Results 41 to 50 of about 11,679,551 (275)
Communications Chemistry, 2022 Quinolones can possess desirable antibacterial, antiviral and anticancer properties, rending them important synthetic targets for drug discovery purposes.
Feng-Wei Guo +7 more
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Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland [PDF]
, 2012 Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections.
Allison, L.J. +16 more
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Nonclassical Biological Activities of Quinolone Derivatives
Journal of Pharmacy & Pharmaceutical Sciences, 2011 Quinolones are considered as a big family of multi-faceted drugs; their chemical synthesis is flexible and can be easily adapted to prepare new congeners with rationally devised structures.
Mohsen Daneshtalab, Abeer Ahmed
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4-Quinolones: smart phones of the microbial world. [PDF]
Chem Rev, 2011 The cellular telephone has revolutionized the way in which humans communicate. Since its invention, this device has evolved into the multifunctional “smart phone”. The smart phone provides us with not only a means of communication but also a useful toolkit for managing our daily lives.
Huse H, Whiteley M.
europepmc +4 more sources
Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2018 Context: Bacterial resistance to antibiotics is the inevitable consequence of the use of antimicrobial agents. Thus, quinolones are an important class of antibacterials; these agents generally consist of a 1-subtituted-1,4-dihydro-4-oxopyridine-3 ...
Cristian Davila +3 more
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Elimination of plasmids by new 4-quinolones
Antimicrobial Agents and Chemotherapy, 1985 Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa.
J, Weisser, B, Wiedemann
openaire +3 more sources
Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it [PDF]
, 2005 Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of intercalators, groove binders or electrostatic binders to the backbone.
Altman +50 more
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Direct Optofluidic Measurement of the Lipid Permeability of Fluoroquinolones. [PDF]
, 2016 Quantifying drug permeability across lipid membranes is crucial for drug development. In addition, reduced membrane permeability is a leading cause of antibiotic resistance in bacteria, and hence there is a need for new technologies that can quantify ...
Al Nahas, Kareem +5 more
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1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro
Molecules, 2014 A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense, and cytotoxicity against L-6 cells in ...
Abraham Wube +6 more
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Metabolites, 2020 Pseudomonas aeruginosa is a ubiquitous environmental bacterium that causes chronic infections of burn wounds and in the lungs of cystic fibrosis (CF) patients.
Andrew C. Lybbert +4 more
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