Results 41 to 50 of about 85,474,312 (231)

Synthesis of 1,4-Dihydropyridines Bearing a Carbamate Moiety on the 4-Position

Journal of Chemistry, 2013
A good range of 1,4-dihydropyridines bearing a carbamate moiety on the 4-position were synthesized from the primary reaction of different hydroxyaldehydes with phenyl isocyanates and the subsequent reaction of the obtained carbamates with methyl ...
Davood Habibi, Mohammad Ali Zolfigol, Maliheh Safaee   +2 more
doaj   +1 more source

Recent Progresses in the Catalytic Stereoselective Dearomatization of Pyridines

Molecules, 2023
1,2- and 1,4-dihydropyridines and N-substituted 2-pyridones are very important structural motifs due to their synthetic versatility and vast presence in a variety of alkaloids and bioactive molecules.
Lucrezia Margherita Comparini, Mauro Pineschi   +1 more
doaj   +1 more source

EVALUATION OF HEMATOTOXICITY OF NEW DERIVATIVES OF CONDENSED 3-AMINOTHIENO[2,3-B]PYRIDINES AND 1,4-DIHYDROPYRIDINES WITH HIGH ANALGESIC ACTIVITY

Паёми Сино, 2023
Objective: To assess changes in blood parameters in rats after a two-week administration of the most commonly used clinically NSAIDs and new derivatives of the 3-aminothieno[2,3-b]pyridine and 1,4-dihydronicotinamide series with the most pronounced ...
I.V. BIBIK, A.A. PANKOV, K.A. FROLOV, V.V. DOTSENKO, S.G. KRIVOKOLYSKO, E.YU. BIBIK   +5 more
doaj   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

1, 4-Dihydropyridine Derivatives : Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress1, 4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Oxidative medicine and cellular longevity, 2016
Many 1, 4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA).
Žarković, Neven, Gall Trošelj, Koraljka   +1 more
openaire   +2 more sources

Gold‐Catalyzed Cyclization of Indole‐Tethered Alkynes Enabling Synthesis of Exocyclic Alkenyl Tetrahydrocarbazoles

European Journal of Organic Chemistry, EarlyView.
An efficient gold‐catalyzed intramolecular cyclization of indole‐tethered alkynes using AgNTf2 as an additive has been developed, which provides bioactive exocyclic alkenyl tetrahydrocarbazoles with up to 85% yield. Control experiments and DFT studies indicate that the reaction proceeds via a 6‐exo‐dig cyclization pathway, with gold acetylide complexes
Haibo Mei, Jingrui He, Chengting Wang, Jorge Escorihuela, Jianlin Han   +4 more
wiley   +1 more source

Oxidative aromatization of Hantzsch 1,4-dihydropyridines by sodium chlorite

, 2010
Hantzsch 1,4-dihydropyridines were converted to the corresponding pyridines efficiently by sodium chlorite under mild conditions in excellent yields. (C) 2010 Elsevier Ltd.
Lin, Wenbin, Liao, Xiali, Lu, Jun, Wang, C, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China, Wang, Chun, Chun Wang, Xiali Liao, Wenbin Lin, Jun Lu   +8 more
core   +1 more source

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines

Data in Brief, 2020
In this data file the synthetic procedures for preparation of the original 4-pyridinium-1,4-dihydropyridines (4-Py-1,4-DHP) and their parent compounds – dialkyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylates were described. In total, 5
Klavs Pajuste, Martins Rucins, Ilona Domracheva, Arkadij Sobolev, Nadiia Pikun, Mara Plotniece, Gunars Duburs, Karlis Pajuste, Aiva Plotniece   +8 more
doaj   +1 more source

Improving the Sensitivity in Chiral Analysis by Capillary Electrophoresis

ELECTROPHORESIS, EarlyView.
Most recent advances for the enhancement of sensitivity in capillary electrophoresis, including off‐line and in‐capillary preconcentration techniques and their combinations, and the use of alternative detection systems to UV–Vis spectrophotometric absorption.
María Castro‐Puyana, Sandra Salido‐Fortuna, María Luisa Marina   +2 more
wiley   +1 more source

Synthesis of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines as novel skin protecting and anti-aging agents

Bangladesh Journal of Pharmacology, 2017
A series of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyri-dines 6a-6h were prepared by using the one-pot three component synthetic method.
Aamer Saeed, Danish Shahzad, Fayaz Ali Larik, Pervaiz Ali Channar, Haroon Mahfooz, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo, Ghulam Shabir   +9 more
doaj   +1 more source