Results 61 to 70 of about 90,592,261 (228)

Palladium‐Catalyzed Heck‐Type Double Arylation of 1,2‐Dihydropyridines

Helvetica Chimica Acta, EarlyView.
A Pd‐catalyzed Heck‐type double arylation of 1,2‐dihydropyridines enables concise access to 2‐substituted 3,6‐diarylated scaffolds with high site‐ and regioselectivity. ABSTRACT We report a site‐ and regioselective Heck‐type double arylation of substituted 1,2‐dihydropyridines.
Haining Li, Zackaria Nairoukh
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Diisopropyl 1-(4-methoxyphenyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

, 2011
In the title compound, C28H32N2O7, the 1,4-dihydropyridine ring adopts a flattened boat conformation. The two benzene rings are approximately perpendicular to the dihydropyridine ring, forming dihedral angles of 84.29 (9) and 82.96 (9)
Vivek K. Gupta, Rajni Kant, Hitendra S. Joshi, Kamini Kapoor, Milind P. Pawar   +4 more
core   +1 more source

Diethyl 4-(biphenyl-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2014
The title compound, C25H27NO4, has a flattened dihydropyridine ring. The benzene and phenyl rings are synclinal to one another, forming a dihedral angle of 49.82 (8)°; the axis of the biphenyl rings makes an 81.05 (9)° angle to the plane of the ...
Scott A. Steiger, Anthony J. Monacelli, Chun Li, Janet L. Hunting, Nicholas R. Natale   +4 more
doaj   +1 more source

Synthesis of 1, 4-dihydropyridines (DHP) Catalyzed by Trichloroisocyanuric Acid (TCCA) in Aqueous Media [PDF]

Scientia Iranica, 2016
An array of 1, 4-dihydropyridines (DHP) derivativeswas synthesized by Hantzsch three-component reaction of aromatic aldehydes, ethyl acetoacetate and ammonium acetate using trichloroisocyanuric acid (TCCA) as an efficient catalyst in aqueous media. The proposed method was operationally simple and to make the process benign for the environment, water ...
Marziyeh Roknaddini, Enayatollah sheikhhosseiny   +1 more
openaire   +1 more source

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source

NbCl5+AgClO4 AS A VERSATILE COMBINED CATALYST SYSTEM FOR AN ACCELERATED SYNTHESIS OF 1, 4- DIHYDROPYRIDINE SCAFFOLDS

RASAYAN Journal of Chemistry, 2022
Herein presented work describes the catalytic potential of NbCl5+AgClO4 as a combined and convenient catalyst system for a straightforward, safe, quick, and single-pot synthesis of 1, 4-dihydropyridine (DHP) scaffolds. It was investigated that a small amount of NbCl5+AgClO4 is sufficient and potential enough to bring out the solvent-free synthesis of 1,
Manisha Bora, Kailas Kadam, Punam Wani, Narendra Kamble   +3 more
openaire   +1 more source

Bruton tyrosine kinase inhibitors and cardiovascular adverse events

British Journal of Pharmacology, EarlyView.
Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli, Cristina Madaudo, Emanuela Salvatorelli, Giorgio Minotti, Pierantonio Menna   +4 more
wiley   +1 more source

Synthesis and in vitro Evaluation of the Antimycobacterial Activity of N-aryl-1,4-dihydropyridine-3,5-dicarboxamides [PDF]

Journal of Sciences, Islamic Republic of Iran, 2012
Dihydropyridines (DHPs) with carboxamides in the 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs that would possibly possess anti-tuberculosis activity.
F. Mohammadpour
doaj  

Synthesis and biological evaluation of 1,2,4-triazoles and 1,3,4-oxadiazoles derivatives linked to 1,4-dihydropyridines scaffold

Acta Chimica Slovenica, 2017
A series of diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivative coupled to 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones moieties at C2,C6 positions of 1,4-dihydropyridine ring system was prepared.
Maghsoud Ziaie, Karim Akbaridilmaghani, Amir Tukmechi   +2 more
doaj   +1 more source