Results 41 to 50 of about 12,760,006 (203)

Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer

Cell Reports, 2021
Summary: The liver plays central roles in coordinating different metabolic processes, such as the catabolism of amino acids. In this study, we identify a loss of tyrosine catabolism and a concomitant increase in serum tyrosine levels during liver cancer ...
Man Tong, Tin-Lok Wong, Hongzhi Zhao, Yuanyuan Zheng, Yu-Nong Xie, Cheuk-Hin Li, Lei Zhou, Noélia Che, Jing-Ping Yun, Kwan Man, Terence Kin-Wah Lee, Zongwei Cai, Stephanie Ma   +12 more
doaj   +1 more source

Evaluation of models for the mechanism of action of 4-hydroxyphenylpyruvate dioxygenase

Experientia, 1981
3-Hydroxyphenylpyruvic acid was oxygenated with various complexes of oxygen with Fe2+, superoxide ion, hydroperoxide anion, triplet and singlet oxygen. Oxidation occurred giving varying amounts of the 4-hydroxy derivatives of benzaldehyde, benzoic acid, phenol, phenylacetic acid and 4-carboxymethylquinone, but no homogentisic acid.
Jefford, Charles, Cadby, Peter Alan
openaire   +3 more sources

The interaction of hydroxymandelate synthase with the 4-hydroxyphenylpyruvate dioxygenase inhibitor: NTBC [PDF]

Inorganica Chimica Acta, 2008
Hydroxymandelate synthase (HMS) catalyzes the committed step in the formation of para-hydroxyphenylglycine, a recurrent substructure of polycyclic non-ribosomal peptide antibiotics such as vancomycin. HMS uses the same substrates as 4-hydroxyphenylpyruvate dioxygenase (HPPD), 4-hydroxyphenylpyruvate (HPP) and O(2), and also conducts a dioxygenation ...
John A, Conrad, Graham R, Moran
openaire   +2 more sources

Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition

, 2021
PURPOSE: Dioxygenases are oxidoreductase enzymes with roles in metabolic pathways necessary for aerobic life. 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by HPDL, is an orphan paralogue of 4-hydroxyphenylpyruvate dioxygenase (HPD ...
Ding, Jeffrey, Jain, Mohit, Waters, Elizabeth R, Toosi, Mehran Beiraghi, Pan, Daqiang, Verhoeven-Duif, Nanda M, Murphy, David, McEvoy-Venneri, Jennifer, Ghosh, Shereen G, Ben-Omran, Tawfeg, Ashrafzadeh, Farah, Chai, Guoliang, Karimiani, Ehsan Ghayoor, Maroofian, Reza, Sultan, Tipu, Imannezhad, Shima, Lübbert, Philipp, Patel, Aakash, Abdel-Salam, Ghada, Wiedemann, Nils, Alvi, Javeria Raza, Jans, Judith J, Gleeson, Joseph G, Ibrahim, Khalid, Kammerer, Bernd, Stanley, Valentina, Ross, Danica, Lee, Sangmoon, Zaki, Maha S, Fabunan, Rudy   +29 more
core  

HPPD gene expression in relation to vitamin E content in spring barley

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2009
The enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD) has a very important role in the biosynthetic pathway of vitamin E. Its activity influences the final level of tocols in plant tissues. Seven barley cultivars with different vitamin E level were grown
Michal Kosař, Lumila Holková, Natálie Březinová Belcredi, Jaroslava Ehrenbergerová   +3 more
doaj   +1 more source

Mode of Action of 4-Hydroxyphenylpyruvate Dioxygenase Inhibition by Triketone-type Inhibitors

, 2016
A series of 2-(2-nitrobenzoyl)cyclohexane-1,3-dione analogues (1−9) were designed, synthesized, and evaluated for inhibition of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD), a key enzyme involved in the catabolism of tyrosine which catalyzes the ...
Ding-Yah Yang (1434001), Yang-Sheng Sun (2262616), Chung-Shieh Wu (2724706), Jian-Lin Huang (1918393)   +3 more
core   +1 more source

Design, Synthesis, and Herbicidal Activity Evaluation of Novel Aryl-Naphthyl Methanone Derivatives

Frontiers in Chemistry, 2019
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is one of the most vital targets for herbicides discovery. In search for HPPD inhibitors with novel scaffolds, a series of aryl-naphthyl methanone derivatives have been designed and synthesized through ...
Ying Fu, Kui Wang, Peng Wang, Jing-Xin Kang, Shuang Gao, Li-Xia Zhao, Fei Ye   +6 more
doaj   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

Pest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti, Eric L. Patterson, Todd A. Gaines, Aldo Merotto   +3 more
wiley   +1 more source

Identifying resistance‐conferring cytochrome P450s in weeds: experimental strategies and practical considerations

Pest Management Science, EarlyView.
Identifying resistance‐conferring cytochrome P450s requires integrating weed characterization, gene discovery and functional validation. No single approach is sufficient to distinguish causal resistance genes from herbicide‐metabolizing enzymes. Abstract Cytochrome P450 monooxygenases (P450s) play a pivotal role in metabolic herbicide resistance, yet ...
Satoshi Iwakami, Takuya Yamaguchi
wiley   +1 more source

Elucidation of the 4-hydroxyacetophenone catabolic pathway in Pseudomonas fluorescens ACB [PDF]

, 2008
The catabolism of 4-hydroxyacetophenone in Pseudomonas fluorescens ACB is known to proceed through the intermediate formation of hydroquinone. Here we provide evidence that hydroquinone is further degraded through 4-hydroxymuconic semialdehyde and ...
Janssen, D.B., Westphal, Adrie H., Boeren, Sjef A., Janssen, Dick B., Moonen, Marielle J. H., Westphal, A.H., Fraaije, M.W., van Berkel, W.J.H., Boeren, J.A., Berkel, W.J.H., van, Kamerbeek, Nanne M., Moonen, M.J.H., Fraaije, Marco W., van Berkel, Willem J. H., Kamerbeek, N.M.   +14 more
core   +2 more sources