Results 61 to 70 of about 9,315,415 (239)

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Diethyl 4-(4-ethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2009
In the title compound, C21H27NO5, the dihydropyridine ring adopts a boat conformation. The ethoxyphenyl ring is oriented approximately perpendicular to the planar part of the dihydropyridine ring, making a dihedral angle of 89.45 (6)°.
Hoong-Kun Fun, Jia Hao Goh, B. Palakshi Reddy, S. Sarveswari, V. Vijayakumar   +4 more
doaj   +1 more source

Effective fabrication of poly(anilin-formaldehyde)-supported hybrid nanomaterial and catalytic synthesis of dihydropyridines [PDF]

Nanochemistry Research, 2019
In this study, Fe3O4@SiO2-PAF-SO3H nanocomposite was successfully fabricated by immobilization of sulfonic acid groups on the surface of poly(anilin-formaldehyde)-supported on magnetic Fe3O4@SiO2 nanoparticles through layer-by-layer assembly.
Mohammad Ali Bodaghifard, Zahra Faraki, Sajad Asadbegi   +2 more
doaj   +1 more source

Synthesis of 1, 4-dihydropyridines (DHP) Catalyzed by Trichloroisocyanuric Acid (TCCA) in Aqueous Media [PDF]

Scientia Iranica, 2016
An array of 1, 4-dihydropyridines (DHP) derivativeswas synthesized by Hantzsch three-component reaction of aromatic aldehydes, ethyl acetoacetate and ammonium acetate using trichloroisocyanuric acid (TCCA) as an efficient catalyst in aqueous media. The proposed method was operationally simple and to make the process benign for the environment, water ...
Marziyeh Roknaddini, Enayatollah sheikhhosseiny   +1 more
openaire   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Synthesis of 2‐Aza‐Bicyclo[4.3.0]nonane Derivatives Related to the Camporidines via Intramolecular [3+2]‐Cycloaddition

European Journal of Organic Chemistry, EarlyView.
The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher, Tobias Wilczek, Nora Katharina Korber, Jörg-Martin Neudörfl, Bernd Goldfuss, Hans-Günther Schmalz   +5 more
wiley   +1 more source

Synthesis of substituted indolizines from 1-phenacyl-5-methyl-4-phenyl-2-phenacylidene-1,2-dihydropyridine

, 2020
1-Phenacyl-5-methyl-4-phenyl-2-phenacylidene-1,2-dihydropyridine was obtained, and its cyclization to substituted indolizines was examined.
Prostakov N.S., Baktibaev O.B.
core   +2 more sources

Diethyl 4-(biphenyl-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2014
The title compound, C25H27NO4, has a flattened dihydropyridine ring. The benzene and phenyl rings are synclinal to one another, forming a dihedral angle of 49.82 (8)°; the axis of the biphenyl rings makes an 81.05 (9)° angle to the plane of the ...
Scott A. Steiger, Anthony J. Monacelli, Chun Li, Janet L. Hunting, Nicholas R. Natale   +4 more
doaj   +1 more source

Gold(I)‐Mediated Reactivity of Allenes With Mesoionic Nucleophiles: A Computational Exploration

European Journal of Organic Chemistry, EarlyView.
The regioselective gold(I)‐mediated reactivity of allenes with mesoionic nucleophiles has been evaluated through computational analysis of the mechanisms involved. Instead of typical (3 + 2) pathways, sydnones and münchnones favour the formal (3 + 3) cyclizations affording substituted dihydropyridines.
Eduardo Garcia‐Padilla, Feliu Maseras
wiley   +1 more source

A flavone 1,4-dihydropyridine calcium antagonist

, 1999
In the title compound, diethyl 2,6-dimethyl-4-(2-phenyl-4-oxo-4H-1-benzopyran-6-yl)-1,4-dihydropyridine-3,5-dicarboxylate, C28H27NO6, the 1,4-dihydropyridine ring exhibits a boat conformation. The benzopyran moiety of the flavone is nearly planar, and is
AYHAN, GÖKÇE, ERTAN, R, KENDI, E, Ozbey, SÜHEYLA   +3 more
core   +1 more source