Results 71 to 80 of about 346,502 (202)

Highlight on the problems generated by p-coumaric acid analysis in fermentations [PDF]

, 2008
p-Coumaric acid is a natural hydroxycinnamic acid existing in grapes and wine. It is the precursor of the 4-ethylphenol molecule through the bioconversion reaction by Brettanomyces yeast. Chromatographic methods are the most common techniques to detect p-
Dominique Salameh, Cédric Brandam, Brandam, Cédric, Wissam Medawar, Salameh, Dominique, Lteif, Roger, Strehaiano, Pierre, Pierre Strehaiano, Medawar, Wissam, Roger Lteif   +9 more
core   +1 more source

Expanding Role of Endogenous Biomarkers for Assessment of Transporter Activity in Drug Development: Current Applications and Future Horizon

Pharmaceutics
The evaluation of transporter-mediated drug–drug interactions (DDIs) during drug development and post-approval contributes to benefit–risk assessment and helps formulate clinical management strategies.
Vikram Arya, Joseph D. Ma, Kine Eide Kvitne   +2 more
doaj   +1 more source

Icariin Alleviates Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice by Modulating the Gut–Lung Axis and Serum Metabolism

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of uncertain etiology with few specific and effective therapeutic agents approved for its treatment. We examined the underlying processes and the impact of icariin (ICA) on a bleomycin‐induced pulmonary fibrosis model.
Ting Zhang, Weiyi Gong, Cheng Huang, Hongkai Wang, Baojun Liu, Dawei Cui   +5 more
wiley   +1 more source

Two-dimensional hydrogen-bonded polymers in the crystal structures of the ammonium salts of phenoxyacetic acid, (4-fluorophenoxy)acetic acid and (4-chloro-2-methylphenoxy)acetic acid

, 2014
The structures of the ammonium salts of phenoxyacetic acid, NH4+·C8H6O3−, (I), (4-fluorophenoxy)acetic acid, NH4+·C8H5FO3−, (II), and the herbicidally active (4-chloro-2-methylphenoxy)acetic acid (MCPA), NH4+·C9H8ClO3−·0.5H2O, (III) have been determined.
Smith, Graham, Graham Smith
core   +1 more source

Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]

, 2004
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Thiessen, K., Parhofer, K. G., Fischer, S., Sauter, G. H., Jungst, D., Jungst, C.   +5 more
core   +1 more source

Simultaneous Fluorometric Resolution of Pyridoxal, Pyridoxamine and 4-Pyridoxic Acid Using Chemometric Methods

Analytical Sciences, 2007
An alternatively minimizing covariant matrix error (AMCME) algorithm, newly proposed by the present authors, was applied to the simultaneous fluorometric determination of pyridoxal, pyridoxamine and 4-pyridoxic acid without loss of sensitivity. The experimental results illustrate that the profiles of spectra and concentration can be accurately resolved
MO, Cui-Yun, CAO, Yu-Zhen
openaire   +3 more sources

Periodontitis Salivary Microbiota Exacerbates Murine Rheumatoid Arthritis via Gut Dysbiosis and Immune Dysregulation

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
Salivary multiomics from healthy, PD, RA, and PD‐RA cohorts identified PD−/RA‐linked microbial and metabolic signatures. We then transplanted salivary microbiota from a PD donor or a healthy donor into collagen‐induced arthritis mice. PD microbiota colonized the gut, reshaped communities, weakened epithelial tight junctions, and provoked systemic ...
Ruiyang Ge, Rong Liu, Yingying Zhou, Ziyao Zhuang, Haowei Mao, Wenzheng Liao, Lei Han, Wenrong Yang, Fuhua Yan, Di Cui   +9 more
wiley   +1 more source

Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate (GCDCA‐S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1532-1542, December 2025.
Endogenous biomarkers for drug transporters are an emerging tool for the assessment of transporter‐mediated drug–drug interactions (DDI). Glycochenodeoxycholic acid 3‐O‐sulfate (GCDCA‐S) has been proposed as a Tier 2 biomarker of hepatic OATP1B3 and renal OAT3 transporters by the International Transporter Consortium.
Yuki Ujihira, Viktor Georgiev, Kayode Ogungbenro, Aleksandra Galetin   +3 more
wiley   +1 more source

Urinary total flavonoid excretion but not 4-pyridoxic acid or potassium can be used as a biomarker for the intake of fruits and vegetables

, 2004
To gain better insight into the potential health effects of fruits and vegetables, reliable biomarkers of intake are needed. The main purpose of this study was to investigate the ability of flavonoid excretion in both 24-h and morning urine samples to ...
Knuthsen, Pia, Kirstine S. Krogholm, Salka E. Rasmussen, Rasmussen, Salka E., Jóhanna Haraldsdóttir, Krogholm, Kirstine Suszkiewicz, Rasmussen, S.E., Haraldsdottir, Johanna, Pia Knuthsen, Haraldsdottir, J., Krogholm, Kirstine S., Knuthsen, P.   +11 more
core   +1 more source

Integration of Bioinformatics, Serum Pharmacochemistry, and Metabolomics to Reveal the Mechanisms of Danggui Buxue Decoction in Anti‐Rheumatoid Arthritis Through Inflammation and NF‐κB Signaling Pathway Regulation

Immunity, Inflammation and Disease, Volume 13, Issue 9, September 2025.
ABSTRACT Objective Rheumatoid arthritis (RA) remains a significant clinical challenge due to the limited efficacy and adverse effects associated with conventional treatments. Danggui buxue decoction (DBD), renowned for its qi‐tonifying, blood‐nourishing, and anti‐inflammatory properties, has shown promising potential in the management of RA. This study
Lianyun Du, Ye Zhai, Meixiu Luo, Lu Tang, Saiyue Qiu, Xin Jiang, Enpeng Wang, Zhi Pan   +7 more
wiley   +1 more source