Results 31 to 40 of about 19,839 (264)

Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity [PDF]

Scientific Reports, 2017
AbstractThe present study, we design and synthesize the novel dihydropyridine derivatives, i.e., 3 (a-e) and 5 (a-e) and evaluated, anticonvulsant activity. Initially due to the lacuna of LCC, we modeled the protein through modeller 9.15v and evaluated through servers.
Saddala, Madhu, Kandimalla, Ramesh, Adi, Pradeepkiran, Bhashyam, Sainath, Asupatri, Usha   +4 more
openaire   +5 more sources

Diethyl 4-(4-cyanophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2010
In the title compound, C20H22N2O4, the dihedral angle between the roughly planar dihydropyridine ring (r.m.s. deviation = 0.092 Å) and the benzene ring is 87.09 (6)°.
Peng Zhang, Weiqun Zhu
doaj   +1 more source

Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana) [PDF]

, 2017
Infectious diseases remain a significant threat to human health, contributing to more than 17 million deaths, annually. With the worsening trends of drug resistance, there is a need for newer and more powerful antimicrobial agents.
A Brüning, A Fodor, A Husain, A Idhayadhulla, A Kaplan, A Nemeikaitė-Čėnienė, A Pantosti, A Pawellek, A Rauf, A Richters, A Rico, A Sakunphueak, AJ Alanis, AM Alanazi, AM Carvalho, AM Griggs, AS Mayhoub, Ayaz Anwar, B Combourieu, B Sadek, B Villemagne, B Zarzycka, BE Bilich, BE Brown, BL Ginsborg, BV Le, C Amutha, C Rademacher, C Shiota, CA Morgan, CH Yen, CL Yuan, CMM Gómez, CT Makowski, D Duś, D Mehetre, D Raffa, D Vergara, DA Pisanenko, DJ Hardick, DT Youssef, E Braud, E Clynen, E Oberbauer, E Pery, E Rosatelli, EA Musad, EC Kormann, EM Flefel, EV Verbitskiy, F Puig-Basagoiti, FN Alvarez, FT Hatch, FZ Mharti, G Devasahayam, G Engelsma, G Liu, G Ramdani, G Ren, G Schlewer, G Şahin, GN Vassilev, H Chikhale, H Hatano, H Hussain, H Istanbullu, H Li, H Niaz, H Smetana, H Wang, HB Shin, HY Chen, I Karakaya, I Orhan, IC Zampini, J Győrfi, J Han, J La, J Mareddy, JD Guzman, JF Sun, JL Vennerstrom, JM Ontoria, JP Rappai, JR Bauquier, JW Weaver, JY Yang, K Iwasa, K Philip, K Tangdenpaisal, K Wada, KW Leal, KW Park, L Sun, LJ Huang, M Akhter, M al-Rashida, M Amiche, M Brunskole Švegelj, M Gökce, M Jahangir, M Ma, M Miyazawa, M Pawelczap, M Sagheer, M Salzet, M Zhu, MA Aziz-ur-Rehman Abbasi, MA Orabi, MC Enright, MD Bachi, MH Metz-Boutigue, MIC De Troconis, MJ Arrowood, MJ Frederico, MM Alam, MM Khafagy, MN Zemtsova, MT Mackmull, Muhammad Raza Shah, N Desplaces, N Mashhoon, N Sunduru, N Özbek, NA Khan, NA Khan, NA Lack, Naveed Ahmed Khan, ND Eddington, NG Anthony, NK Roy, NR Gonewar, O Perwitasari, OO Ajani, OO Peter, P Armati, P Bulet, P Chen, P Deprez, P Funk, P Kumar, P Nordmann, P Samadhiya, PB Savage, Peter J. Heard, PL Taylor, Q Zheng, QC Fu, R Bonnett, R Bonnett, R De Simone, R Ruckli, R Wilson, RA Tapia, RL Groves, Ruqaiyyah Siddiqui, S Antoniou, S Bondock, S Celikler, S Cesarini, S Elliott, S Ganguli, S George, S Indumathi, S Kasai, S Lee, S Minami, S Nagarajan, S Wirth, S Yang, SA Lujan, Salwa Mansur Ali, SC Bang, SC Basak, Seng-Kai Ong, SF Liou, SM Capitosti, T Antonucci, T Ellendorff, T Ishikawa, TB Emran, TC Lima, TC Yang, TES Ali, TP Yin, TR Burke, TS Tiuman, TT Cushnie, TW Sanchez, U Guzzi, U Singh, V Bhardwaj, V Exarchou, V Facchinetti, V Mihailovic, V Miliukienė, VK Bajpai, VV Kouznetsov, VV Kouznetsov, W He, X He, XD Wang, XJ Gao, XN Wang, XP Sun, Y Dai, Y Fang, Y Girard, Y Take, Y Tang, Y Zhao, Y Özkay, YH Seo, YLN Murthy, YM Sinam, Z Su   +215 more
core   +1 more source

