Results 71 to 80 of about 90,592,261 (228)

High‐resolution pressure myography reveals pressure‐dependent local contractile and geometric dynamics in the renal pelvis and ureter

British Journal of Pharmacology, EarlyView.
Background and Purpose Coordinated peristalsis between the renal pelvis and ureter is critical for effective urine transport. However, intraluminal pressure impact on upper urinary tract (UUT) contractility and pharmacologic responsiveness remains poorly understood due to absence of suitable investigative methods.
Zhugang Chu, Qidi Zhai, Liming Lu, Maik Gollasch, Dmitry Tsvetkov, Rong Dong, S. R. Wayne Chen, Gang Fan, Guangheng Luo, Mario Kassmann   +9 more
wiley   +1 more source

Refining Residual Ischemic Stroke Risk in Anticoagulated Atrial Fibrillation Using Index Outpatient LA Diameter: The CHA2DS2‐VALa Score

Journal of Cardiovascular Electrophysiology, EarlyView.
In anticoagulated atrial fibrillation, residual ischemic stroke risk persists despite guideline‐directed therapy. In this single‐center cohort, an enlarged index outpatient left atrial diameter independently predicted stroke and improved risk stratification when added to CHA2DS2‐VA (CHA2DS2‐VALa), supporting a simple, clinically implementable ...
Sefa Erdi Ömür, Emin Koyun, Gülşen Genç Tapar, Kayıhan Karaman, Metin Karayakali, Ataç Çelik, Uğur Kulu, Yasin Taşkin   +7 more
wiley   +1 more source

CERIC (IV) AMMONIUM NITRATE CATAYSED HUNTZSCH SYNTHESIS ,CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF 1-4 DIHYDROPYRIDINE [PDF]

, 2020
1,4-Dihydropyridine (1,4-DHP) is among the most beneficial scaffolds that have revolutionized pharmaceutical research with unprecedented biological properties.
G, Vanaja
core  

MODULATION OF CALCIUM CHANNELS IN ARTERIAL SMOOTH-MUSCLE CELLS BY DIHYDROPYRIDINE ENANTIOMERS [PDF]

, 1993
The actions of the optical enantiomers of BAY K 8644 and Sandoz 202,791 were studied on barium inward currents recorded using the whole-cell configuration of the patch clamp technique from enzymatically isolated smooth muscle cells from the rabbit ear ...
S Hering, Hughes, AD, Hering, S, T B Bolton, E N Timin, Timin, EN, Bolton, TB, A D Hughes   +7 more
core   +1 more source

Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione

Molecules, 2011
Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4 ...
Fernando Albericio, Nazario Martín, Hortensia Rodríguez, Osnieski Martin, Margarita Suarez   +4 more
doaj   +1 more source

Risk Factors and Management of Gingival Enlargement: A Systematic Review and Meta‐Analysis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Objective To identify risk factors/indicators of gingival enlargement (GE) and to summarise evidence for its management. Methods A systematic review was undertaken following PRISMA guidelines and divided into PECOTS and PICOTS questions, related to risk factors/indicators and treatment studies, respectively.
Luigi Nibali, Emily Ming‐Chieh Lu, Helvis E. S. Paz, Jing Kang, Nagihan Bostanci, Georgios N. Belibasakis   +5 more
wiley   +1 more source

Parasympathetic dysfunction assessed by deep‐breathing CVR‐R is associated with early discontinuation of oral semaglutide in type 2 diabetes: A multicenter retrospective study

Journal of Diabetes Investigation, EarlyView.
Lower CVR‐R during deep breathing (CVR‐R_DB), a marker of parasympathetic function, was associated with early discontinuation of oral semaglutide due to nausea and/or vomiting in patients with type 2 diabetes. CVR‐R_DB may support risk stratification at treatment initiation.
Kazuma Ogiso, Takahisa Deguchi, Shigeru Kawade, Aiko Arimura, Yoshihiko Nishio, Katsutaro Morino   +5 more
wiley   +1 more source

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle [PDF]

, 2006
The deficiency of dystrophin, a critical membrane stabilizing protein, in the mdx mouse causes an elevation in intracellular calcium in myocytes. One mechanism that could elicit increases in intracellular calcium is enhanced influx via the L-type calcium
Lu, Sai, Watson, M, Woolf, Peter James, Cornford-Nairn, R, Holroyd, SM, Hoey, Andrew, Woolf, PJ, Cornford-Nairn, Renee, Hoey, Andrew J., Xiao, Xiao-Hui, Woolf, Peter J., Xiao, XH, Holroyd, Sean M., Watson, Michael, Cornford-Nairn, Renee A., Brown, Lindsay, Holroyd, Sean   +16 more
core   +1 more source

Simultaneous acquisition of maternal and dual‐fetal electrocardiography with maternal haemodynamic monitoring in anaesthetized pregnant rats

Experimental Physiology, EarlyView.
Abstract Experimental approaches that acquire maternal haemodynamics together with direct cardiac signals from more than one fetus remain limited. We developed a standardized in vivo method for simultaneous acquisition of maternal ECG, maternal arterial blood pressure and ECGs from two fetuses in anaesthetized late‐gestation Sprague–Dawley rats.
Sarah Pribil Pardun, Spencer Duff, Payton Ward, Auspy Li, Lie Gao   +4 more
wiley   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source