Results 41 to 50 of about 4,580 (244)

Anticonvulsant effects of nimodipine alone and combination with phenytoin on MES induced seizures [PDF]

, 2018
Background: To evaluate the anticonvulsant activity of Nimodipine alone and in combination with Phenytoin, in MES induced seizures.Methods: The study was conducted in mice and MES seizure was induced by Techno electroconvulsometer. In first part of study,
Jain, Ashish, Jain, Raina
core   +2 more sources

Cytotoxic effect of some 1, 4-dihydropyridine derivatives containing nitroimidazole moiety.

Iranian journal of pharmaceutical research : IJPR, 2011
The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca(2+) channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing ...
Miri, Ramin, Javidnia, Katayoun, AmirGhofran, Zahra, Salimi, Seyyed Hossein, Sabetghadam, Zahra, Meili, Savis, Mehdipour, Ahmad Reza   +6 more
openaire   +2 more sources

Synthesis of 2-Mono and 2,6-Disubstituted Methyl-1,4-Dihydropyridines [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1997
The 2-mono and 2,6-disubstituted methyl-1,4-dihydropyridines were synthesized by reaction of morpholine, thiophenol, 8-hydroxyquinoline, 2-naphthol and 2-mercopto-1-methyl imidazole with the 2-mono bromo and 2,6-dibromo-1,4-dihidropyridines.
Yousef Rastgar Mirzaei, Karim Akbari Dilmaghani   +1 more
doaj  

1, 4-Dihydropyridine Derivatives : Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress1, 4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Oxidative medicine and cellular longevity, 2016
Many 1, 4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA).
Žarković, Neven, Gall Trošelj, Koraljka   +1 more
openaire   +2 more sources

A Systematic Review on 1, 4-Dihydropyridines and its Analogues: An Elite Scaffold

Biointerface Research in Applied Chemistry, 2021
1,4-Dihydropyridines are a group of pyridine-based molecules possessing a magnificent set of biological and therapeutic potentials. Belonging to the class of calcium channel blockers, they are known to be effective in the conditions, angina, hypertension, myocardial infarction and show vasodilatory and cardiac depressant effects.
openaire   +1 more source

The effect of dissolution medium, rotation speed and compaction pressure on the intrinsic dissolution rate of amlodipine besylate, using the rotating disk method [PDF]

, 2014
The aim of this study was to evaluate the effect of dissolution medium, rotation speed and compaction pressure on the intrinsic dissolution rate (IDR) of the antihypertensive drug amlodipine besylate, using the rotating disk method.
Ferraz, Humberto Gomes, Giorgetti, Leandro, Issa, Michele Georges   +2 more
core   +4 more sources

Anticancer Activity of 4-Aryl-1,4-Dihydropyridines

Future Pharmacology
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human ...
Thaís A. S. Oliveira, Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, Antônio E. M. Crotti   +5 more
doaj   +1 more source

An efficient Hantzsch synthesis of 1,4-dihydropyridines using p-toluenesulfonic acid under solvent-free condition [PDF]

Maejo International Journal of Science and Technology, 2014
An efficient Hantzsch synthesis of various substituted 1,4-dihydropyridines from an aldehyde, a β-dicarbonyl compound and ammonium acetate using p-toluenesulfonic acid in a solvent-free condition in the absence of any other co ...
Masoud Nasr-Esfahani , Morteza Montazerozohori , Razieh Raeatikia   +2 more
doaj   +1 more source

Sol - Gel synthesis and characterization of magnesium peroxide nanoparticles [PDF]

, 2014
Magnesium peroxide is an excellent source of oxygen in agriculture applications, for instance it is used in waste management as a material for soil bioremediation to remove contaminants from polluted underground water, biological wastes treatment to ...
Chan, Yen
core   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source