Results 11 to 20 of about 85,474,312 (231)
SYNTHESIS OF 4-(1-BENZYL-5-IMIDAZOLYL)-1,4-DIHYDROPYRIDINES [PDF]
Journal of Sciences, Islamic Republic of Iran, 2002 The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was ...
doaj +2 more sources
Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity. [PDF]
Sci Rep, 2017 AbstractThe present study, we design and synthesize the novel dihydropyridine derivatives, i.e., 3 (a-e) and 5 (a-e) and evaluated, anticonvulsant activity. Initially due to the lacuna of LCC, we modeled the protein through modeller 9.15v and evaluated through servers.
Saddala MS +4 more
europepmc +7 more sources
REACTIONS OF DIHYDROPYRIDINES WITH BENZYNE [PDF]
Journal of Sciences, Islamic Republic of Iran, 1998 Reactions of 1 ,Zdihydropyridines (la-c) and 1,4-dihydropyridines (2a-c) in the presence of benzyne (3) under thermal conditions, and in the case of (2c) under photochemical conditions, have been investigated.
doaj +1 more source
A Facile Transformation of Amino acids into 1,4-dihydropyridines and their Crystallographic Analysis [PDF]
, 2021 A facile transformation of amino acids into substituted 1,4-dihydropyridines (1,4-DHP) is reported. The natural amino acids were converted into gamma-amino beta-keto esters and used for the synthesis of substituted 1,4-dihydropyridines from the ...
Anindita, Adak, Puneeth , Koppal
core +2 more sources
, 2022 We report a metal-free trifluoromethylthiolation and trifluoromethylselenolation of 1,4-dihydropyridines with S-(trifluoromethyl) 4-methylbenzenesulfonothioate and Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate under visible light irradiation. This
Enxue Chen (14303621) +11 more
core +1 more source
Transition-Metal-Free Alkylation and Acylation of Benzoxazinones with 1,4-Dihydropyridines
, 2021 The direct functionalization of N-heterocycles is a vital transformation for the development of pharmaceuticals, functional materials, and other chemical entities.
Prithwish Ghosh (7122755) +13 more
core +2 more sources
Cobalt-Catalyzed Selective Dearomatization of Pyridines to N–H 1,4-Dihydropyridines
, 2022 Catalytic reduction of pyridines to N–H 1,4-dihydropyridines is exceptionally challenging because they are essential intermediates to form tetrahydropyridines.
Lan Liu (88052) +15 more
core +1 more source
Direct photolysis of 4-tert-alkyl-1,4-dihydropyridines under blue-light irradiation for the generation of tertiary alkyl radicals [PDF]
, 2022 Herein, we disclose a direct photolysis approach for the generation of tertiary alkyl radicals from 4-tert-alkyl-1,4-dihydropyridines (DHPs) under blue LED irradiation, as exemplified in a photochemical Giese reaction.
Spencer, Pitre, Prasadi, Gallage
core +2 more sources
PHOTODEGRADATION OF 1, 4-DIHYDROPYRIDINE ANTIHYPERTENSIVE DRUGS: AN UPDATED REVIEW
International Journal of Pharmacy and Pharmaceutical Sciences, 2018 1, 4-dihydropyridine calcium channels blockers (DHPs) are the most commonly used antihypertensive drugs. Unfortunately, these compounds have a significant degradability to light. The oxidation to the pyridine derivative represents the first, and in many cases the only, step of the degradation mechanism.
MICHELE DE LUCA +3 more
openaire +4 more sources
, 2020 In this study, a facile and efficient method to synthesize monofluoroalkenes by photoredox catalytic defluorinative alkylation of gem-difluoroalkenes with 4-alkyl-1,4-dihydropyridines under mild conditions (room temperature) is described.
Jing Sun (141206) +6 more
core +1 more source