Results 61 to 70 of about 12,760,006 (203)

Transcriptomic analysis of wheat reveals possible resistance mechanism mediated by Yr10 to stripe rust

open access: yesStress Biology, 2023
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a catastrophic disease that threatens global wheat yield. Yr10 is a race-specific all-stage disease resistance gene in wheat.
Zhongyi Wu   +8 more
doaj   +1 more source

Assessment of genetically modified soybean FG72 for renewal authorisation under Regulation (EC) No 1829/2003 (dossier GMFF‐2025‐33580)

open access: yesEFSA Journal, Volume 24, Issue 7, July 2026.
Abstract Following the submission of dossier GMFF‐2025‐33580 under Regulation (EC) No 1829/2003 from Syngenta Crop Protection AG, the Panel on Genetically Modified Organisms of the EFSA was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the herbicide‐tolerant ...
EFSA Panel on Genetically Modified Organisms (GMO)   +19 more
wiley   +1 more source

Differential expression of 4-hydroxyphenylpyruvate dioxygenase-like in human epithelial ovarian cancer.

open access: yes, 2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to ...
Shahan Mamoor
core   +1 more source

Disruption of hmgA by DNA Duplication is Responsible for Hyperpigmentation in a Vibrio anguillarum Strain

open access: yesScientific Reports, 2019
Vibrio anguillarum 531A, isolated from a diseased fish in the Atlantic Ocean, is a mixture composed of about 95 and 5% of highly pigmented cells (strain 531Ad) and cells with normal levels of pigmentation (strain 531Ac), respectively.
Veronica Batallones   +18 more
doaj   +1 more source

Assessment of genetically modified soybean DAS‐44406 × FG72 (dossier GMFF‐2025‐34192)

open access: yesEFSA Journal, Volume 24, Issue 7, July 2026.
Abstract Genetically modified soybean DAS‐44406‐6 × FG72 was developed by conventional crossing to combine two single events: DAS‐44406‐6 and FG72. The soybean DAS‐44406‐6 × FG72 expresses the AAD‐12, 2mEPSPS, PAT and HPPD W336 proteins to confer herbicide tolerance to 2,4‐D‐, glyphosate‐, glufosinate‐containing and HPPD‐inhibiting herbicide products ...
EFSA Panel on Genetically Modified Organisms (GMO)   +28 more
wiley   +1 more source

Role of substrate positioning in the catalytic reaction of 4-hydroxyphenylpyruvate dioxygenase : a QM/MM study

open access: yes, 2014
Ring hydroxylation and coupled rearrangement reactions catalyzed by 4-hydroxyphenylpyruvate dioxygenase were studied with the QM/MM method ONIOM(B3LYP:AMBER).
Wójcik-Augustyn, Anna   +12 more
core   +1 more source

Discovery of Subnanomolar Inhibitors of 4‑Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design

open access: yes, 2023
High-potency 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors are usually featured by time-dependent inhibition. However, the molecular mechanism underlying time-dependent inhibition by HPPD inhibitors has not been fully elucidated.
Wen-Chao Yang   +17 more
core   +1 more source

Reinforcement learning-based generative artificial intelligence for novel pesticide design

open access: yesJournal of Advanced Research
Introduction: Pesticides play a pivotal role in ensuring food security, and the development of green pesticides is an inevitable trend in global agricultural progress. Although deep learning-based generative models have revolutionized de novo drug design
Ruoqi Yang   +6 more
doaj   +1 more source

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis.

open access: yesPLoS Biology, 2021
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations.
Marcos Sterkel   +17 more
doaj   +1 more source

Hepatic‐Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi‐Omics Analysis of Tumors With Lymphovascular Invasion

open access: yesCancer Medicine, Volume 15, Issue 4, April 2026.
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Shugo Yajima   +12 more
wiley   +1 more source

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