Results 11 to 20 of about 3,781 (252)

Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles

Scientifica, 2022
1,3,4-Thiadiazole nuclease, a 5-membered heterocyclic ring system containing two nitrogen and one sulfur atoms in addition to carbon atoms, is compound that showed promising results in the process of searching new diuretic agents. In this study, seven 5-
Asrat Ergena, Yerra Rajeshwar, Gebremedhin Solomon   +2 more
doaj   +1 more source

Palladium-Catalyzed Direct (Het)arylation Reactions of Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole and 4,8-Dibromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)

Molecules, 2023
Palladium-catalyzed direct (het)arylation reactions of strongly electron-withdrawing tricyclic benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) and its 4,8-dibromo derivative were studied; the conditions for the selective formation of mono- and bis-aryl ...
Timofey N. Chmovzh, Timofey A. Kudryashev, Daria A. Alekhina, Oleg A. Rakitin   +3 more
doaj   +1 more source

PHARMACOLOGICAL ACTIVITY OF 5‐PHENYL‐1: 3: 4‐THIADIAZOLE (L 1538), 2‐AMINO‐5‐PHENYL‐1: 3: 4‐THIADIAZOLE (L 1460) AND 2‐AMINO‐5‐(2‐THIENYL)‐1: 3: 4‐THIADIAZOLE (L 1458) [PDF]

British Journal of Pharmacology and Chemotherapy, 1958
The pharmacological actions of 5‐phenyl‐1: 3: 4‐thiadiazole (L 1538), 2‐amino‐5‐phenyl‐1: 3: 4‐thiadiazole (L 1460) and 2‐amino‐5‐(2′‐thienyl)‐1: 3: 4‐thiadiazole (L 1458) have been studied and compared with those of other muscular relaxant drugs. The three compounds have paralysing effects in mice, rats, cats, and dogs.
G, MAFFII, E, SONCIN
openaire   +2 more sources

Heterocyclizations based on N-(R-hydrazine-1-carbonothioyl)cycloalkancarboxamides: functionalized azoles and their antimicrobial activity

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Synthesis and structural modification of azoles remains an important area of medical chemistry and allows to obtain new compounds with a wide range of biological activity.
О. V. Kholodniak, Yu. V. Shubina, S. I. Kovalenko   +2 more
doaj   +1 more source

Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines

Journal of Taibah University for Science, 2022
One of the worst diseases, cancer claims millions of lives each year throughout the world, necessitating the creation of novel treatments. In this study, we designed a novel series of 1,3,4-thiadiazoles through the reaction of 2-(4-methyl-2-(2-(1 ...
Ghadah F. Aljohani, Tariq Z. Abolibda, Mohammad Alhilal, Jehan Y. Al-Humaidi, Suzan Alhilal, Hoda A. Ahmed, Sobhi M. Gomha   +6 more
doaj   +1 more source

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

Molecules, 2011
2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation
Kamal F. M. Atta, Omaima O.M. Farahat, Mohamed G. Marei, Alaa Z. A. Ahmed   +3 more
doaj   +1 more source

Synthesis and Evaluation of the Anti-Microbial Activity of New Heterocycles Containing the 1,3,4-Thiadiazole Moiety

Molecules, 2011
A new series of thiadiazole-enaminones 4 were synthesized via reactions of 5-acetyl-1,3,4-thiadiazoles 3 with dimethylformamide-dimethylacetal (DMF-DMA).
Thoraya A. Farghaly, Zienab A. Muhammad, Magda A. Abdallah   +2 more
doaj   +1 more source

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

A Nano-MgO and Ionic Liquid-Catalyzed 'Green' Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51). [PDF]

PLoS ONE, 2015
In this work, we describe the 'green' synthesis of novel 6-(adamantan-1-yl)-2-substituted-imidazo[2,1-b][1,3,4]thiadiazoles (AITs) by ring formation reactions using 1-(adamantan-1-yl)-2-bromoethanone and 5-alkyl/aryl-2-amino1,3,4-thiadiazoles on a nano ...
Sebastian Anusha, Baburajeev Cp, Chakrabhavi Dhananjaya Mohan, Jessin Mathai, Shobith Rangappa, Surender Mohan, Chandra, Shardul Paricharak, Lewis Mervin, Julian E Fuchs, Mahedra M, Andreas Bender, Basappa, Kanchugarakoppal S Rangappa   +13 more
doaj   +1 more source

Sustainable production and spectroscopic study of novel heterocyclic compounds synthesized from Carbendazim via green chemistry [PDF]

, 2023
In this research, a series of heterocyclic compounds with both five-membered and six-membered rings were synthesized. These compounds include oxadiazole, thiadiazol, thiazole, oxadiazine, thiadiazine, and triazine, among others.
Naif Murad Hassan, Adnan Othman Omar
core   +2 more sources