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Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography
2005The chiral resolution of racemic drugs into their enantiomers is of great importance, because the two enantiomers often exhibit different pharmacological activity. This work deals with a group of very popular biologically active 1, 4-dihydropyridine drugs.
Vinković, Vladimir +2 more
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1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules
Mini-Reviews in Medicinal Chemistry, 2014The 1,4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel modulating agents and have experienced widespread use in the treatment of cardiovascular disease which include antihypertensive, antianginal, vasodilator and cardiac ...
Samrat A, Khedkar, Pratibha B, Auti
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Synthesis of 3-cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thionks
Chemistry of Heterocyclic Compounds, 19833-Cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thiones have been synthesized for the first time by the condensation of arylideneacetophenones or 1-piperidino-1-phenyl-2-benzoylethane with cyanothioacetamide and the 1, 1-dicyano-2-aryl-3-benzoylpropane with hydrogen sulfide in the presence of bases. It has been established by PMR spectroscopy that 3-cyano-3,
A. A. Krauze +5 more
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Synthesis of 1, 4-Dihydropyridines using Different Nanocatalyst Systems
Research Journal of Chemistry and Environment1, 4-dihydropyridine (1, 4-DHP) is an important class of heterocyclic scaffold which possesses a wide variety of applications in biological and pharmacological field. In this review, we discuss the synthesis of 1, 4-dihydropyridine by using various nanocatalytic systems since 2010. Nanocatalyst provided efficient and green approach for the synthesis of
Deepak Babasaheb Phasage +2 more
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Current Computer-Aided Drug Design, 2018
Tuberculosis is one of the main medical problems and some people are suffering still from this infectious disease. 1, 4-dihydropyridines are multi-target ligands that recently are recognized as anti-tubercular agents.In the current research, computational studies were conducted of some synthesized 1, 4- dihydropyridine-3, 5-dicarboxamides in non ...
Yasaman, Rasouli, Asghar, Davood
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Tuberculosis is one of the main medical problems and some people are suffering still from this infectious disease. 1, 4-dihydropyridines are multi-target ligands that recently are recognized as anti-tubercular agents.In the current research, computational studies were conducted of some synthesized 1, 4- dihydropyridine-3, 5-dicarboxamides in non ...
Yasaman, Rasouli, Asghar, Davood
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Pflügers Archiv - European Journal of Physiology, 2003
Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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ChemInform, 1988
AbstractThe dihydropyridinethiolates (V), prepared by common cyclization reactions, are converted to the thiones (VIII), the betaines (IX), and the sodium salts (X).
A. A. KRAUZE +3 more
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AbstractThe dihydropyridinethiolates (V), prepared by common cyclization reactions, are converted to the thiones (VIII), the betaines (IX), and the sodium salts (X).
A. A. KRAUZE +3 more
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Chemistry of Heterocyclic Compounds, 1978
The polarographic reduction of 1, 4-dihydropyridine-3, 5-dicarboxylic acid derivatives in dimethylformamide was studied. It is shown that the first diffusion waves of these compounds are irreversible one-electron waves and correspond to electrical reduction of the C=C bond of the conjugated system of the 1, 4-dihydropyridine ring to give a tetrahydro ...
V. P. Kadysh +3 more
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The polarographic reduction of 1, 4-dihydropyridine-3, 5-dicarboxylic acid derivatives in dimethylformamide was studied. It is shown that the first diffusion waves of these compounds are irreversible one-electron waves and correspond to electrical reduction of the C=C bond of the conjugated system of the 1, 4-dihydropyridine ring to give a tetrahydro ...
V. P. Kadysh +3 more
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Journal of Molecular Structure, 1999
Abstract X-ray crystal structures of dimerizing 4-aryl-1,4-dihydropyridines and their solid-state irradiation products, either antidimers or cage dimers, were determined to investigate their topochemistry. The products of the solid-state reactions prove to be geometrically defined by the crystal packing of the monomers.
A. Hilgeroth +2 more
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Abstract X-ray crystal structures of dimerizing 4-aryl-1,4-dihydropyridines and their solid-state irradiation products, either antidimers or cage dimers, were determined to investigate their topochemistry. The products of the solid-state reactions prove to be geometrically defined by the crystal packing of the monomers.
A. Hilgeroth +2 more
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Aromatization of 1, 4-dihydropyridine derivatives
2006Pripravljeno je ukupno 29 različito supstituiranih 1, 4-dihidropiridinskih derivata korištenjem nekoliko varijanti Hantzschove kondenzacije. Prilikom pokušaja priprave derivata 35 sa prisutnom metoksi skupinom u ortho-položaju arilne grupe, korištenjem Hantzschove metode sa dva mola aminokrotonatnog estera, izoliran je literaturno novi spoj 49 kao ...
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