Results 101 to 110 of about 12,760,006 (203)

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes

FEBS Open Bio, 2019
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed.
José Mário F. Balanco, Rodrigo A.C. Sussmann, Ignasi B. Verdaguer, Heloisa B. Gabriel, Emilia A. Kimura, Alejandro M. Katzin   +5 more
doaj   +1 more source

Computer-Aided and AILDE Approaches to Design Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. [PDF]

Int J Mol Sci, 2022
Shi J, Gao S, Wang JY, Ye T, Yue ML, Fu Y, Ye F.   +6 more
europepmc   +1 more source

Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation. [PDF]

Arch Toxicol, 2023
Botham J, Lewis RW, Travis KZ, Baze A, Richert L, Codrea E, Semino Beninel G, Garcin JC, Strupp C.   +8 more
europepmc   +1 more source

A theoretical study of the inhibition of human 4-hydroxyphenylpyruvate dioxygenase by a series of pyrazalone-quinazolone hybrids [PDF]

, 2016
A Density Functional Theory study was carried out to find relationships between the electronic/molecular structure of a group of pyrazalone-quinazolone hybrids and their inhibition of human 4-hydroxyphenylpyruvate dioxygenase (HPPD).
Gómez Jeria, Juan, Moreno-Rojas, Camila
core  

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science
4‐hydroxyphenylpyruvate dioxygenase (HPD) is an important metabolic enzyme in the tyrosine metabolic pathway and displays aberrant expression and function in cancer.
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
doaj   +1 more source

Resistance to a nonselective 4-hydroxyphenylpyruvate dioxygenase-inhibiting herbicide via novel reduction-dehydration-glutathione conjugation in Amaranthus tuberculatus. [PDF]

New Phytol, 2021
Concepcion JCT, Kaundun SS, Morris JA, Hutchings SJ, Strom SA, Lygin AV, Riechers DE.   +6 more
europepmc   +1 more source

The Role of 4-Hydroxyphenylpyruvate Dioxygenase in Enhancement of Solid-Phase Electron Transfer by Shewanella Oneidensis MR-1 [PDF]

, 2007
While mechanistic details of dissimilatory metal reduction are far from being understood, it is postulated that the electron transfer to solid metal oxides is mediated by outer membrane-associated c-type cytochromes and redox active electron shuttling ...
Amy Ekechukwu, A, Turick, C
core  

Discovery of Triketone-Quinazolinone Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is a promising target for new herbicide research. To develop new HPPD-inhibiting herbicides, we used a scaffold-hopping strategy by introducing a quinazolinone ring and combining it with the ...
Hong-Yan Lin, Yu-Jun Dong, Wan-Jie Zhang, Jing Zhao, Shao-Meng Zhou, Da-Wei Wang, Zhuo-Mei Cai, Rui-Ning Ying   +7 more
core   +1 more source

Isolation and Characterization of a Topramezone-Resistant 4‑Hydroxyphenylpyruvate Dioxygenase from Sphingobium sp. TPM-19

, 2019
Topramezone is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor. Due to its broad-spectrum, high efficiency, and low toxicity, topramezone is a candidate herbicide for the construction of genetically modified (GM) herbicide-resistant crops.
Bin Liu (5899), Haiyan Ni (2011666), Mengyao Sheng (6185246), Xiang Xiao (44417), Jian He (35118), Qing Tao (651802), Qian Peng (74762), Qin He (499660)   +7 more
core   +1 more source

Virtual Screening and Bioassay of Novel Protoporphyrinogen Oxidase and p-Hydroxyphenylpyruvate Dioxygenase Dual-Target Inhibitors

Molecules
Novel herbicide development is a challenge for weed control. Protoporphyrinogen oxidase (PPO) and p-hydroxyphenylpyruvate dioxygenase (HPPD) are two key enzymes involved in plant photosynthesis.
Panxiu Zhang, Haifeng Cao, Tiansong Li, Ying Fu   +3 more
doaj   +1 more source