Results 61 to 70 of about 2,273 (170)

Structure of the Human 4-Hydroxyphenylpyruvic Acid Dioxygenase Gene (HPD)

Genomics, 1994
4-Hydroxyphenylpyruvic acid dioxygenase (HPD) is an important enzyme in tyrosine catabolism in most organisms. The activity of this enzyme is expressed mainly in the liver and developmentally regulated in mammals, and a genetic deficiency in this enzyme in humans and mice leads to hereditary tyrosinemia type 3.
H, Awata, F, Endo, I, Matsuda
openaire   +2 more sources

Herbicide toxicity to Nitrospirillum amazonense: assessing bacterial survival and microbial functionality

Pest Management Science, Volume 82, Issue 2, Page 1842-1852, February 2026.
Herbicides elicit a spectrum of responses in Nitrospirillum amazonense, ranging from the stimulation of metabolic functions (biological nitrogen fixation, IAA production) to significant growth inhibition and acute toxicity. Abstract BACKGROUND Herbicides can exert significant toxicity on nontarget organisms, including plant growth‐promoting bacteria ...
Luana Carolina Gomes Jonck, Patrícia Andrea Monquero, Márcia Maria Rosa Magri, Carina de Fátima Felippe   +3 more
wiley   +1 more source

Molecular and Evolution In Silico Studies Unlock the h4-HPPD C-Terminal Tail Gating Mechanism

Biomedicines
The enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) is involved in the catabolism of the amino acid tyrosine in organisms such as bacteria, plants, and animals.
Alfonso Trezza, Ancuta Birgauan, Michela Geminiani, Anna Visibelli, Annalisa Santucci   +4 more
doaj   +1 more source

Therapeutic Monitoring of Patients With Hereditary Tyrosinemia Type 1—A Belgian Monocentric Experience

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Hereditary tyrosinemia type I (HT‐1) is a rare metabolic disorder treated by NTBC, requiring careful therapeutic and nutritional monitoring. While follow‐up traditionally relies on urinary succinylacetone, plasma NTBC and plasma amino acids, dried blood spot (DBS) methods have introduced alternative monitoring options.
Anne‐Sophie Adam, Lionel Marcélis, David Fage, Elise Mathieu, Aurélie Empain, Céline Dufour, Frédéric Cotton, Corinne de Laet   +7 more
wiley   +1 more source

Vitiligo, alkaptonuria, and nitisinone—A report of three families and review of the literature

JIMD Reports, 2021
Four patients, from three families, with alkaptonuria receiving 4‐hydroxyphenylpyruvate dioxygenase‐inhibiting nitisinone therapy, which lowers homogentisic acid and increases tyrosine, developed vitiligo.
Lakshminarayan Ranganath, Milad Khedr, Leanne A. Evans, Helen Bygott, Emily Luangrath, Elizabeth West   +5 more
doaj   +1 more source

Assessment of genetically modified soybean GMB151 × DAS‐44406‐6 (application GMFF‐2024‐21774, EFSA‐Q‐2024‐00330)

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract Genetically modified soybean GMB151 × DAS‐44406‐6 was developed by crossing to combine two single events: GMB151 and DAS‐44406‐6. The two‐event stack soybean expresses the Cry14Ab‐1, HPPD‐4, PAT, AAD‐12 and 2mEPSPS proteins to confer herbicide tolerance and resistance to plant parasitic nematodes.
EFSA Panel on Genetically Modified Organisms (GMO), Josep Casacuberta, Francisco Barro, Albert Braeuning, Ruud de Maagd, Michelle M. Epstein, Thomas Frenzel, Jean‐Luc Gallois, Frits Koning, Antoine Messéan, F. Javier Moreno, Fabien Nogué, Giovanni Savoini, Alan H. Schulman, Christoph Tebbe, Eve Veromann, Michele Ardizzone, Giacomo De Sanctis, Antonio Fernandez Dumont, Arianna Ferrari, Andrea Gennaro, José Ángel Gómez Ruiz, Tilemachos Goumperis, Sara Jacchia, Dafni Maria Kagkli, Paolo Lenzi, Ana M. Camargo, Franco Maria Neri, Tommaso Raffaello   +28 more
wiley   +1 more source

A Case of Tyrosinemia Type III with Status Epilepticus and Mental Retardation

Advanced Biomedical Research, 2018
Tyrosinemia type III is an autosomal recessive disorder caused by the deficiency of 4- hydroxyphenylpyruvate dioxygenase (4-HPPD). It is characterized by elevated levels of blood tyrosine and massive excretion of its derivatives into the urine.
Reza Najafi, Neda Mostofizadeh, Mahin Hashemipour   +2 more
doaj   +1 more source

Multifaceted Study of Medicago marina Essential Oil: Chemical Composition, Antidiabetic, and Phytotoxic Insights via In Vitro and In Silico Approaches

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT The essential oil of Medicago marina was subjected to analysis at vegetative and reproductive stages of development, with a particular emphasis on its chemical composition, α‐amylase inhibition, and allelopathic activities. The results of the gas chromatography and molecular docking studies demonstrated alterations in oil yield and composition
Marwa Melliti, Assia Hamdi, Mabrouk Horchani, Eliza de Jesus Barros dos Santos, Hichem Ben Jannet, Mohammad Faisal, Abdulrahman A. Alatar, Marcello Iriti, Mozaniel Santana de Oliveirae, Hayet Edziri   +9 more
wiley   +1 more source

Linking herbicide cross‐tolerance to agronomic and seed vigor traits: A multi‐trait genome‐wide association study in snap bean (Phaseolus vulgaris L.)

Crop Science, Volume 65, Issue 6, November/December 2025.
Abstract In snap bean (Phaseolus vulgaris L.) production, herbicides are essential for weed control, requiring crop tolerance to avoid injury. The study aimed to link genomic loci to agronomic traits, explore the extent of herbicide cross‐tolerance, and identify loci influencing seed vigor and herbicide tolerance traits. A panel was evaluated for seven
Ana Saballos, Martin M. Williams II
wiley   +1 more source

Tautomerism, Conformational Analysis, and Intramolecular Interactions in Triketone–Chalcogenazole Hybrids

Journal of Physical Organic Chemistry, Volume 38, Issue 11, November 2025.
Triketone herbicides inhibit HPPD via induced fit influenced by noncovalent interactions. Using DFT‐B3LYP and NBO analysis, this study examined hydrogen and chalcogen bonds in tautomer stabilization. Results showed enolic forms with stronger intramolecular interactions, while heavier atoms like sulfur and selenium uniquely facilitated chalcogen bonds ...
Luiz dos Reis Capucho, Elaine F. F. da Cunha, Matheus P. Freitas   +2 more
wiley   +1 more source