Results 121 to 130 of about 2,273 (170)

Alternate substrates and inhibitors of bacterial 4-hydroxyphenylpyruvate dioxygenase

Biochemistry, 1985
A variety of analogues of (4-hydroxyphenyl)pyruvic acid were synthesized, and the reactions of these compounds with the 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. P.J. 874 were examined. Several of the ring-substituted substrate analogues are reversible inhibitors of the enzyme, the most potent being the competitive inhibitor (2,6 ...
R A, Pascal, M A, Oliver, Y C, Chen
openaire   +2 more sources

Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase

Archives of Biochemistry and Biophysics, 1982
Abstract The purification of hog liver 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27), and the determination of some of its characteristics, are reported. The enzyme was purified 330-fold in 22% yield from an acetone powder extract by ammonium sulfate fractionation, chromatography twice using sulfopropyl Sephadex under carefully controlled pH ...
P A, Roche, T J, Moorehead, G A, Hamilton   +2 more
openaire   +2 more sources

4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target

Drug News & Perspectives, 2003
The molecular mechanism for 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibition by nitisinone, a recently approved new drug for the treatment of hereditary tyrosinemia type I, has been satisfactorily explained by its action as an analogue to the substrate 4-hydroxyphenylpyruvate.
openaire   +2 more sources

Discovery of novel benzofuran scaffold as 4‐hydroxyphenylpyruvate dioxygenase inhibitors

Pest Management Science, 2020
AbstractBACKGROUND4‐Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. This study sheds new light on the differences in molecular scaffold from commercialized HPPD inhibitors.RESULTSThe compounds A1‐A18 and B1‐B27 were synthesized for in vitro and greenhouse experiments. The greenhouse
Hao Huang, Jian‐qiu Zhang, Jian‐min Liu, Man‐man Wang, Lei Shu, Yi‐le Yan, Xiao‐hang Zhan, Ping Wang, Xue‐ting Huan, Da‐yong Zhang   +9 more
openaire   +2 more sources

Identification of a novel 4-hydroxyphenylpyruvate dioxygenase from the soil metagenome

Biochemical and Biophysical Research Communications, 2008
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a Fe(II)-dependent, non-heme oxygenase that converts 4-hydroxyphenylpyruvate to homogentisate. Essential cofactors, such as plastoquinone and tocopherol, are produced by HPPD-dependent anabolic pathways in plants.
Chang-Muk, Lee, Yun-Soo, Yeo, Jung-Han, Lee, Soo-Jin, Kim, Jung-Bong, Kim, Nam Soo, Han, Bon-Sung, Koo, Sang-Hong, Yoon   +7 more
openaire   +2 more sources

Improving the herbicide resistance of 4-hydroxyphenylpyruvate dioxygenase SpHPPD by directed evolution

Enzyme and Microbial Technology, 2022
Topramezone, a highly efficient 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibitor herbicide, is an ideal target for herbicide-resistant genetic engineering. However, there is still a lack of HPPD gene that is highly resistant to topramezone. In previous studies, we obtained a topramezone-resistant HPPD (SpHPPDm) gene from Sphingobium sp.
Haiyan, Wang, Bin, Liu, Peng, Lei, Jianchun, Zhu, Le, Chen, Qin, He, Jian, He   +6 more
openaire   +2 more sources

Cypyrafluone, a 4-Hydroxyphenylpyruvate Dioxygenase Inhibitor to Control Weed in Wheat Fields

Journal of Agricultural and Food Chemistry, 2023
As a bleaching herbicide, cypyrafluone was applied postemergence in wheat fields for annual weed control; especially, this herbicide possesses high efficacy against cool-season grass weed species such as Alopecurus aequalis and Alopecurus japonicus.
Lei Lian, Hengzhi Wang, Fengwen Zhang, Weitang Liu, Xingtao Lu, Tao Jin, Jinxin Wang, Xiuhai Gan, Baoan Song   +8 more
openaire   +2 more sources

Design and Syntheses of Proherbicides Targeting 4-Hydroxyphenylpyruvate Dioxygenase

Journal of Agricultural and Food Chemistry
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is regarded as a crucial target in the domain of herbicide discovery. Herein, we adopted the proherbicides concept, based on the initially discovered lead compound II-aa. Our group has designed four derivatives by incorporating alkyl, carbonyl ester, sulfonyl ester, and phosphate ester fragments.
Bo He, Li-jun Chen, Yi-xuan Fu, Tian-zhu Zhang, Feng-xu Wu, Jin Dong, Liang-Kun Yu, Xian-Quan Wang, Hong-Yan Lin, Guang-Fu Yang   +9 more
openaire   +2 more sources

4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Chemical Biology to Agrochemicals

Journal of Agricultural and Food Chemistry, 2017
The development of new herbicides is receiving considerable attention to control weed biotypes resistant to current herbicides. Consequently, new enzymes are always desired as targets for herbicide discovery. 4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an enzyme engaged in photosynthetic activity and catalyzes the transformation of 4 ...
Ferdinand Ndikuryayo, Behrooz Moosavi, Wen-Chao Yang, Guang-Fu Yang   +3 more
openaire   +2 more sources

Mechanism and Mechanism-Based Inactivation of 4-Hydroxyphenylpyruvate Dioxygenase

Bioorganic Chemistry, 1994
Abstract Six substrate analogs of 4-hydroxyphenylpyruvate, specifically pentafluorophenylpyruvate, 4-hydroxytetrafluorophenylpyruvate,2-thienylpyruvate, 3-thienylpyruvate, thiophenol oxalate, and p -thiocresoloxalate were synthesized and their interactions with porcine liver 4-hydroxyphenylpyruvate dioxygenase investigated.
B.J.R. Forbes, G.A. Gordon
openaire   +1 more source