Electroreductive Intermolecular Coupling of 4‑Quinolones with Benzophenones: Synthesis of 2‑Substituted 4‑Quinolones [PDF]
ACS Omega, 2019 The electroreductive coupling of 1-alkoxycarbonyl-4-quinolones with benzophenones in the presence of trimethylsilyl chloride gave adducts reacted at the 2-position of 4-quinolones as trimethylsilyl ethers. The adducts were transformed to 2-(diarylhydroxymethyl)-4-quinolones.
Naoki Kise +3 more
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Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors [PDF]
Beilstein Journal of Organic Chemistry, 2023 β-Keto amides were used as convenient precursors to both 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides. The utility of this approach is demonstrated with the synthesis of fourteen novel and four known quinolone derivatives, including ...
Yordanka Mollova-Sapundzhieva +3 more
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Hydrogen Bond Assisted Three-Component Tandem Reactions to Access N-Alkyl-4-Quinolones [PDF]
Molecules, 2023 Hydrogen-bonding catalytic reactions have gained great interest. Herein, a hydrogen-bond-assisted three-component tandem reaction for the efficient synthesis of N-alkyl-4-quinolones is described.
Huanhuan Liu +8 more
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Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties [PDF]
Molecules, 2020 The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the Pseudomonas and Burkholderia genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of
Muhammad Saalim +2 more
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Hypervalent Iodine(III)-Promoted C3–H Regioselective Halogenation of 4‑Quinolones under Mild Conditions [PDF]
ACS Omega, 2021 Fang Yang +4 more
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Synthesis and Antibacterial Evaluation of a New Series of <em>N</em>-Alkyl-2-alkynyl/(<em>E</em>)-alkenyl-4-(1<em>H</em>)-quinolones [PDF]
Molecules, 2012 To gain further insight into the structural requirements of the aliphatic group at position 2 for their antimycobacterial activity, some <em>N</em>-alkyl-4-(1<em>H</em>)-quinolones bearing position 2 alkynyls with various chain ...
Abraham Wube +8 more
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Potentials of N-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol as novel charge transfer acceptors in pharmaceutical analysis of some quinolones and cephalosporins [PDF]
Future Journal of Pharmaceutical Sciences, 2022 Background Quinolones and cephalosporins are antibiotic agents with activity against Gram-positive and Gram-negative bacteria. They contain chromophores and amine groups which are electron-rich centres capable of donating electrons to electron-deficient ...
O. E. Umoh, O. A. Adegoke, D. E. Effiong
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Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa. [PDF]
PLoS Pathog, 2016 Rampioni G +9 more
europepmc +3 more sources
Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones [PDF]
Advanced Pharmaceutical Bulletin, 2018 To describe the chemical structure and characterize physico-chemical properties of organometallic complexes it is necessary to use a complex set of analysis methods. Thus, this review has been compiled as a relevant guide which includes the most commonly
Aura Rusu, Gabriel Hancu, Silvia Imre
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Pharmaceuticals, 2022 Quinolones are one of the most extensively used therapeutic families of antibiotics. However, the increase in antibiotic-resistant bacteria has rendered many of the available compounds useless.
Beatriz Suay-García +5 more
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