Results 241 to 250 of about 5,843 (268)
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N‐alkylation of 1, 4‐dihydropyridine derivatives
Bulletin des Sociétés Chimiques Belges, 1973AbstractA series of 1‐alkyl‐2, 6‐dimethyl‐3, 5‐diethoxycarbonyl‐4‐aryl‐1, 4‐dihydropyridines have been synthesised by the reaction of the corresponding 1, 4‐dihydro‐pyridines with consecutively sodium hydride and alkyl halides.
R. A. Dommisse, F. C. Alderweireldt
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Synthesis of 2,3-dihydrobenzofuran-3-spiro-4′-dihydropyridines
Tetrahedron Letters, 1981Abstract 2,3-Dihydrobenzofuran-3-spiro-4′-dihydropyridines are readily available via intramolecular addition of enolates to pyridinium ions.
Dwight D. Weller, Glenn R. Luellen
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Synthese et reaction de diacyl-1,4 alkyl-4 dihydropyridines
Tetrahedron, 1973Resume L'action du zinc et des anhydrides acetique, propionique et butyrique sur des pyridines substituees en C-4 donne des diacyl-1,4 alkyl-4 dihydropyridines, qui peuvent egalement etre obtenues par reaction radicalaire. L'acetyl-1 methylene-4 methyl-5 dihydro-4,5 azepine 24 a ete preparee par solvolyse du tosylate 23 , derivant de la diacetyl-1,
P.M. Atlani, J.F. Biellmann, J. Moron
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ChemInform Abstract: SYNTHESIS OF 2,3‐DIHYDROBENZOFURAN‐3‐SPIRO‐4′‐DIHYDROPYRIDINES
Chemischer Informationsdienst, 1982AbstractBei der Kondensation von Salicylaldehydmethylether (I) mit 2‐Acetyl‐furan (II) erhält man unter alkalischen Bedingungen das Diketon (III), das durch weitere Kondensation mit Hydroxylamin, anschließende Permanganatoxidation und Thermolyse über das Pyridin (IVa) und die Dicarbonsäure (IVb) zum Decarboxylierungsprodukt (IVc) führt.
D. D. WELLER, G. R. LUELLEN
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Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography
2005The chiral resolution of racemic drugs into their enantiomers is of great importance, because the two enantiomers often exhibit different pharmacological activity. This work deals with a group of very popular biologically active 1, 4-dihydropyridine drugs.
Vinković, Vladimir +2 more
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1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules
Mini-Reviews in Medicinal Chemistry, 2014The 1,4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel modulating agents and have experienced widespread use in the treatment of cardiovascular disease which include antihypertensive, antianginal, vasodilator and cardiac ...
Samrat A, Khedkar, Pratibha B, Auti
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Synthesis of 3-cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thionks
Chemistry of Heterocyclic Compounds, 19833-Cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thiones have been synthesized for the first time by the condensation of arylideneacetophenones or 1-piperidino-1-phenyl-2-benzoylethane with cyanothioacetamide and the 1, 1-dicyano-2-aryl-3-benzoylpropane with hydrogen sulfide in the presence of bases. It has been established by PMR spectroscopy that 3-cyano-3,
A. A. Krauze +5 more
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Synthesis of 1, 4-Dihydropyridines using Different Nanocatalyst Systems
Research Journal of Chemistry and Environment1, 4-dihydropyridine (1, 4-DHP) is an important class of heterocyclic scaffold which possesses a wide variety of applications in biological and pharmacological field. In this review, we discuss the synthesis of 1, 4-dihydropyridine by using various nanocatalytic systems since 2010. Nanocatalyst provided efficient and green approach for the synthesis of
Deepak Babasaheb Phasage +2 more
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Current Computer-Aided Drug Design, 2018
Tuberculosis is one of the main medical problems and some people are suffering still from this infectious disease. 1, 4-dihydropyridines are multi-target ligands that recently are recognized as anti-tubercular agents.In the current research, computational studies were conducted of some synthesized 1, 4- dihydropyridine-3, 5-dicarboxamides in non ...
Yasaman, Rasouli, Asghar, Davood
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Tuberculosis is one of the main medical problems and some people are suffering still from this infectious disease. 1, 4-dihydropyridines are multi-target ligands that recently are recognized as anti-tubercular agents.In the current research, computational studies were conducted of some synthesized 1, 4- dihydropyridine-3, 5-dicarboxamides in non ...
Yasaman, Rasouli, Asghar, Davood
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Pflügers Archiv - European Journal of Physiology, 2003
Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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