Results 51 to 60 of about 85,474,312 (231)

Structure-reactivity correlation for the kinetics of the reaction of substituted 4-phenyl-1,4-dihydropyridines formation [PDF]

Journal of the Serbian Chemical Society, 2013
Quantitative structure-reactivity correlations for the kinetics of the Hantzsch's synthesis of substituted 4-phenyl-1,4-dihydropyridines in the reaction between ethyl m- and p-substituted benzylidene acetoacetate and enamine has been studied ...
Urošević Jovica V., Drmanić Saša Ž., Nikolić Jasmina B., Juranić Ivan O., Jovanović Bratislav Ž.   +4 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Synthesis and biological evaluation of 1,2,4-triazoles and 1,3,4-oxadiazoles derivatives linked to 1,4-dihydropyridines scaffold

Acta Chimica Slovenica, 2017
A series of diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivative coupled to 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones moieties at C2,C6 positions of 1,4-dihydropyridine ring system was prepared.
Maghsoud Ziaie, Karim Akbaridilmaghani, Amir Tukmechi   +2 more
doaj   +1 more source

Synthesis of 1, 4-dihydropyridines (DHP) Catalyzed by Trichloroisocyanuric Acid (TCCA) in Aqueous Media [PDF]

Scientia Iranica, 2016
An array of 1, 4-dihydropyridines (DHP) derivativeswas synthesized by Hantzsch three-component reaction of aromatic aldehydes, ethyl acetoacetate and ammonium acetate using trichloroisocyanuric acid (TCCA) as an efficient catalyst in aqueous media. The proposed method was operationally simple and to make the process benign for the environment, water ...
Marziyeh Roknaddini, Enayatollah sheikhhosseiny   +1 more
openaire   +1 more source

Palladium‐Catalyzed Heck‐Type Double Arylation of 1,2‐Dihydropyridines

Helvetica Chimica Acta, EarlyView.
A Pd‐catalyzed Heck‐type double arylation of 1,2‐dihydropyridines enables concise access to 2‐substituted 3,6‐diarylated scaffolds with high site‐ and regioselectivity. ABSTRACT We report a site‐ and regioselective Heck‐type double arylation of substituted 1,2‐dihydropyridines.
Haining Li, Zackaria Nairoukh
wiley   +1 more source

Alkylation Reactions of Azodicarboxylate Esters with 4‑Alkyl-1,4-Dihydropyridines under Catalyst-Free Conditions

, 2019
Introduction of alkyl groups on azodicarboxylate esters is an important method to prepare alkyl amine derivatives. Herein, we report reactions of 4-alkyl-1,4-dihydropyridines as alkylation reagents with di-tert-butyl azodicarboxylate to prepare alkyl ...
Yulin Zhang (510822), Kazunari Nakajima (1606096), Yoshiaki Nishibayashi (1606090)   +2 more
core   +1 more source

One-Pot Synthesis of 1, 4-Dihydropyridines in PEG Under Catalyst-Free Conditions [PDF]

Advances in Engineering Research, 2015
A simple, inexpensive, and efficient one-pot synthesis of 1,4-dihydropyridine via Hantzsch reaction was achieved in good to excellent yields under catalyst free conditions by using PEG400 as solvent. In this reaction, PEG-400 was used as the solvent, which has such advantages: absolutely nontoxic, inexpensive, thermally stable, recoverable and easy to ...
Shuwei Zhang, Ying Zhang, Lu Cao, Xiangfeng Kong, Liang Jun, Jing Lv   +5 more
openaire   +1 more source

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source

Synthesis of new 4-nitrosophenyl-1,4-dihydropyridines of pharmacological interest [PDF]

, 2003
The synthesis and characterization of a series of 4-nitrosophenyl-1.4-dihydropyridines derived from the respective nitro compounds of pharmacological interest is described.
Squella Serrano, Juan, Núñez Vergara, Luis, Santander Gutiérrez, Ingrid Paola, Navarrete Encina, Patricio   +3 more
core  

Regio and enantioselective synthesis of 4-carbomethoxymethyl-1,4 dihydropyridines

, 1994
Regio and enantioselective 1,4 addition of ethoxyvinyl copper reagent on a pyridine bearing in position 3 a chiral aminal is described.
Raussou, Sabine, Alexakis, Alexandre, Sabine Raussou, Alexandre Alexakis, Gosmini, Romain, Romain Gosmini, Pierre Mangeney, Mangeney, Pierre, Monique Commerçon, Commerçon, Monique   +9 more
core   +1 more source