Results 31 to 40 of about 12,760,006 (203)

Hydroquinone dioxygenase from Pseudomonas fluorescens ACB: A novel member of the family of non-heme iron (II)-dependent dioxygenases [PDF]

, 2008
Hydroquinone 1,2-dioxygenase (HQDO), an enzyme involved in the catabolism of 4-hydroxyacetophenone in Pseudomonas fluorescens ACB, was purified to apparent homogeneity.
Westphal, Adrie H., R. H. H. van den Heuvel, van den Berg, Willy A. M., Heck, A.J.R., van den Berg, W.A.M., S. A. Synowsky, M. J. H. Moonen, A. H. Westphal, Westphal, A.H., Fraaije, M.W., Fraaije, Marco W., A. J. R. Heck, W. J. H. van Berkel, Berg, W.A.M., van den, Moonen, Marielle J. H., Synowsky, S.A., van Berkel, W.J.H., Berkel, W.J.H., van, Synowsky, Silvia A., van den Heuvel, R.H.H., Moonen, M.J.H., van den Heuvel, Robert H. H., van Berkel, Willem J. H., W. A. M. van den Berg, Heck, Albert J. R., Heuvel, R.H.H., van den, M. W. Fraaije   +26 more
core   +2 more sources

Vibrio splendidus virulence to Apostichopus japonicus is mediated by hppD through glutamate metabolism and flagellum assembly

Virulence, 2022
Vibrio splendidus is the main opportunistic pathogen that causes skin ulcer syndrome in Apostichopus japonicus. hppDIn the present study, mutant V. splendidus with an in-frame deletion of hppDV.s. (MTVs) was constructed.
Weikang Liang, Weiwei Zhang, Chenghua Li
doaj   +1 more source

In Silico Design and Validation of a Novel HPPD-Inhibiting Herbicide Candidate Based on Benzofuran and Arylthioacetic Acid Scaffolds. [PDF]

Chem Biodivers
A benzofuran‐triketone hybrid emerged as the most promising 4‐hydroxyphenylpyruvate inhibitor, showing the highest predicted activity and strongest binding compared to the best experimental compound. Free computational tools guided candidate selection, predicted interactions with the enzyme, and confirmed stable binding.
Capucho LR, Cunha EFF, Freitas MP.
europepmc   +2 more sources

Investigation into the Binding Site of (-)-Spirobrassinin for Herbicidal Activity Using Molecular Docking and Molecular Dynamics Simulations

Applied Sciences, 2023
(-)-Spirobrassinin, a glucosinolate compound from Brassicaceae plants, has shown inhibitory effects on weeds. However, its specific target sites are not well explored.
Yu Wang, Baozhu Dong, Dong Wang, Xinyu Jia, Qian Zhang, Wanyou Liu, Hongyou Zhou   +6 more
doaj   +1 more source

Discovery of Bis-5-cyclopropylisoxazole-4-carboxamides as Novel Potential 4‑Hydroxyphenylpyruvate Dioxygenase Inhibitors

, 2023
4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27; HPPD) represents a potential target for novel herbicide development. To discover the more promising HPPD inhibitor, we designed and synthesized a series of bis-5-cyclopropylisoxazole-4-carboxamides with
Haiyan Liu (51889), Yan-En Wang (9741259), Jinlin Zhang (2733973), Miaomiao Chen (763128), Jingqian Huo (5865899), Dongchen Yang (11503276)   +5 more
core   +1 more source

Inhibition of Barnyardgrass 4-Hydroxyphenylpyruvate Dioxygenase by Sulcotrione [PDF]

Plant Physiology, 1994
4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) was partially purified from barnyardgrass (Echinochloa crus-galli L.) leaves and assayed by high-performance liquid chromatography analysis of product formation or by the capture of released 14CO2. The bleaching herbicide sulcotrione [2-(2-chloro-4-methanesulfonylbenzoyl)-1,3-cyclohexanedione] was ...
openaire   +2 more sources

Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway [PDF]

, 1999
Background: In plants and photosynthetic bacteria, the tyrosine degradation pathway is crucial because homogentisate, a tyrosine degradation product, is a precursor for the biosynthesis of photosynthetic pigments, such as quinones or tocophenols ...
Eva Pebay-Peyroula, Cohen-Addad, Claudine, Sy, Denise, Philippe Boudec, Boudec, Philippe, Serre, Laurence, Sailland, Alain, Claudine Cohen-Addad, Rolland, Anne, Denise Sy, Pebay-Peyroula, Eva, Laurence Serre, Alain Sailland, Anne Rolland   +13 more
core   +1 more source

Pharmacophore-Oriented Discovery of Novel 1,2,3-Benzotriazine-4-one Derivatives as Potent 4‑Hydroxyphenylpyruvate Dioxygenase Inhibitors

, 2022
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a functional protein existing in almost all aerobic organisms. In the field of agricultural chemicals, HPPD is acknowledged to be one of the crucial targets for herbicides at present due to its unique bio ...
Qiong Chen (327492), Ren-Yu Qu (2828444), Wei Wu (27708), Guang-Yi Huang (12650148), Wen-Chao Yang (1393606), Guang-Fu Yang (364659), Yao-Chao Yan (9015164), Hong-Yan Lin (1402138)   +7 more
core   +1 more source

Tyrosine metabolic reprogramming coordinated with the tricarboxylic acid cycle to drive glioma immune evasion by regulating PD‐L1 expression

Ibrain, 2023
Due to the existence of the blood–brain barrier in glioma, traditional drug therapy has a poor therapeutic outcome. Emerging immunotherapy has been shown to have satisfactory therapeutic effects in solid tumors, and it is clinically instructive to ...
Ji‐Yan Wang, Xin‐Tong Dai, Qing‐Le Gao, Hong‐Kai Chang, Shuai Zhang, Chang‐Liang Shan, Tao He   +6 more
doaj   +1 more source

The c4h, tat, hppr and hppd genes prompted engineering of rosmarinic acid biosynthetic pathway in Salvia miltiorrhiza hairy root cultures.

PLoS ONE, 2011
Rational engineering to produce biologically active plant compounds has been greatly impeded by our poor understanding of the regulatory and metabolic pathways underlying the biosynthesis of these compounds.
Ying Xiao, Lei Zhang, Shouhong Gao, Saengking Saechao, Peng Di, Junfeng Chen, Wansheng Chen   +6 more
doaj   +1 more source