Results 41 to 50 of about 33,278 (222)
Microwave assisted synthesis of 4-quinolones and N,N′-diarylureas
Green Processing and Synthesis, 2013 4-Quinolinones are an important class of alkaloids, widely used as conventional drugs to treat various infectious diseases. In this study, we report the synthesis of 4-quinolones in one step, under microwave irradiation and with diphenyl ether as a ...
Duarte Patricia D. +2 more
doaj +1 more source
Elimination of plasmids by new 4-quinolones
Antimicrobial Agents and Chemotherapy, 1985 Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa.
J, Weisser, B, Wiedemann
openaire +3 more sources
Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it [PDF]
, 2005 Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of intercalators, groove binders or electrostatic binders to the backbone.
Altman +50 more
core +2 more sources
1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro
Molecules, 2014 A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense, and cytotoxicity against L-6 cells in ...
Abraham Wube +6 more
doaj +1 more source
Metabolites, 2020 Pseudomonas aeruginosa is a ubiquitous environmental bacterium that causes chronic infections of burn wounds and in the lungs of cystic fibrosis (CF) patients.
Andrew C. Lybbert +4 more
doaj +1 more source
Occurrence of multi-antibiotics in chicken and egg samples in Hubei
Zhongguo shipin weisheng zazhi, 2022 ObjectiveTo investigate the residues of quinolones，tetracyclines and metronidazole in chicken and egg samples in Hubei from 2016 to 2019.MethodsA total of 373 chicken and 365 egg samples collected from 15 cities in Hubei Province were detected by ultra ...
XIAO Yonghua +4 more
doaj +1 more source
In-vitro activity of newer quinolones against aerobic bacteria [PDF]
, 2017 Nalidixic and five newer 4-quinolones, ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin were tested against 576 recent clinical aerobic bacterial isolates.
Auckenthaler, R. +2 more
core
Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006 [PDF]
, 1906 Appropriate antimicrobial treatment of shigellosis depends on identifying its changing resistance pattern over time. We evaluated 15,255 stool culture submitted from July 2001 to June 2006 to the Laboratory of Children Medical Center Hospital.
Pourakbari, Babak +6 more
core +1 more source
Advanced Science, EarlyView.Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen +22 more
wiley +1 more source
Direct Optofluidic Measurement of the Lipid Permeability of Fluoroquinolones. [PDF]
, 2016 Quantifying drug permeability across lipid membranes is crucial for drug development. In addition, reduced membrane permeability is a leading cause of antibiotic resistance in bacteria, and hence there is a need for new technologies that can quantify ...
Al Nahas, Kareem +5 more
core +5 more sources