Results 51 to 60 of about 5,843 (268)

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines

Data in Brief, 2020
In this data file the synthetic procedures for preparation of the original 4-pyridinium-1,4-dihydropyridines (4-Py-1,4-DHP) and their parent compounds – dialkyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylates were described. In total, 5
Klavs Pajuste, Martins Rucins, Ilona Domracheva, Arkadij Sobolev, Nadiia Pikun, Mara Plotniece, Gunars Duburs, Karlis Pajuste, Aiva Plotniece   +8 more
doaj   +1 more source

Structure-reactivity correlation for the kinetics of the reaction of substituted 4-phenyl-1,4-dihydropyridines formation [PDF]

Journal of the Serbian Chemical Society, 2013
Quantitative structure-reactivity correlations for the kinetics of the Hantzsch's synthesis of substituted 4-phenyl-1,4-dihydropyridines in the reaction between ethyl m- and p-substituted benzylidene acetoacetate and enamine has been studied ...
Urošević Jovica V., Drmanić Saša Ž., Nikolić Jasmina B., Juranić Ivan O., Jovanović Bratislav Ž.   +4 more
doaj   +1 more source

A Systematic Review on 1, 4-Dihydropyridines and its Analogues: An Elite Scaffold

Biointerface Research in Applied Chemistry, 2021
1,4-Dihydropyridines are a group of pyridine-based molecules possessing a magnificent set of biological and therapeutic potentials. Belonging to the class of calcium channel blockers, they are known to be effective in the conditions, angina, hypertension, myocardial infarction and show vasodilatory and cardiac depressant effects.
openaire   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Spectroscopic and electrochemical study of interactions between DNA and different salts of 1,4-dihydropyridine AV-153 [PDF]

PeerJ, 2020
1,4-dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antimutagenic and DNA-binding activity. The latter activity was first described for water-soluble 1,4-DHP with carboxylic group in position 4, the ...
Elina Leonova, Karlis Shvirksts, Vitalijs Borisovs, Edgars Smelovs, Jelizaveta Sokolovska, Egils Bisenieks, Gunars Duburs, Mara Grube, Nikolajs Sjakste   +8 more
doaj   +2 more sources

Isothiourea-catalyzed enantioselective α-alkylation of esters via 1,6-conjugate addition to para-quinone methides [PDF]

, 2021
Funding: We thank the ERC under the European Union's Seventh Framework Programme (FP7/2007-2013)/E.R.C. grant agreement n° 279850, AstraZeneca and EPSRC [EP/M506631/1 (J.N.A.)], Syngenta and the EPSRC Centre for Doctoral Training in Critical Resource ...
Arokianathar, Jude N., Greenhalgh, Mark David, Hartley, Will, McLaughlin, Calum, Ng, Sean, Slawin, Alexandra Martha Zoya, Smith, Andrew David, Stead, Darren   +7 more
core   +3 more sources

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Synthesis of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines as novel skin protecting and anti-aging agents

Bangladesh Journal of Pharmacology, 2017
A series of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyri-dines 6a-6h were prepared by using the one-pot three component synthetic method.
Aamer Saeed, Danish Shahzad, Fayaz Ali Larik, Pervaiz Ali Channar, Haroon Mahfooz, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo, Ghulam Shabir   +9 more
doaj   +1 more source

Dearomatization with Axial‐to‐Central Chirality Conversion

European Journal of Organic Chemistry, EarlyView.
Atropisomers are exciting synthetic targets with unique properties, which find applications in many fields of chemistry. However, considering them as substrates is not very frequent, notably in the context of dearomatization reaction. We wish to discuss the different strategies for the dearomatization of aromatic atropisomers with axial‐to‐central ...
Morgane Mando, Clément Lemaitre, Thierry Constantieux, Xavier Bugaut   +3 more
wiley   +1 more source

Synthesis and biological evaluation of 1,2,4-triazoles and 1,3,4-oxadiazoles derivatives linked to 1,4-dihydropyridines scaffold

Acta Chimica Slovenica, 2017
A series of diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivative coupled to 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones moieties at C2,C6 positions of 1,4-dihydropyridine ring system was prepared.
Maghsoud Ziaie, Karim Akbaridilmaghani, Amir Tukmechi   +2 more
doaj   +1 more source