Results 81 to 90 of about 346,502 (202)

Effectiveness of Pyridoxal‐5′‐Phosphate in PNPO Deficiency: A Systematic Review

open access: yesJournal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Pyridox(am)ine 5′‐phosphate oxidase (PNPO) deficiency is an ultrarare inherited neurometabolic disease, characterized by primarily neonatal‐onset B6‐responsive epileptic encephalopathies. Treatment often requires sustainable access to high‐quality pyridoxal‐5′‐phosphate (PLP, i.e., active vitamin B6), although some patients (also) respond to ...
Nina N. Stolwijk   +7 more
wiley   +1 more source

Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development

open access: yesClinical and Translational Medicine, Volume 15, Issue 8, August 2025.
This finding could lead to clinical diagnosis of CA severity and provide new treatment strategies. A novel panel composed of five metabolites can be used to accurately diagnose the development of CA. Abstract Background Coronary atherosclerosis (CA) is a leading cause of cardiovascular diseases with the high morbidity and mortality; however, the ...
Mengxue He   +10 more
wiley   +1 more source

[A comparison of methods of determining 4-pyridoxic acid in urine].

open access: yesVoprosy pitaniia, 1993
Routine fluorescent assays for urine 4-pyridoxic acid (4-PA) in variants of lactone 4-PA external standard (variant 1) and internal 4-PA standard (variant 2) were compared to high performance liquid chromatography. Correlation between the two values were defined by specially derived equation.
N A, Beketova   +5 more
openaire   +1 more source

Temporal response patterns of human gut microbiota to dietary fiber

open access: yesiMeta, Volume 4, Issue 4, August 2025.
In this study, 19 overweight participants, with or without type 2 diabetes mellitus, underwent 14 days of normal‐diet observation followed by 14 days of dietary fiber intervention. Fecal samples and continuous glucose monitoring data were collected daily throughout the 28‐day period.
Xiaotong Lin   +5 more
wiley   +1 more source

The effect of protein intake on the excretion of vitamin B₆, 4-pyridoxic acid, and xanthurenic acid in preadolescent boys

open access: yes, 1975
The effect of protein intake on vitamin B6 status was investigated in preadolescent boys. Twelve subjects rotated through a diet sequence containing daily intakes of 1.15 mg vitamin B6 and 29, 54, or 84 rim protein.
Johnson, Frances Somervell
core  

Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121)

open access: yes, 2011
YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid.
Gabler, Matthias   +3 more
core   +1 more source

Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB

open access: yesAnimal Models and Experimental Medicine, Volume 8, Issue 7, Page 1268-1276, July 2025.
Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang   +9 more
wiley   +1 more source

Finding the oleic acid amount in 4 different types of oil by Acid – Base Titration Method [PDF]

open access: yes, 2010
Anywhere in the world most people use vegetable oil in every area of their life. Food, health, mechanic, hygiene and so on… But how people choose the kind of oil that they will use?
Yıldız, Aysu
core  

Metabolomic Insights into Primary and Secondary Metabolites Variation in Common and Glutinous Rice (Oryza sativa L.)

open access: yesAgronomy
: Interest in glutinous rice consumption has been expanding in East Asia. However, the extent of metabolite variation between common and glutinous rice has not been fully explored to identify metabolic targets for rice quality improvement.
Mingchao Zhao   +11 more
doaj   +1 more source

Nanostructured lead-acid negative electrode with reduced graphene oxide

open access: yes, 2021
Aim of this work is to develop a new nano-structured and nano-composite lead acid negative electrode with reduced graphene oxide (rGO). Nanostructured electrodes are fabricated by template electrodeposition of lead nanowires on a lead current collector ...
Oliveri L.   +6 more
core  

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