Results 21 to 30 of about 4,580 (244)

5-Oxo-hexahydroquinoline derivatives and their tetrahydroquinoline counterparts as multidrug resistance reversal agents [PDF]

, 2020
Cancer is a leading cause of death worldwide. Multidrug resistance (MDR) is a main reason of chemotherapy failure in many patients and is often related to overexpression of ATP-binding cassette (ABC) transporters, including P-glycoprotein (P-gp/ABCB1).
Dehghani, Mojtaba, Edraki, Najmeh, Firuzi, Omidreza, Khoshneviszadeh, Mehdi, Mohabbati, Maryam, Saso, Luciano, Shahraki, Omolbanin, Tavakkoli, Marjan   +7 more
core   +1 more source

PHOTODEGRADATION OF 1, 4-DIHYDROPYRIDINE ANTIHYPERTENSIVE DRUGS: AN UPDATED REVIEW

International Journal of Pharmacy and Pharmaceutical Sciences, 2018
1, 4-dihydropyridine calcium channels blockers (DHPs) are the most commonly used antihypertensive drugs. Unfortunately, these compounds have a significant degradability to light. The oxidation to the pyridine derivative represents the first, and in many cases the only, step of the degradation mechanism.
MICHELE DE LUCA, GIUSEPPINA IOELE, CLAUDIA SPATARI, GAETANO RAGNO   +3 more
openaire   +4 more sources

New synthetic method for the synthesis of 1,4-dihydropyridine using aminated multiwalled carbon nanotubes as high efficient catalyst and investigation of their antimicrobial properties

Journal of Saudi Chemical Society, 2018
Synthesis of 1,4-dihydropyridines in the presence of aminated multiwalled carbon nanotubes and investigation into their antimicrobial properties were carried out.Amino functionalized carbon nanotubes were prepared through a facile, clean and safe ...
Roya Mahinpour, Leila Moradi, Zohreh Zahraei, Nafiseh Pahlevanzadeh   +3 more
doaj   +1 more source

Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators [PDF]

, 2004
A major problem in cancer treatment is the development of resistance to multiple chemotherapeutic agents in tumor cells. A major mechanism of this multidrug resistance (MDR) is overexpression of the MDR1 product P-glycoprotein, known to bind to and ...
Safa, Ahmad R.
core   +1 more source

Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana) [PDF]

, 2017
Infectious diseases remain a significant threat to human health, contributing to more than 17 million deaths, annually. With the worsening trends of drug resistance, there is a need for newer and more powerful antimicrobial agents.
A Brüning, A Fodor, A Husain, A Idhayadhulla, A Kaplan, A Nemeikaitė-Čėnienė, A Pantosti, A Pawellek, A Rauf, A Richters, A Rico, A Sakunphueak, AJ Alanis, AM Alanazi, AM Carvalho, AM Griggs, AS Mayhoub, Ayaz Anwar, B Combourieu, B Sadek, B Villemagne, B Zarzycka, BE Bilich, BE Brown, BL Ginsborg, BV Le, C Amutha, C Rademacher, C Shiota, CA Morgan, CH Yen, CL Yuan, CMM Gómez, CT Makowski, D Duś, D Mehetre, D Raffa, D Vergara, DA Pisanenko, DJ Hardick, DT Youssef, E Braud, E Clynen, E Oberbauer, E Pery, E Rosatelli, EA Musad, EC Kormann, EM Flefel, EV Verbitskiy, F Puig-Basagoiti, FN Alvarez, FT Hatch, FZ Mharti, G Devasahayam, G Engelsma, G Liu, G Ramdani, G Ren, G Schlewer, G Şahin, GN Vassilev, H Chikhale, H Hatano, H Hussain, H Istanbullu, H Li, H Niaz, H Smetana, H Wang, HB Shin, HY Chen, I Karakaya, I Orhan, IC Zampini, J Győrfi, J Han, J La, J Mareddy, JD Guzman, JF Sun, JL Vennerstrom, JM Ontoria, JP Rappai, JR Bauquier, JW Weaver, JY Yang, K Iwasa, K Philip, K Tangdenpaisal, K Wada, KW Leal, KW Park, L Sun, LJ Huang, M Akhter, M al-Rashida, M Amiche, M Brunskole Švegelj, M Gökce, M Jahangir, M Ma, M Miyazawa, M Pawelczap, M Sagheer, M Salzet, M Zhu, MA Aziz-ur-Rehman Abbasi, MA Orabi, MC Enright, MD Bachi, MH Metz-Boutigue, MIC De Troconis, MJ Arrowood, MJ Frederico, MM Alam, MM Khafagy, MN Zemtsova, MT Mackmull, Muhammad Raza Shah, N Desplaces, N Mashhoon, N Sunduru, N Özbek, NA Khan, NA Khan, NA Lack, Naveed Ahmed Khan, ND Eddington, NG Anthony, NK Roy, NR Gonewar, O Perwitasari, OO Ajani, OO Peter, P Armati, P Bulet, P Chen, P Deprez, P Funk, P Kumar, P Nordmann, P Samadhiya, PB Savage, Peter J. Heard, PL Taylor, Q Zheng, QC Fu, R Bonnett, R Bonnett, R De Simone, R Ruckli, R Wilson, RA Tapia, RL Groves, Ruqaiyyah Siddiqui, S Antoniou, S Bondock, S Celikler, S Cesarini, S Elliott, S Ganguli, S George, S Indumathi, S Kasai, S Lee, S Minami, S Nagarajan, S Wirth, S Yang, SA Lujan, Salwa Mansur Ali, SC Bang, SC Basak, Seng-Kai Ong, SF Liou, SM Capitosti, T Antonucci, T Ellendorff, T Ishikawa, TB Emran, TC Lima, TC Yang, TES Ali, TP Yin, TR Burke, TS Tiuman, TT Cushnie, TW Sanchez, U Guzzi, U Singh, V Bhardwaj, V Exarchou, V Facchinetti, V Mihailovic, V Miliukienė, VK Bajpai, VV Kouznetsov, VV Kouznetsov, W He, X He, XD Wang, XJ Gao, XN Wang, XP Sun, Y Dai, Y Fang, Y Girard, Y Take, Y Tang, Y Zhao, Y Özkay, YH Seo, YLN Murthy, YM Sinam, Z Su   +215 more
core   +1 more source

