Results 21 to 30 of about 12,760,006 (203)

Leigh syndrome-like MRI changes in a patient with biallelic HPDL variants treated with ketogenic diet

open access: yesMolecular Genetics and Metabolism Reports, 2021
Biallelic 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) variants were recently reported as a cause of progressive and incurable neurodegenerative diseases ranging from neonatal-onset leukoencephalopathy with severe neurodevelopmental delay to ...
Yurika Numata-Uematsu   +13 more
doaj   +1 more source

Pyomelanin produced by Streptomyces sp. ZL-24 and its protective effects against SH-SY5Y cells injury induced by hydrogen peroxide

open access: yesScientific Reports, 2021
A soluble melanin pigment produced by Streptomyces sp. ZL-24 was purified and named StrSM. The elemental analysis of StrSM showed it consists of carbon, hydrogen, and oxygen.
Yumei Li   +3 more
doaj   +1 more source

The mutation spectrum and ethnic distribution of non-hepatorenal tyrosinemia (types II, III)

open access: yesOrphanet Journal of Rare Diseases, 2022
Background Different types of non-hepatorenal tyrosinemia are among the rare forms of tyrosinemia. Tyrosinemia type II and III are autosomal recessive disorders caused by pathogenic variants in the tyrosine aminotransferase (TAT), and 4-hydroxyphenyl ...
Zahra Beyzaei   +3 more
doaj   +1 more source

Bioinformatics analysis of 4Hppd gene in Sporothrix schenckii

open access: yesPifu-xingbing zhenliaoxue zazhi, 2020
Objective: To predict biological characterisics of 4-HppD, encoded by 4Hppd in Sporothrix schenckii. Methods: Mutiple bioinformatics online tools were used to analyse the sequence.
Xiao-yan WU   +8 more
doaj   +1 more source

Discovery of tetrazolium nicotinamide derivatives as novel 4-Hydroxyphenylpyruvate dioxygenase inhibiting-based herbicides

open access: yesAdvanced Agrochem, 2023
4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is currently one of the popular targets of herbicide research, and herbicides targeting it have shown promising results in treating resistant weeds.
Li-Jun Chen   +6 more
doaj   +1 more source

Characterization of 4‐hydroxyphenylpyruvate dioxygenase [PDF]

open access: yesEuropean Journal of Biochemistry, 1992
The primary structure of Pseudomonas 4‐hydroxyphenylpyruvate dioxygenase was determined. Sequence degradation of the intact protein and of peptides from three different digests of the carboxymethylated protein established a 357‐residue polypeptide chain with a free α‐amino group.
U, Rüetschi   +5 more
openaire   +3 more sources

Role of Substrate Positioning in the Catalytic Reaction of 4‑Hydroxyphenylpyruvate DioxygenaseA QM/MM Study

open access: yes, 2016
Ring hydroxylation and coupled rearrangement reactions catalyzed by 4-hydroxy­phenyl­pyruvate dioxygenase were studied with the QM/MM method ONIOM­(B3LYP:AMBER).
Tomasz Borowski (1735858)   +5 more
core   +6 more sources

Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2‐dioxygenase deficiency in the liver is responsible for homogentisic acid‐derived ochronotic pigmentation

open access: yesJIMD Reports, 2021
Alkaptonuria (AKU) is caused by homogentisate 1,2‐dioxygenase (HGD) deficiency. This study aimed to determine if HGD and other enzymes related to tyrosine metabolism are associated with the location of ochronotic pigment. Liver, kidney, skin, bone, brain,
Peter J. M. Wilson   +4 more
doaj   +1 more source

Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress

open access: yesAdvanced Agrochem, 2022
The upregulation of 4-hydroxyphenylpyruvate dioxygenase (HPPD) can protect plants from adverse abiotic stress. Therefore, studying the changes of HPPD under abiotic stress is extremely valuable.
Xiaoyan Zeng   +10 more
doaj   +1 more source

Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors

open access: yesBeilstein Journal of Organic Chemistry, 2020
A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising Arabidopsis thaliana HPPD (AtHPPD) inhibitors, in ...
Man-Man Wang   +6 more
doaj   +1 more source

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