Results 81 to 90 of about 2,253 (135)

Combining multiplex metabolic engineering with adaptive evolution strategies for high-level succinic acid production in <i>Yarrowia lipolytica</i>. [PDF]

Synth Syst Biotechnol
Sun T, Sun ML, Lin L, Gao J, Ledesma-Amaro R, Wang K, Ji XJ.   +6 more
europepmc   +1 more source

4-Hydroxyphenylpyruvate dioxygenase : primary structure and genomic characterization

, 2008
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4-Hydroxyphenylpyruvate Dioxygenase

Archives of Biochemistry and Biophysics, 2005
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an Fe(II)-dependent, non-heme oxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. This reaction involves decarboxylation, substituent migration and aromatic oxygenation in a single catalytic cycle.
Graham R Moran
exaly   +3 more sources

On 4-hydroxyphenylpyruvate dioxygenase of adult frog liver

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1982
1. It has been reported that 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) activity in the liver from Rana esculenta is present only after autolysis of trypsin digestion, which releases a heat-and acid-stable inhibitor of low molecular mass. 2. Attempts to demonstrate similar effects with the liver enzyme from adult Rana pipiens were unsuccessful.
S, Lindstedt, B, Odelhög, M, Rundgren
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Novel Pyrazole Amides as Potential 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

Journal of Agricultural and Food Chemistry, 2022
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for the development of new herbicides. HPPD inhibitors can hinder photosynthesis and induce weed death with bleaching symptoms. To explore the novel skeleton of HPPD inhibitors, a series of novel pyrazole amide derivatives were synthesized and evaluated for their inhibitory effects on ...
Huanan Zeng, Wei Zhang, Zhengxing Wang, Wang Geng, Gang Feng, Xiuhai Gan   +5 more
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Human 4‐hydroxyphenylpyruvate dioxygenase

European Journal of Biochemistry, 1993
We report the primary structure of 4‐hydroxyphenylpyruvate dioxygenase [4‐hydroxyphenylpyruvate: oxygen oxidoreductase (hydroxylating, decarboxylating)]. The work is based on the isolation of cDNA clones from human liver λgt11 libraries. Several overlapping clones covering the coding sequence were characterized.
U, Rüetschi, A, Dellsén, P, Sahlin, G, Stenman, L, Rymo, S, Lindstedt   +5 more
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Alternate substrates and inhibitors of bacterial 4-hydroxyphenylpyruvate dioxygenase

Biochemistry, 1985
A variety of analogues of (4-hydroxyphenyl)pyruvic acid were synthesized, and the reactions of these compounds with the 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. P.J. 874 were examined. Several of the ring-substituted substrate analogues are reversible inhibitors of the enzyme, the most potent being the competitive inhibitor (2,6 ...
R A, Pascal, M A, Oliver, Y C, Chen
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Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase

Archives of Biochemistry and Biophysics, 1982
Abstract The purification of hog liver 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27), and the determination of some of its characteristics, are reported. The enzyme was purified 330-fold in 22% yield from an acetone powder extract by ammonium sulfate fractionation, chromatography twice using sulfopropyl Sephadex under carefully controlled pH ...
P A, Roche, T J, Moorehead, G A, Hamilton   +2 more
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4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target

Drug News & Perspectives, 2003
The molecular mechanism for 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibition by nitisinone, a recently approved new drug for the treatment of hereditary tyrosinemia type I, has been satisfactorily explained by its action as an analogue to the substrate 4-hydroxyphenylpyruvate.
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Discovery of novel benzofuran scaffold as 4‐hydroxyphenylpyruvate dioxygenase inhibitors

Pest Management Science, 2020
AbstractBACKGROUND4‐Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. This study sheds new light on the differences in molecular scaffold from commercialized HPPD inhibitors.RESULTSThe compounds A1‐A18 and B1‐B27 were synthesized for in vitro and greenhouse experiments. The greenhouse
Hao Huang, Jian‐qiu Zhang, Jian‐min Liu, Man‐man Wang, Lei Shu, Yi‐le Yan, Xiao‐hang Zhan, Ping Wang, Xue‐ting Huan, Da‐yong Zhang   +9 more
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