1,1′-{[3,5-Bis(dodecyloxycarbonyl)-4-(naphthalen-2-yl)-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis{4-[(E)-2-(naphthalen-2-yl)vinyl]pyridin-1-ium}dibromide [PDF]

, 2022
Funding Information: Funding: This research was funded by the EuroNanoMed3 project TENTACLES No ES RTD/2020/18. Publisher Copyright: © 2022 by the authors.
Kaukulis, Martins, Pajuste, Karlis, Pikun, Nadiia, Plotniece, Aiva, Rucins, Martins, Sobolev, Arkadij   +5 more
core   +1 more source

TiCl2/Nano-γ-Al2O3 as a Novel Lewis Acid Catalyst for Promotion of One-pot Synthesis of 1,4-dihydropyridines [PDF]

Journal of Nanostructures, 2018
Synthesis of organic compounds using nano-catalysts is more and more attention due to the numerous advantages such as cost-effectiveness, high catalytic activity, ease of product separation, recovery of the catalyst, repeated recycling potential and good
Bi Bi Fatemeh Mirjalili, Abdolhamid Bamoniri, Leila Asadollah Salmanpoor   +2 more
doaj   +1 more source

Enaminones in a multicomponent synthesis of 4-aryldihydropyridines for potential applications in photoinduced intramolecular electron-transfer systems

Beilstein Journal of Organic Chemistry, 2012
An efficient three component reaction with enaminones, primary amines and aldehydes resulted in easy access to 1,4-dihydropyridines with different substituents at the 1-, 3-, 4- and 5-positions.
Nouria A. Al-Awadi, Maher R. Ibrahim, Mohamed H. Elnagdi, Elizabeth John, Yehia A. Ibrahim   +4 more
doaj   +1 more source

Rearrangement of o-Nitrobenzaldehyde in the Hantzsch Reaction

Molecules, 2001
The reaction of 5-hydroxy-2-nitrobenzaldehyde with ethyl acetoacetate in ammonia gave the two expected isomeric 1,4- and 1,2-dihydropyridines resulting from the normal Hantzsch reaction.
R. Martínez, R. López- Castañares, A. Velázquez, A. Ramírez, I. Martínez, I. Menconi, H. Santillán, E. Angeles   +7 more
doaj   +1 more source

Green synthesis of nano binary oxide SiO2/V2O5 NPs integrated ointment cream application on wound dressings and skin cancer cells [PDF]

, 2023
 اشتملت الدراسة الحالية على تحضير المزدوج النانو SiO2/V2O5  باستخدام مواد طبيعية خام كمادة أولية حيث استخدمت رماد قشور الارز بعد حرقها بدرجة  °C700  سيليزية  للتخلص من المواد العضوية واللاعضوية في القشور حيث كانت هي  المادة الخام لاستخلاص السليكا جل ...
Ali, Marwa, Drea, Abbas A-Ali
core   +2 more sources