Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity. [PDF]
Sci Rep, 2017 AbstractThe present study, we design and synthesize the novel dihydropyridine derivatives, i.e., 3 (a-e) and 5 (a-e) and evaluated, anticonvulsant activity. Initially due to the lacuna of LCC, we modeled the protein through modeller 9.15v and evaluated through servers.
Saddala MS +4 more
europepmc +7 more sources
Investigation of Catalytic Activity of Pillared-layer Ni (II) Metal-Organic Framework Derived NiO Nanoparticles for Aromatization of Hantzsch 1,4-Dihydropyridines [PDF]
Journal of Sciences, Islamic Republic of Iran, 2020 The pillared-layer metal-organic framework of Ni2(BTEC)(bipy)3.3DMF.2H2O (BTEC = 1,2,4,5-benzenetetracarboxylate; bipy = 4,4́-bipydine; DMF =N,Ń-dimethylformamide) was prepared, characterized and used as a precursor for preparation of NiO nanoparticles.
Zeinab Asgharpour, Faezeh Farzaneh
doaj +3 more sources
The single Fe atoms and DDQ catalyst system for the aerobic dehydrogenation of dihydropyridines and dihydroquinazolinones [PDF]
Scientific ReportsSingle-atom nanozymes (SAzymes) made of iron show great potential as artificial enzymes due to their consistent active sites closely resembling the active centers found in natural enzymes. They can be produced from accessible and affordable raw materials,
Hamzeh Veisi, Amin Rostami
doaj +2 more sources
SYNTHESIS AND PRELIMINARY ALKYLATING ACTIVITIES OF CERTAIN NEW 1,4-DIHYDROPYRIDINES, PYRIDINIUM SALTS AND 2,7-DIAZABICYCLO [4.1.0] HEPT-3-ENES [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 1993 3-Substituted-1-{2-chloro- or [2-bis (2-chloroethyl)amino]}ethyl-1,4-dihydropyridines 3 and 6 were prepared by reduction of the corresponding pyridinium chlorides 2 and 5 with sodium dithionite in alkaline medium.
Nawal El-Koussi +3 more
doaj +1 more source
Data in Brief, 2020 This data file describes the synthetic protocol for preparation of the original 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines. In total, 6 unpublished compounds were obtained and characterised.
Martins Rucins +6 more
doaj +1 more source
Results in Chemistry, 2023 Derivatives of dihydropyridines are promising agents for research, as they have high biological activity. Their low toxicity and polytargeted properties make it possible to create new derivatives and identify new biological activity. As part of this work,
Arkadiy Bryzgalov +3 more
doaj +1 more source
Intramolecular hydrogen bonds in 1,4-dihydropyridine derivatives [PDF]
Royal Society Open Science, 2018 1,4-Dihydropyridine (1,4-DHP) derivatives have been synthesized and characterized by 1H, 13C, 15N nuclear magnetic resonance (NMR) spectroscopy, secondary proton/deuterium 13C isotope shifts, variable temperature 1H NMR experiments and quantum-chemical ...
M. Petrova +4 more
doaj +1 more source
MODULATION OF CALCIUM CHANNELS IN ARTERIAL SMOOTH-MUSCLE CELLS BY DIHYDROPYRIDINE ENANTIOMERS [PDF]
, 1993 The actions of the optical enantiomers of BAY K 8644 and Sandoz 202,791 were studied on barium inward currents recorded using the whole-cell configuration of the patch clamp technique from enzymatically isolated smooth muscle cells from the rabbit ear ...
Bolton, TB +3 more
core +1 more source
Carbon Resources Conversion, 2019 A novel Acetazolamide condensed 1, 4-dihydropyridines was set up by treating of N-(5-acetamido-1, 3, 4-thiadiazol-2-ylsulfonyl)-3-oxobutanamide with an aryl aldehyde and 25–30% alkali with sight amount of barium nitrate as a catalyst. Confirmation of the
Mudduluru Niranjan Babu +5 more
doaj +1 more source
QSAR study of HCV NS5B polymerase inhibitors using the genetic algorithm-multiple linear regression (GA-MLR) [PDF]
, 2016 Quantitative structure–activity relationship (QSAR) study has been employed for predicting the inhibitory activities of the Hepatitis C virus (HCV) NS5B polymerase inhibitors. A data set consisted of 72 compounds was selected, and then different types of
Aalizadeh, Reza +6 more
core +1 more source