Results 11 to 20 of about 2,273 (170)

In Silico Design and Validation of a Novel HPPD-Inhibiting Herbicide Candidate Based on Benzofuran and Arylthioacetic Acid Scaffolds. [PDF]

Chem Biodivers
A benzofuran‐triketone hybrid emerged as the most promising 4‐hydroxyphenylpyruvate inhibitor, showing the highest predicted activity and strongest binding compared to the best experimental compound. Free computational tools guided candidate selection, predicted interactions with the enzyme, and confirmed stable binding.
Capucho LR, Cunha EFF, Freitas MP.
europepmc   +2 more sources

Discovery of 4-Hydroxyphenylpyruvate dioxygenase inhibitors with novel pharmacophores

Advanced Agrochem
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is pivotal in tyrosine metabolism and essential for plant survival. Its inhibition leads to leaf bleaching and plant death.
Tai-Li Yang, Jin Dong, Xin-Long Wang, Jiangqing Dong, Hong-Yan Lin   +4 more
doaj   +2 more sources

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science
N6‐methyladenosine (m6A) is a dynamic RNA modification, which is added by the METTL3‐METTL14 methyltransferase complex or METTL16. Unexpectedly, the tyrosine metabolism enzyme 4‐hydroxyphenylpyruvate dioxygenase (HPD) is discovered as a methyltransferase
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
doaj   +2 more sources

Quantitative Structure Activity Relationship Studies and Molecular Dynamics Simulations of 2-(Aryloxyacetyl)cyclohexane-1,3-Diones Derivatives as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors [PDF]

Frontiers in Chemistry, 2019
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a significant enzyme in the biosynthesis of plastoquinone and tocopherol. Moreover, it is also a potential target to develop new herbicide. The technology of computer-aided drug design (CADD) is a useful tool
Ying Fu, Yong-Xuan Liu, Ke-Han Yi, Ming-Qiang Li, Jia-Zhong Li, Fei Ye   +5 more
doaj   +2 more sources

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione-resistant Amaranthus tuberculatus biotype. [PDF]

Pest Manag Sci
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Laforest M, Bessette M, Gagnon G, Flores-Mejia S, Soufiane B, Goulet MC, Michaud D.   +6 more
europepmc   +2 more sources

Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops [PDF]

Frontiers in Pharmacology
The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplotaxis harra (Forssk.) Boiss., Nerium oleander L., and Retama raetam (Forssk.) Webb. Collected from Tunisian arid regions.
Malak Harabi, Walid Elfalleh, Dhawya Mergby, Abdelkarim Ben Arfa, Ilyes Saidi, Ilyes Saidi, Rania Kaddachi, Hamdi Bendif, Sulaiman A. Alsalamah, Samira Missaoui, Hichem Ben Jannet, Hanen Najjaa   +11 more
doaj   +2 more sources

The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activity [PDF]

FEBS Letters, 1996
We have cloned and overexpressed rat 4‐hydroxyphenylpyruvate dioxygenase (4HPPD) in Escherichia coli. The soluble, active recombinant enzyme was shown to contain both 4HPPD and α‐ketoisocaproate dioxygenase (αKICD) activity. However, upon truncation of the 14 amino acids at the C‐terminus by site‐directed mutagenesis, the resulting mutant enzyme (rat F
Lee, M, Zhang, Z, MacKinnon, C, Baldwin, J, Crouch, N   +4 more
exaly   +4 more sources

Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy

Molecules, 2023
Alkaptonuria (AKU) is a rare genetic autosomal recessive disorder characterized by elevated serum levels of homogentisic acid (HGA). In this disease, tyrosine metabolism is interrupted because of the alterations in homogentisate dioxygenase (HGD) gene ...
Sumera Zaib, Nehal Rana, Nadia Hussain, Hanan A. Ogaly, Ayed A. Dera, Imtiaz Khan   +5 more
doaj   +1 more source

The Discovery of the Mode of Action of Nitisinone

Metabolites, 2022
This review briefly discusses the discovery of the mode of action of the triketone herbicide, 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyclohexanedione and its use as a drug Nitisinone for the treatment of inborn errors of tyrosine metabolism.
Edward A. Lock
doaj   +1 more source

Leigh syndrome-like MRI changes in a patient with biallelic HPDL variants treated with ketogenic diet

Molecular Genetics and Metabolism Reports, 2021
Biallelic 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) variants were recently reported as a cause of progressive and incurable neurodegenerative diseases ranging from neonatal-onset leukoencephalopathy with severe neurodevelopmental delay to ...
Yurika Numata-Uematsu, Mitsugu Uematsu, Toshiyuki Yamamoto, Hirotomo Saitsu, Yu Katata, Yoshitsugu Oikawa, Naoya Saijyo, Takehiko Inui, Kei Murayama, Akira Ohtake, Hitoshi Osaka, Jun-ichi Takanashi, Shigeo Kure, Ken Inoue   +13 more
doaj   +1 more source