Results 101 to 110 of about 12,877,669 (294)

Synthesis and antimicrobial activity of some new pyrazolo[3,4-b] pyrazines and related heterocycles [PDF]

Assiut University Journal of Multidisciplinary Scientific Research, 2018
3-Methyl-1-phenyl-6-pyrrol-1-yl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid hydrazide (5) could be obtained in a four-step reaction starting from 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-4-carbonitrile 1.
doaj   +1 more source

Harnessing the β‑Silicon Effect for Regioselective and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization by Donor/Acceptor Carbenes Derived from 1‑Sulfonyl-1,2,3-triazoles

, 2018
The regioselective and enantioselective intermolecular sp3 C–H functionalization of silicon-substituted alkanes was accomplished using Rh2(S-NTTL)4 with readily available 1-sulfonyl-1,2,3-triazoles as carbene precursors.
Zachary J. Garlets (2734693), Huw M. L. Davies (1336170)   +1 more
core   +1 more source

Copper-Catalyzed Three-Component Tandem Reaction of Alkynes, α‑Diazo Esters, and TMSN₃ to Access N‑Substituted 1,2,3-Triazoles

, 2023
An efficient copper-catalyzed three-component tandem reaction of alkynes, α-diazo esters, and TMSN3 to construct triazoles has been developed. Through this strategy, a number of diverse N-substituted 1,2,3-triazoles were conveniently obtained in moderate
Yufen Lv (8823398), Zhiwei Wang (120259), Huilan Yue (4168288), Dong Yi (511609), Jindong Hao (8045717), Lianhui Song (17547402), Wei Wei (21173), Shuyun Zhu (1531012)   +7 more
core   +1 more source

Synthesis, bioevaluation and molecular docking study of new piperazine and amide linked dimeric 1,2,3-triazoles

, 2019
In search of more potent new antitubercular agents, a library of novel piperazine tethered dimeric 1,2,3-triazoles were designed by assembling 1,2,3-triazoles and piperazine in a single molecular architectural framework.
Jaiprakash N. Sangshetti (4842510), Tejshri R. Deshmukh (8051162), Vijay M. Khedkar (554344), Vagolu S. Krishna (8051168), Dharmarajan Sriram (816698), Bapurao B. Shingate (8051171), Smita P. Khare (8051165)   +6 more
core   +1 more source

Ein portalpräorganisiertes Cucurbit[7]uril‐Ruthenium‐Konjugat ermöglicht motivselektive Proteindetektion

Angewandte Chemie, EarlyView.
Die gezielte Veränderung der Erkennungsumgebung am Portal von Cucurbit[7]uril (CB7) wandelt einen Wirt ohne intrinsisches optisches Signal in einen motivselektiven photolumineszenten Rezeptor um. Das am Portal vororganisierte CB7‐Rubpy‐Konjugat zeigt Änderungen der Zugänglichkeit aromatischer Motive unmittelbar an und ermöglicht dadurch die optische ...
Patrick Gruhs, Albert Kraft, Vahideh Mahram, Marco Neumaier, Papri Chakraborty, Emily Janz, Maria Vittoria Balli, Pierre Picchetti, Luca Prodi, Manfred Kappes, Frank Biedermann   +10 more
wiley   +1 more source

Actoprotective properties of 7'-((3-thio-4-methyl-4H-1,2,4-triazole-5-yl)methyl)theophylline derivatives

Zaporožskij Medicinskij Žurnal, 2016
The aim of this work was the study of actoprotective activity of compounds, which combine sintons of 1,2,4-triazole-3-thiol and theophylline. Materials and methods.
A. S. Gotsulya
doaj  

Estudo da síntese espectros I.V. e atividade farmacobiológica de 1-acil-4-aril-tiosemicarbazidas e triazóis 3,4,5-trissubstituídos [PDF]

, 1987
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Curso de Pós-Graduação em Físico ...
Peres, Marize Terezinha Lopes Pereira
core  

“Click” synthesis of nonsymmetrical bis(1,2,3-triazoles)

, 2010
Unsymmetrically 1,1′-disubstituted 4,4′-bis-1H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a “double-click” strategy, two complementary approaches were implemented for the preparation of the key 4 ...
Balentová, Eva, Fratila, Raluca M., Azcune, Itxaso, Aizpurua, Jesús M., Miranda, José Ignacio, Sagartzazu-Aizpurua, Maialen   +5 more
core   +1 more source

In vitro combination effects and mechanisms of Revaprazan with Triazole antifungal drugs on Aspergillus

BMC Microbiology
Potassium-competitive acid blockers (P-CABs), such as revaprazan (REV), act by competitively inhibiting potassium (K+) binding on the proton pump (H+/K+-ATPase) and are reversible K+ antagonists.
Wenxu Cheng, Min Shen, Lijia Wan, Tian Chen, Lingxi Wang, Heng Zhang, Yi Sun   +6 more
doaj   +1 more source

ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles

, 2018
In the last years, we have investigated the click-chemical space covered by molecules containing the triazole ring and generated a database of 1,2,3-triazoles called ZINClick, starting from literature-reported alkynes and azides synthesizable in no more ...
Levré, Doriana, Mercalli, Valentina, Massarotti, Alberto, Alberto Massarotti, Doriana Levré, Chiara Arcisto, Valentina Mercalli (1520014), Alberto Massarotti (1520008), Arcisto, Chiara, Doriana Levré (6013466), Chiara Arcisto (6013469), Valentina Mercalli   +11 more
core   +1 more source