Hypervalent Iodine(III)-Promoted C3–H Regioselective Halogenation of 4‑Quinolones under Mild Conditions [PDF]
ACS Omega, 2021 A simple and practical protocol for the C3–H regioselective halogenation of 4-quinolones by the action of potassium halide salt and PIFA/PIDA in good to excellent yields was developed.
Fang Yang +4 more
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Electroreductive Intermolecular Coupling of 4‑Quinolones with Benzophenones: Synthesis of 2‑Substituted 4‑Quinolones [PDF]
ACS Omega, 2019 The electroreductive coupling of 1-alkoxycarbonyl-4-quinolones with benzophenones in the presence of trimethylsilyl chloride gave adducts reacted at the 2-position of 4-quinolones as trimethylsilyl ethers.
Naoki Kise +3 more
doaj +9 more sources
Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa. [PDF]
PLoS Pathog, 2016 The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents.
Rampioni G +9 more
europepmc +15 more sources
Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties [PDF]
Molecules, 2020 The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the Pseudomonas and Burkholderia genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of
Muhammad Saalim +2 more
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Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors [PDF]
Beilstein Journal of Organic Chemistry, 2023 β-Keto amides were used as convenient precursors to both 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides. The utility of this approach is demonstrated with the synthesis of fourteen novel and four known quinolone derivatives, including ...
Yordanka Mollova-Sapundzhieva +3 more
doaj +2 more sources
Hydrogen Bond Assisted Three-Component Tandem Reactions to Access N-Alkyl-4-Quinolones [PDF]
Molecules, 2023 Hydrogen-bonding catalytic reactions have gained great interest. Herein, a hydrogen-bond-assisted three-component tandem reaction for the efficient synthesis of N-alkyl-4-quinolones is described.
Huanhuan Liu +8 more
doaj +2 more sources
Effective Synthesis of 4-Quinolones by Reductive Cyclization of 2′-Nitrochalcones Using Formic Acid as a CO Surrogate [PDF]
Molecules, 2023 4-Quinolones are the structural elements of many pharmaceutically active compounds. Although several approaches are known for their synthesis, the introduction of an aryl ring in position 2 is problematic with most of them. The reductive cyclization of o-
Francesco Ferretti +3 more
doaj +2 more sources
Novel Synthesis of 1,2-Substituted 4-Quinolones
SynOpen, 2018 An efficient method for the straightforward synthesis of N-functionalized 4-quinolones and 1,2-substituted 4-quinolones from simple 2-aminoacetophenones has been developed.
Sreenivasulareddy Bandatmakuru +1 more
doaj +2 more sources
Synthesis and Antibacterial Evaluation of a New Series of <em>N</em>-Alkyl-2-alkynyl/(<em>E</em>)-alkenyl-4-(1<em>H</em>)-quinolones [PDF]
Molecules, 2012 To gain further insight into the structural requirements of the aliphatic group at position 2 for their antimycobacterial activity, some <em>N</em>-alkyl-4-(1<em>H</em>)-quinolones bearing position 2 alkynyls with various chain ...
Abraham Wube +8 more
doaj +2 more sources
Recent Advances in the Catalytic Synthesis of 4-Quinolones [PDF]
Chem, 2019 Chao Shen +6 more
openalex +2 more sources