Results 61 to 70 of about 19,839 (264)
Diethyl 4-(4-acetamidophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Acta Crystallographica Section E, 2012 The title compound, C21H26N2O5, was unexpectedly obtained as a by-product in the reaction of ethyl acetoacetate, 4-acetamidobenzaldehyde and urea under microwave irradiation. The dihydropyridine ring assumes a flattened boat conformation.
Yiliang Zhao +3 more
doaj +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Ameliorative effect of Houttuynia cordata Thunb (Saururaceae) leaf extract in loperamide-induced constipation in rats [PDF]
, 2021 Purpose: To investigate the efficacy of Houttuynia cordata Thunb (Saururaceae) extract against loperamide-induced constipation in Wistar rats. Methods: Constipation was induced by loperamide (3 mg/kg).
Kang, Hyun, Lee, Sung-Gyu
core +2 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Nimodipine in otolaryngology: from past evidence to clinical perspectives [PDF]
, 2015 As L-type voltage-gated calcium channels (VGCCs) control Ca(2+) influx and depolarisation of cardiac and vascular smooth muscle, they represent a specific therapeutic target for calcium channel blockers (CCBs), which are approved and widely used to treat
ALICANDRI CIUFELLI, Matteo +6 more
core +1 more source
Introduction to hCOMET special issue, ‘Comet assay in vitro’ [PDF]
, 2019 EditorialThis special issue is produced as a valuable outcome of the COST Action hCOMET. A major aim of this project is to encourage the adoption of standard procedures for the comet assay, in order to improve reliability.
Collins, Andrew +2 more
core +1 more source
Sleep Research, EarlyView.Abstract Study objectives To investigate the use of automated analysis to detect heart rate accelerations (HRAs) to screen for sleep‐disordered breathing (SDB) among patients who use chronotropic medications. Methods Nocturnal polysomnography (NPSG) recordings from 933 participants in the Sleep Heart Health Study were analyzed using an automated method
Nabila Ahmed +11 more
wiley +1 more source
Synthesis and in vitro Evaluation of the Antimycobacterial Activity of N-aryl-1,4-dihydropyridine-3,5-dicarboxamides [PDF]
Journal of Sciences, Islamic Republic of Iran, 2012 Dihydropyridines (DHPs) with carboxamides in the 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs that would possibly possess anti-tuberculosis activity.
F. Mohammadpour
doaj
Acta Chimica Slovenica, 2017 A series of diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivative coupled to 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones moieties at C2,C6 positions of 1,4-dihydropyridine ring system was prepared.
Maghsoud Ziaie +2 more
doaj +1 more source
Repurposing dihydropyridines for treatment of helicobacter pylori infection [PDF]
, 2019 Antibiotic resistance is a major cause of the increasing failures in the current eradication therapies against Helicobacter pylori. In this scenario, repurposing drugs could be a valuable strategy to fast-track novel antimicrobial agents.
Bénejat, Lucie +11 more
core +1 more source