Dimethyl 4-(4-formylphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2008
The title compound, C18H19NO5, is a product of the Hantzsch reaction of p-phthalaldehyde, methyl acetoacetate, and ammonium acetate. The 1,4-dihydropyridine ring of the molecule adopts a flattened boat conformation.
Fei Teng, Fanpeng Kong, Qingjian Liu
doaj   +1 more source

Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides [PDF]

, 1998
A series of N-alkyl-2-oxoalkanesulfonamides have been synthesized by reacting silyl enol ethers with N-alkyl-sulfamoyl chlorides. Their reactivity towards electrophiles was investigated in order to explore the regio-and stereoselectivity of the process ...
Alajarín Ferrández, Ramón, Vaquero López, Juan José, Vega Ramiro, Juan Antonio, Álvarez-Builla Gómez, Julio   +3 more
core   +3 more sources

Synthesis and antimicrobial activity of a new series of 1,4-dihydropyridine derivatives [PDF]

Journal of the Serbian Chemical Society, 2011
A series of 1,4-dihydropyridine derivatives (1a–g) were prepared from Hantzsch syntheses. The compounds 1a–g were reacted with thiosemicarbazide to give the new series of compounds 2a–g. IR, 1H-NMR, 13C-NMR, mass spectral and elemental analysis confirmed
RADHAKRISHNAN SURENDRA KUMAR, AKBAR IDHAYADHULLA, ABDUL JAMAL ABDUL NASSER, JOSEPH SELVIN   +3 more
doaj  

Pharmacokinetics of Mebudipine, a new calcium antagonist, following single intravenous and oral administrations in rats [PDF]

The pharmacokinetics of a new calcium antagonist, mebudipine, was studied after a single intravenous (0.5mg/kg) and oral (10mg/kg) administration to rats.
بهلولی, شهاب, محمودیان, مسعود, کیهانفر, فریبرز   +2 more
core   +1 more source

Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline
A. Shafiee
doaj  

Stability Indicating Assay Method Development and Validation of Amlodipine Besylate in Bulk and Tablet Dosage form by UV Spectroscopy and RP-HPLC [PDF]

, 2023
A simple, cost effective, highly precise and robust stability indicating UV Spectroscopy and RP-HPLC method was developed for the estimation of Amlodipine in bulk and tablet dosage form. The chromatographic separation was achieved on Agilent C18 (250mm×4.
Rubeen Dadakalandar Nadaf, Sudhahar Dharmalingam, Shweta Harshal Zalte, Shyma Sundar Sahu, Swarnima Pandey, Deepak Sharma, Shanmugam Vippamakula, Awinish Kumar Shrivastaw, Raveesha Peeriga, Ramanlal N. Kachave
core   +2 more sources

Diethyl 4-[4-(dimethylamino)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2010
In the title compound, C21H28N2O4, the dihydropyridine ring adopts a flattened boat conformation. The mean plane of the dihydropyridine ring and the attached benzene ring form a dihedral angle of 85.1 (1) Å.
Ming-Sheng Bai, Yan-Ping Cao, Qian Zhang, Wang-Bin Sun, Xiao-Ling Ji   +4 more
doaj   +1 more source