Results 21 to 30 of about 2,253 (135)
Role of the N-terminus in human 4-hydroxyphenylpyruvate dioxygenase activity
The Journal of Biochemistry, 2019 Abstract4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a key enzyme in tyrosine catabolism, catalysing the oxidation of 4-hydroxyphenylpyruvate to homogentisate. Genetic deficiency of this enzyme causes type III tyrosinaemia. The enzyme comprises two barrel-shaped domains formed by the N- and C-termini, with the active site located in the C-terminus ...
An-Ning, Feng +5 more
openaire +2 more sources
Pest Management Science, Volume 82, Issue 7, Page 6387-6398, July 2026.Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest +6 more
wiley +1 more source
Structure of the Human 4-Hydroxyphenylpyruvic Acid Dioxygenase Gene (HPD)
Genomics, 1994 4-Hydroxyphenylpyruvic acid dioxygenase (HPD) is an important enzyme in tyrosine catabolism in most organisms. The activity of this enzyme is expressed mainly in the liver and developmentally regulated in mammals, and a genetic deficiency in this enzyme in humans and mice leads to hereditary tyrosinemia type 3.
H, Awata, F, Endo, I, Matsuda
openaire +2 more sources
Thirty years of glyphosate‐resistant crops and weeds: Current situation and future prospects
Pest Management Science, Volume 82, Issue 7, Page 5987-6009, July 2026.Since 1996, when the first glyphosate‐resistant crop was commercialized and the first resistant weed was reported, resistance has expanded globally. This review analyzes emergence patterns across weed species, crops, regions, resistance mechanisms, and herbicides.
Ricardo Alcántara‐de la Cruz +7 more
wiley +1 more source
EFSA Journal, Volume 24, Issue 7, July 2026.Abstract Following the submission of dossier GMFF‐2025‐33580 under Regulation (EC) No 1829/2003 from Syngenta Crop Protection AG, the Panel on Genetically Modified Organisms of the EFSA was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the herbicide‐tolerant ...
EFSA Panel on Genetically Modified Organisms (GMO) +19 more
wiley +1 more source
Crop, Forage &Turfgrass Management, Volume 12, Issue 2, December 2026.
Daniel Q. Zhu +2 more
wiley +1 more source
Assessment of genetically modified soybean DAS‐44406 × FG72 (dossier GMFF‐2025‐34192)
EFSA Journal, Volume 24, Issue 7, July 2026.Abstract Genetically modified soybean DAS‐44406‐6 × FG72 was developed by conventional crossing to combine two single events: DAS‐44406‐6 and FG72. The soybean DAS‐44406‐6 × FG72 expresses the AAD‐12, 2mEPSPS, PAT and HPPD W336 proteins to confer herbicide tolerance to 2,4‐D‐, glyphosate‐, glufosinate‐containing and HPPD‐inhibiting herbicide products ...
EFSA Panel on Genetically Modified Organisms (GMO) +28 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 4, April 2026.A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Shugo Yajima +12 more
wiley +1 more source
Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 985-1012, April 2026.For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Ruiqi Zhang +7 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2204-2219, April 2026.ABSTRACT Plant biofortification with phytonutrients typically relies on metabolic engineering strategies known as ‘push’ (enhancing biosynthetic flux), ‘block’ (inhibiting competing pathways) and ‘pull’ (promoting metabolite storage). Here, we describe a novel synthetic compound, X57, that simultaneously targets biosynthesis, competition and storage to
Pablo Perez‐Colao +4 more
wiley +1 more source