Results 71 to 80 of about 2,273 (170)

The Incidence of Transient Neonatal Tyrosinemia Within a Mexican Population

Journal of Inborn Errors of Metabolism and Screening, 2017
Transient neonatal tyrosinemia (TNT) is a form of hypertyrosinemia produced by the immaturity of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD), a high intake of phenylalanine and tyrosine, and a relative ascorbic acid deficiency.
Alexandra V. Zea-Rey MD, Héctor Cruz-Camino BSc, Diana L. Vazquez-Cantu BSc, Valeria M. Gutiérrez-García BSc, Jesús Santos-Guzmán PhD, Consuelo Cantú-Reyna MD   +5 more
doaj   +1 more source

H2S‐Mediated GH3.1 Persulfidation Regulates IAA Homeostasis to Enhance Nodulation Formation and Nitrogen Fixation in Robinia pseudoacacia

Molecular Plant Pathology, Volume 26, Issue 10, October 2025.
H2S persulfidates GH3.1 at Cys304, reducing its activity, sustaining IAA levels, triggering H2S‐IAA feedback, enhancing nodulation gene expression, boosting nodule formation, nitrogen fixation and Robinia pseudoacacia growth. ABSTRACT Hydrogen sulphide (H2S), a gaseous signalling molecule, plays a multifaceted role in plant physiology by enhancing ...
Weiqin Zhang, Huaping Cheng, Xiaowu Yan, Bingyu Suo, Shiming Wen, Wuyu Liu, Gehong Wei, Juan Chen   +7 more
wiley   +1 more source

Hawkinsinuria clinical practice guidelines: a Mexican case report and literature review

Journal of International Medical Research, 2020
Hawkinsinuria is an autosomal dominant disorder of tyrosine metabolism. Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene ( HPD ) result in an altered HPD enzyme, causing hawkinsin and tyrosine accumulation.
Héctor Cruz-Camino, Diana Laura Vazquez-Cantu, Alexandra Vanessa Zea-Rey, Jaime López-Valdez, Jorge Jiménez-Lozano, René Gómez-Gutiérrez, Consuelo Cantú-Reyna   +6 more
doaj   +1 more source

The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake

Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide.
Zachary Thomas Stavrou-Dowd, George Parsons, Clair Rose, Faye Brown, Rosemary Susan Lees, Álvaro Acosta-Serrano, Lee Rafuse Haines   +6 more
doaj   +1 more source

HPDL Variant Type Correlates With Clinical Disease Onset and Severity

Annals of Clinical and Translational Neurology
Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic ...
Eun Hye Lee, Olivia Kim‐Mcmanus, Jennifer H. Yang, Richard Haas, Maha S. Zaki, Ghada M. H. Abdel‐Salam, Yuji Nakamura, Mohamed S. Abdel‐Hamind, Darius Ebrahimi‐Fakhari, Julian E. Alecu, Nicola Brunetti‐Pierri, Varunvenkat M. Srinivasan, Vykuntaraju K. Gowda, Stephanie Gross, Yasemin Alanay, Paria Najarzadeh Totbati, Manya Yadavilli, Liana Friedman, Naomi Meave Ojeda, Joseph G. Gleeson   +19 more
doaj   +1 more source

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes

FEBS Open Bio, 2019
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed.
José Mário F. Balanco, Rodrigo A.C. Sussmann, Ignasi B. Verdaguer, Heloisa B. Gabriel, Emilia A. Kimura, Alejandro M. Katzin   +5 more
doaj   +1 more source

Computer-Aided and AILDE Approaches to Design Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. [PDF]

Int J Mol Sci, 2022
Shi J, Gao S, Wang JY, Ye T, Yue ML, Fu Y, Ye F.   +6 more
europepmc   +1 more source

Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation. [PDF]

Arch Toxicol, 2023
Botham J, Lewis RW, Travis KZ, Baze A, Richert L, Codrea E, Semino Beninel G, Garcin JC, Strupp C.   +8 more
europepmc   +1 more source

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science
4‐hydroxyphenylpyruvate dioxygenase (HPD) is an important metabolic enzyme in the tyrosine metabolic pathway and displays aberrant expression and function in cancer.
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
doaj   +1 more source

Transcriptome and Quasi-Targeted Metabolome Analyze Overexpression of 4-Hydroxyphenylpyruvate Dioxygenase Alleviates Fungal Toxicity of 9-Phenanthrol in Magnaporthe oryzae. [PDF]

Int J Mol Sci, 2022
Wang Y, Wang Z, Jibril SM, Wei M, Pu X, Yang C, Ma C, Wu Q, Liu L, Quan Y, Li C.   +10 more
europepmc   +1 more source