and pharmacodynamic properties.
A Fassihi, H Sadeghi, A Zarghi, A Shafiee   +3 more
doaj  

2,6-Diamino-4-(4-chlorophenyl)-1-methyl-1,4-dihydropyridine-3,5-dicarbonitrile

Acta Crystallographica Section E, 2014
In the title compound, C14H12ClN5, the dihydropyridine ring adopts a shallow boat conformation. The dihedral angle between the plane of this ring and that of the chlorobenzene ring is 69.15 (15)°.
Michael Purushothaman, Kaliyaperumal Thanigaimani, Suhana Arshad, Sekar Silambarasan, Ibrahim Abdul Razak, Kather Mohideen Sithick Ali   +5 more
doaj   +1 more source

Acid‐Free, Room‐Temperature Carbamoylations of Heteroaromatics With N‐Substituted Formamides via TBADT Catalysis and Hydrogen Bonding

Chemistry–Methods, Volume 6, Issue 11, November 2026.
TBAB boost the TBADT catalyzed carbamoylations of heteroaromatics with N‐substituted formamides through halogen─hydrogen bonding network. TBADT‐catalyzed carbamoylation under heat‐free neutral conditions has been reported. Unlike conventional reports, the addition of TBAB, which could promote the TBADT catalytic system via bromide─hydrogen bonding ...
Ziheng Yu, Shaojie Liu, Tongtong Liu, Zexuan Wei, Hongmei Li, Tao Lu, Yadong Chen, Yatian Huang, Jie Feng   +8 more
wiley   +1 more source

Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment

Molecules, 2018
As a follow-up to our previous studies on differently substituted 1,4-dihydropyridines endowed with a peculiar cardiac selectivity, in this paper, a small series of hybrid compounds bearing the pharmacophore fragment of lidoflazine in position 2 or 3 on ...
Alessandra Bisi, Matteo Micucci, Silvia Gobbi, Federica Belluti, Roberta Budriesi, Angela Rampa   +5 more
doaj   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Synthesis and structural conformation studies of a potent unsymmetrical 1,4-dihydropyridine

, 2008
2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was characterized spectroscopically and confirmed by X-ray diffraction studies.
Naveen, S., Arun Mishra, Shashidhara Prasad, J., Dinesh Manvar, Anandalwar, S. M., Anamik Shah   +5 more
core   +1 more source

Dysglycaemia and Autonomic Dysfunction: The Diabetes Prevention Program Outcomes Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10743-10752, November 2026.
ABSTRACT Aim Limited data on the link between various measures of glycemia and metabolism and autonomic dysfunction exist. We assessed the association of fasting plasma glucose [FPG], glycated haemoglobin [HbA1C], fasting insulin, and HOMA‐IR and cardiac autonomic function measures separately for men and women in the Diabetes Prevention Program ...
Justin B. Echouffo‐Tcheugui, Xun Liu, Elsayed Z. Soliman, Xavier Pi‐Sunyer, Sherita H. Golden, Sam Dagogo‐Jack, Neil H. White, Matthew Budoff, Uzoma Ibebuogu, Christine Darwin, William C. Knowler, Marinella Temprosa, on behalf of the DPP Research Group   +12 more
wiley   +1 more source

Conformation of 1,4-dihydropyridine - planar or boat-like?

, 1988
The geometry of the 1,4-dihydropyridine molecule was completely optimized employing three different ab initio basis sets (6–31 G*, 4–31 G, STO—3G).
R. Cimiraglia, CIMIRAGLIA, Renzo, H. Hofmann, H.-J. Hofmann   +3 more
core   +1 more source