Results 21 to 30 of about 90,592,261 (228)

Antihypertensive effects of new dihydropyridine derivatives on phenylephrine-raised blood pressure in rats

Research in Pharmaceutical Sciences, 2016
Changes in the substitutions at C-3 and C-5 positions of 4-(1-methyl-5-nitro-2-imidazolyl) dihydropyridine analogs of nifedipine have led to changes in potency of the compounds. The objective of the present study was to examine the hypotensive effects of
Sara Rowghani Haghighi Fard, Ramin Miri, Ali Akbar Nekooeian   +2 more
doaj   +1 more source

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines

Data in Brief, 2020
In this data file the synthetic procedures for preparation of the original 4-pyridinium-1,4-dihydropyridines (4-Py-1,4-DHP) and their parent compounds – dialkyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylates were described. In total, 5
Klavs Pajuste, Martins Rucins, Ilona Domracheva, Arkadij Sobolev, Nadiia Pikun, Mara Plotniece, Gunars Duburs, Karlis Pajuste, Aiva Plotniece   +8 more
doaj   +1 more source

Experimental and computational chemical studies on the corrosion inhibitive properties of carbonitrile compounds for carbon steel in aqueous solutions

Scientific Reports, 2021
The present work aims to study 6-amino-4-aryl-2-oxo-1-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives namely: 6-Amino-2-oxo-1,4-diphenyl-1,2-dihydropyridine-3,5-dicarbonitrile (PdC-H), 6-Amino-2-oxo-1-phenyl-4-(p-tolyl)-1,2-dihydropyridine-3,5 ...
Abd El-Aziz S. Fouda, Abdelmonem H. El-Askalany, Ahmed F. S. Molouk, Niveen S. Elsheikh, Ashraf S. Abousalem   +4 more
doaj   +1 more source

Study of novel 1,4-dihydropyridine derivatives as prospective anti-inflammatory remedies: a randomised controlled trial

Кубанский научный медицинский вестник, 2022
Background. Over the past decades, scientific community is motivated on finding new anti-inflammatory agents with a safe and high-effective profile to manage pathology.Objectives. A study of the anti-inflammatory action of novel compounds, 1,4-dihydropyridine
E. Yu. Bibik, D. S. Krivokolysko, G. A. Batishcheva, A. A. Samokish, Yu. S. Venidiktova, A. V. Myazina, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko   +9 more
doaj   +1 more source

Spiro compounds with fragments of 4-azafluorene-[indeno(2,3-e)-1,2-dihydropyridine] and pyrazoline

, 2020
9-Phenacylidene-4-azafluorene and 9-bromo-9-(α-bromophenacyl)-4-azafluorene have been used in the synthesis of spiro compounds with fragments of substituted pyrazolines.
Mikhailova N.M., Prostakov N.S., Mustafa A.   +2 more
core   +1 more source

Electron Donor–Acceptor Complex Catalysis in Synthetic Chemistry

Angewandte Chemie, EarlyView.
Electron donor–acceptor (EDA) complexes are moving beyond stoichiometric photoactivation toward catalytic platforms for radical generation. Productive EDA catalysis requires coordinated donor–acceptor association, charge‐transfer excitation, radical reactivity, and vcatalyst turnover.
Tristan von Münchow, Andrea Palone, Jonathan Samuel Trimble, Paolo Melchiorre   +3 more
wiley   +2 more sources

Prescription Intervals of Medications for Chronic Use: A Cohort Study [PDF]

Pharmacoepidemiol Drug Saf
ABSTRACT Purpose In deprescribing studies, a prescription‐free gap is typically used to determine if patients discontinued their treatment. An appropriate gap depends on the typical time between prescriptions during continued use. This work aims to characterise the interval between prescriptions of chronic drugs (long‐term use) using different methods ...
Muddiman R, Donoghue P, Lemus J, Doherty A, Boland F, McCarthy C, Moriarty F.   +6 more
europepmc   +2 more sources

One-Pot Synthesis of 1,4-Dihydropyridine Derivatives and their X-Ray Crystal Structures: Role of Fluorine in Weak Interactions [PDF]

, 2020
1,4-dihydropyridines, namely diethyl 4-(4-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1a), diethyl 2,6-dimethyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate(1b), and diethyl 4-(3,4-dimethoxyphenyl)-2,6-dihydroxy ...
Shashi, R., Prasad, N.L., Begum, N.S.
core   +1 more source

Synthesis of substituted indolizines from 1-phenacyl-5-methyl-4-phenyl-2-phenacylidene-1,2-dihydropyridine

, 2020
1-Phenacyl-5-methyl-4-phenyl-2-phenacylidene-1,2-dihydropyridine was obtained, and its cyclization to substituted indolizines was examined.
Prostakov N.S., Baktibaev O.B.
core   +2 more sources

Tissue-specific expression of calcium channels [PDF]

, 1993
The high-voltage-activated calcium channel is a multimeric protein complex containing 1, 2/δ, β, and γ subunits. The 1 subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins.
Flockerzi, Veit, Biel, Martin, Hullin, Roger, Hofmann, Franz   +3 more
core   +1 more source