Results 31 to 40 of about 32,766 (293)
Invitro Susceptibility of the Fish Pathogen Aeromonas-Salmonicida to Flumequine [PDF]
, 1991 The activity of the fluoroquinolone flumequine was investigated against the fish pathogen Aeromonas salmonicida and was compared with that of oxolinic acid. Flumequine was more active than oxolinic acid in terms of its MIC against oxolinic acid-resistant
Amyes, Sgb +3 more
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Elimination of plasmids by new 4-quinolones
Antimicrobial Agents and Chemotherapy, 1985 Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa.
J Weisser, B Wiedemann
openaire +3 more sources
Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland [PDF]
, 2012 Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections.
Allison, L.J. +16 more
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DNA breakdown by the 4-quinolones and its significance [PDF]
Journal of Medical Microbiology, 1990 DNA breakdown occurred in Escherichia coli KL16 exposed to nalidixic acid, ciprofloxacin or norfloxacin. However DNA breakdown does not seem to be the cause of the lethality of the 4-quinolones because it still occurred under conditions which abolished the lethality of nalidixic acid.
C. S. Lewin, J. T. Smith
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Beilstein Journal of Organic Chemistry, 2019 Selectively methylated analogues of naturally occurring 2-heptyl-4(1H)-quinolones, which are alkaloids common within the Rutaceae family and moreover are associated with quorum sensing and virulence of the human pathogen Pseudomonas aeruginosa, have been
Sven Thierbach +3 more
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Communications Chemistry, 2022 Quinolones can possess desirable antibacterial, antiviral and anticancer properties, rending them important synthetic targets for drug discovery purposes.
Feng-Wei Guo +7 more
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알코올과 메틸아렌으로부터 철-촉매하에 산화 결합을 통한 N-헤테로고리 화합물의 직접적인 합성 [PDF]
, 2023 학위논문(박사) -- 서울대학교대학원 : 약학대학 약학과, 2023. 8. 홍석창.질소를 포함하는 헤테로고리 화합물은 다양한 생리활성을 가지거나 또는 천연물에서 주로 발견되는 구조로 알려져 있다. 상용화된 저분자 의약품들 중에 N-헤테로고리 화합물구조가 핵심 골격으로 사용되는 것을 볼 수 있는데, 이는 N-헤테로고리 화합물이 타겟 단백질의 아미노산과 중요한 상호작용을 형성하여 다양한 생리활성을 나타낼 수 있기 때문이다. 이러한 타겟 단백질의 생리활성을
이석범
core
Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it [PDF]
, 2005 Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of intercalators, groove binders or electrostatic binders to the backbone.
Altman +50 more
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Nonclassical Biological Activities of Quinolone Derivatives
Journal of Pharmacy & Pharmaceutical Sciences, 2011 Quinolones are considered as a big family of multi-faceted drugs; their chemical synthesis is flexible and can be easily adapted to prepare new congeners with rationally devised structures.
Mohsen Daneshtalab, Abeer Ahmed
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The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa [PDF]
, 2006 Certain members of the fluorescent pseudomonads produce and secrete phenazines. These heterocyclic, redox-active compounds are toxic to competing organisms, and the cause of these antibiotic effects has been the focus of intense research efforts.
Dietrich, Lars E. P. +4 more
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