Results 11 to 20 of about 12,760,006 (203)

The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activity [PDF]

FEBS Letters, 1996
We have cloned and overexpressed rat 4‐hydroxyphenylpyruvate dioxygenase (4HPPD) in Escherichia coli. The soluble, active recombinant enzyme was shown to contain both 4HPPD and α‐ketoisocaproate dioxygenase (αKICD) activity. However, upon truncation of the 14 amino acids at the C‐terminus by site‐directed mutagenesis, the resulting mutant enzyme (rat F
Lee, M, Zhang, Z, MacKinnon, C, Baldwin, J, Crouch, N   +4 more
exaly   +6 more sources

Discovery of 4-Hydroxyphenylpyruvate dioxygenase inhibitors with novel pharmacophores

Advanced Agrochem
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is pivotal in tyrosine metabolism and essential for plant survival. Its inhibition leads to leaf bleaching and plant death.
Tai-Li Yang, Jin Dong, Xin-Long Wang, Jiangqing Dong, Hong-Yan Lin   +4 more
doaj   +3 more sources

Human 4-Hydroxyphenylpyruvate Dioxygenase Gene (HPD)

Genomics, 1997
Overlapping DNA fragments spanning approximately 21 kb of genomic DNA and encompassing the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) have been cloned by screening a human leukocyte genomic library and by PCR amplification of human fibroblastic DNA.
U, Rüetschi, L, Rymo, S, Lindstedt
openaire   +3 more sources

4-Hydroxyphenylpyruvate Dioxygenase Catalysis [PDF]

Journal of Biological Chemistry, 2011
4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) into homogentisate. HPPD is the molecular target of very effective synthetic herbicides. HPPD inhibitors may also be useful in treating life-threatening tyrosinemia type I and are currently in trials for treatment of Parkinson disease.
Corinne Raspail, Matthieu Graindorge, Yohann Moreau, Serge Crouzy, Bertrand Lefèbvre, A.Y. Robin, Renaud Dumas, Michel Matringe   +7 more
openaire   +2 more sources

The Crystal Structures of Zea mays and Arabidopsis 4-Hydroxyphenylpyruvate Dioxygenase [PDF]

Plant Physiology, 2004
Abstract The transformation of 4-hydroxyphenylpyruvate to homogentisate, catalyzed by 4-hydroxyphenylpyruvate dioxygenase (HPPD), plays an important role in degrading aromatic amino acids. As the reaction product homogentisate serves as aromatic precursor for prenylquinone synthesis in plants, the enzyme is an interesting target for ...
Fritze, I., Linden, L., Freigang, J., Auerbach, G., Huber, R., Steinbacher, S.   +5 more
openaire   +5 more sources

Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops [PDF]

Frontiers in Pharmacology
The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplotaxis harra (Forssk.) Boiss., Nerium oleander L., and Retama raetam (Forssk.) Webb. Collected from Tunisian arid regions.
Malak Harabi, Walid Elfalleh, Dhawya Mergby, Abdelkarim Ben Arfa, Ilyes Saidi, Ilyes Saidi, Rania Kaddachi, Hamdi Bendif, Sulaiman A. Alsalamah, Samira Missaoui, Hichem Ben Jannet, Hanen Najjaa   +11 more
doaj   +2 more sources

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science
N6‐methyladenosine (m6A) is a dynamic RNA modification, which is added by the METTL3‐METTL14 methyltransferase complex or METTL16. Unexpectedly, the tyrosine metabolism enzyme 4‐hydroxyphenylpyruvate dioxygenase (HPD) is discovered as a methyltransferase
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
doaj   +2 more sources

Transcriptome and Quasi-Targeted Metabolome Analyze Overexpression of 4-Hydroxyphenylpyruvate Dioxygenase Alleviates Fungal Toxicity of 9-Phenanthrol in Magnaporthe oryzae. [PDF]

Int J Mol Sci, 2022
Magnaporthe oryzae, the causal agent of rice blast disease, produces devastating damage to global rice production. It is urgent to explore novel strategies to overcome the losses caused by this disease. 9-phenanthrol is often used as a transient receptor
Wang Y, Wang Z, Jibril SM, Wei M, Pu X, Yang C, Ma C, Wu Q, Liu L, Quan Y, Li C.   +10 more
europepmc   +2 more sources

Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy

Molecules, 2023
Alkaptonuria (AKU) is a rare genetic autosomal recessive disorder characterized by elevated serum levels of homogentisic acid (HGA). In this disease, tyrosine metabolism is interrupted because of the alterations in homogentisate dioxygenase (HGD) gene ...
Sumera Zaib, Nehal Rana, Nadia Hussain, Hanan A. Ogaly, Ayed A. Dera, Imtiaz Khan   +5 more
doaj   +1 more source

The Discovery of the Mode of Action of Nitisinone

Metabolites, 2022
This review briefly discusses the discovery of the mode of action of the triketone herbicide, 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyclohexanedione and its use as a drug Nitisinone for the treatment of inborn errors of tyrosine metabolism.
Edward A. Lock
doaj   +1 more source