Results 171 to 180 of about 12,849,117 (223)

Structure-Based Design, Synthesis, and Biological Evaluation of Oxadiazole-Morpholine Hybrids as Potent PARP-1 Inhibitors Inducing Apoptosis in Breast Cancer Cells. [PDF]

Drug Dev Res
Albujuq NR, Darwish KM, Fahmy SA, Hussein B, Kayed GG, Said MA, Nafie MS.   +6 more
europepmc   +1 more source

Targeting ALDH7A1 with covalent inhibitors reveals new chemical space for prostate cancer therapy. [PDF]

J Enzyme Inhib Med Chem
Gallo R, Scarano A, Gianquinto E, Franzini G, Antonini G, Montalbano S, Palmieri C, Conti P, Spyrakis F, Borsari C, Bruno S.   +10 more
europepmc   +1 more source

Synthesis and structure–activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase

Bioorganic and Medicinal Chemistry, 2009
International audienceA series of per-O-benzoylated 5-beta-D-glucopyranosyl-2-substituted-1,3,4-oxadiazoles was prepared by acylation of the corresponding 5-(beta-D-glucopyranosyl)tetrazole.
Sébastien Vidal, Sándor Kun, László Somsák   +2 more
exaly   +2 more sources

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An Overview: 1, 3, 4- oxadiazole and its uses

Asian Journal of Research in Chemistry, 2021
Heterocyclic compounds show various potent biological activity. Every heterocyclic compound has different structure, different functional group and designed for different biological activities. Oxadiazole is one of those heterocyclic compounds possess various biological activity. The structure is simple contain carbon, nitrogen, oxygen, hydrogen.
Anuja S. Patil., Shrinivas K. Mohite
openaire   +1 more source

Synthesis of 1, 3, 4-Oxadiazole

Asian Journal of Research in Chemistry, 2017
Synthesis of 1, 3, 4-oxadiazole by the reaction of 2-propyl Benzo imidiazol-2-yl carbohydrazide and 1, 3, dihydro iso indo-2-yl acetic acid (Phthalyl Amino Acids) in presence of HCl and phosphoryl chloride. All the newly synthesized compounds were screened antibacterial activity which shows moderate to mild activity, and yield of the synthesized ...
Maqdoom Farooqui, Syed Nazimuddin
openaire   +1 more source

[1, 2, 4]-Oxadiazoles: Synthesis and Biological Applications

Mini-Reviews in Medicinal Chemistry, 2014
In the present article synthesis and medicinal applications of [1, 2, 4] oxadiazoles are reviewed. The oxadiazoles have a wide range of applications such as Antitussive, Anti-inflammatory, Anaesthetic, Vasodilator, anthelmintic, antiallergic, antiplatelet effects in vitro, antithrombotic properties in vivo, etc.
Rajesh O, Bora, Bashir, Dar, Vidya, Pradhan, Mazahar, Farooqui   +3 more
openaire   +2 more sources

2, 5-Dialkyl-1, 3, 4-oxadiazoles

Chemistry of Heterocyclic Compounds, 1970
A single stage method has been developed for the preparation of 2, 5-dialky-1, 3, 4-oxadiazoles from aliphatic carboxylic acids, by boiling with hydrazine hydrochloride in phosphoryl chloride. A mechanism for the synthesis is suggested. The oxadiazoles are characterized, and the group refractivity of the 1, 3, 4-oxadiazole ring has been determined.
M. S. Skorobogatova, Ya. A. Levin, O. A. Raevskii   +2 more
openaire   +1 more source

Synthesis and study of poly (1, 3, 4-oxadiazoles)

Chemistry of Heterocyclic Compounds, 1967
Various conditions for synthesizing poly (1,3,4-oxadiazoles) from carboxylic acids, their hydrazides, and polyhydrazides, are investigated. Methods of cyclodehydration of polyhydrazides using phosphorus oxychloride, sulfuric acid, and certain other reagents are not of general utility for synthesizing poly (1,3,4-oxadiazoles).
A. P. Grekov, S. A. Malyutenko, K. A. Kornev   +2 more
openaire   +1 more source

Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents

2021
In the present investigation a new series of 1, 3, 4-oxadiazoles (3a-j) were synthesized by reacting INH (1) and substituted aromatic acids (2) in presence of POCl3. The new compounds were established on the basis of IR, 1H NMR and Mass spectral data.
B. C. Revanasiddappa, E. V. S. Subrahmanyam   +1 more
openaire   +1 more source