Results 111 to 120 of about 9,324,719 (299)
Synthesis and antimicrobial activity of some new pyrazolo[3,4-b] pyrazines and related heterocycles [PDF]
Assiut University Journal of Multidisciplinary Scientific Research, 2018 3-Methyl-1-phenyl-6-pyrrol-1-yl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid hydrazide (5) could be obtained in a four-step reaction starting from 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-4-carbonitrile 1.
doaj +1 more source
Copper-Catalyzed Three-Component Reaction of Alkynes, TMSN3, and Ethers: Regiocontrollable Synthesis of N1- and N2‑Oxyalkylated 1,2,3-Triazoles [PDF]
, 2019 A new copper-catalyzed selective synthesis of N1- and N2-oxyalkylated 1,2,3-triazoles has been developed through a three-component reaction of alkynes, TMSN3, and ethers. Through this methodology, a series of N1- and N2-oxyalkylated 1,2,3-triazoles could
Pengli Bao +11 more
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Regioselective synthesis of 4-fluoro-1,5-substituted-1,2,3-triazoles from synthetic surrogates of 1-fluoroalkynes [PDF]
, 2019 Here, we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount of trifloroacetic acid. This work provides the first regioselective method
Sampad, Jana +3 more
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Zaporožskij Medicinskij Žurnal, 2016 The aim of this work was the study of actoprotective activity of compounds, which combine sintons of 1,2,4-triazole-3-thiol and theophylline. Materials and methods.
A. S. Gotsulya
doaj
Zaporožskij Medicinskij Žurnal, 2015 The study of physical and chemical characteristics and establishing patterns of mass spectrometric fragmentation are the actual tasks of modern pharmaceutical science, have both scientific interest and practical importance. Aim.
V. A. Salionov +2 more
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A Multicomponent Electrosynthesis of 1,5-Disubstituted and 1‑Aryl 1,2,4-Triazoles [PDF]
, 2018 A novel electrochemical route has been developed for the synthesis of 1,5-disubstituted and 1-aryl 1,2,4-triazoles from aryl hydrazines, paraformaldehyde, NH4OAc, and alcohols.
Gaoqing Yuan (1652311), Na Yang (266025)
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Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges
Angewandte Chemie International Edition, EarlyView.Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley +1 more source
BMC MicrobiologyPotassium-competitive acid blockers (P-CABs), such as revaprazan (REV), act by competitively inhibiting potassium (K+) binding on the proton pump (H+/K+-ATPase) and are reversible K+ antagonists.
Wenxu Cheng +6 more
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1,2,3-Triazole N(2)-chelated C–S coupling: Access to ortho methylthiolated 1,2,3-triazoles [PDF]
, 2019 CuF2-mediated selective C-S coupling of 1,4-disubstituted 1,2,3-triazole halides using the widely available DMSO as the methylthiolation reagent were achieved through the chelation of N(2) atom in triazole ring. The ortho- C-halogen bond in N(1) aryl was
Yubo Jiang (4426555) +5 more
core +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015 The aim of research. Modern drugs must have certain characteristics, such as low toxicity and high efficiency. Special attention should be given to esthers of 2-(1,2,4-triazoles-3-iltio)acetic acids.
V. A. Salionov
doaj +1 more source