Results 51 to 60 of about 90,592,261 (228)

1, 4-Dihydropyridine Derivatives : Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress1, 4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Oxidative medicine and cellular longevity, 2016
Many 1, 4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA).
Žarković, Neven, Gall Trošelj, Koraljka   +1 more
openaire   +2 more sources

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Synthesis and crystal structures of four new dihydropyridine derivatives

, 2013
Four new Hantzsch 1,4-dihydropyridine derivatives, dimethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3, 5-dicarboxylate, (I), dimethyl 4-(4-bromophenyl)-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarboxylate, (II), dimethyl 4-(3-bromo ...
Butcher, Ray J., Pek, A. E., Narayana, B., Jasinski, J. P., Samshuddin, S., Guild, Curtis J., Yathirajan, H. S.   +6 more
core   +1 more source

Hantzsch Synthesis of 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-methoxyphenyl)-1,4-dihydropyridine; a Novel Cyclisation Leading to an Unusual Formation of 1-Amino-2-methoxycarbonyl-3,5-bis(o-methoxyphenyl)-4-oxa-cyclohexan-1-ene

Molecules, 2007
Hantzsch condensation of two equivalents of methyl-3-aminocrotonate with (m-and p)-methoxybenzaldehyde afforded the expected products 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(m-methoxyphenyl)-1,4-dihydropyridine and 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(p ...
Vladimir Vinković, Ivica Cepanec, Mladen Litvić, Mirela Filipan-Litvić   +3 more
doaj   +1 more source

Improving the Sensitivity in Chiral Analysis by Capillary Electrophoresis

ELECTROPHORESIS, EarlyView.
Most recent advances for the enhancement of sensitivity in capillary electrophoresis, including off‐line and in‐capillary preconcentration techniques and their combinations, and the use of alternative detection systems to UV–Vis spectrophotometric absorption.
María Castro‐Puyana, Sandra Salido‐Fortuna, María Luisa Marina   +2 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Synthesis and calcium channel antagonist activity of novel 1,4-dihydropyridine derivatives possessing 4-pyrone moieties

, 2010
New 1,4-dihydropyridine derivatives were synthesized by introducing 4-pyrone ring systems at the 4-position of the dihydropyridine nucleus. These compounds were obtained according to Hantzsch reaction. 4-Pyrone carbaldehydes: 4-(4-oxo-6-phenyl-4H-pyran-2-
Miri, Ramin, Shahrisa, Aziz, Mehdipour, Ahmadreza, Esmati, Somayeh, Saraei, Mahnaz, Sharifi, Maryam, Aziz Shahrisa, Ahmad Reza Mehdipour, Maryam Sharifi, Somayeh Esmati, Mahnaz Saraei, Ramin Miri   +11 more
core   +1 more source

Affinity Purification of Antibodies Specific for 1,4-Dihydropyridine Ca 2+ Channel Blockers [PDF]

, 2020
High-affinity antibodies specific for the 1,4-dihydropyridine Ca 2+ channel blockers have been produced in sheep and affinity purified using a dihydropyridine-Sepharose affinity column.
Kevin P Campbell, Alan H Sharp
core  

Diethyl 4-(4-ethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2009
In the title compound, C21H27NO5, the dihydropyridine ring adopts a boat conformation. The ethoxyphenyl ring is oriented approximately perpendicular to the planar part of the dihydropyridine ring, making a dihedral angle of 89.45 (6)°.
Hoong-Kun Fun, Jia Hao Goh, B. Palakshi Reddy, S. Sarveswari, V. Vijayakumar   +4 more
doaj   +1 more source

One-Pot Synthesis of 1, 4-Dihydropyridines in PEG Under Catalyst-Free Conditions [PDF]

Advances in Engineering Research, 2015
A simple, inexpensive, and efficient one-pot synthesis of 1,4-dihydropyridine via Hantzsch reaction was achieved in good to excellent yields under catalyst free conditions by using PEG400 as solvent. In this reaction, PEG-400 was used as the solvent, which has such advantages: absolutely nontoxic, inexpensive, thermally stable, recoverable and easy to ...
Shuwei Zhang, Ying Zhang, Lu Cao, Xiangfeng Kong, Liang Jun, Jing Lv   +5 more
openaire   +1 more source