Results 81 to 90 of about 9,324,719 (299)

Pyridine C─N Transposition via Cycloaddition–Cycloreversion

Angewandte Chemie, EarlyView.
Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
wiley   +2 more sources

The research of acute toxicity of 4-amino-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Introduction. The process of new drugs creating includes a plurality of stages, which allow their application in medical practice in the future. These studies are a guarantee of the effectiveness and safety of the test compounds.
I. I. Аksyonova-Seliuk, Ye. S. Pruglo, O. I. Panasenko, Ye. G. Knysh   +3 more
doaj   +1 more source

ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles [PDF]

, 2018
In the last years, we have investigated the click-chemical space covered by molecules containing the triazole ring and generated a database of 1,2,3-triazoles called ZINClick, starting from literature-reported alkynes and azides synthesizable in no more ...
Levré, Doriana, Mercalli, Valentina, Massarotti, Alberto, Alberto Massarotti, Doriana Levré, Chiara Arcisto, Valentina Mercalli (1520014), Alberto Massarotti (1520008), Arcisto, Chiara, Doriana Levré (6013466), Chiara Arcisto (6013469), Valentina Mercalli   +11 more
core   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Nowadays an attempt to create a number of new biologically active compounds by many scientific groups is being one of the topical issues in the domestic pharmaceutical industry.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

Synthesis and Fluorescent Behaviour of 2‑Aryl-4,5-dihydro‑1H‑1,2,4-triazoles [PDF]

, 2016
A series of new 4,5-dihydro-1H-1,2,4-triazoles was synthesized from amidrazones and acetylenedicarboxylic acid esters in the presence of pyridine in toluene.
Olga O. Nesterenko (3564023), Enrico Benassi (1284723), Alexandra I. Eliseeva (3564017), Pavel A. Slepukhin (1489120), Nataliya P. Belskaya (3564020)   +4 more
core   +1 more source

Precision Switching and Coupled Motion in a [3]Rotaxane Molecular Machine

Angewandte Chemie, EarlyView.
A [3]rotaxane, composed by two crown ether macrocycles and an axle presenting three recognition sites, is operated through both chemical and electrochemical stimuli. The position of the macrocycles is precisely controlled by sequential stimulation and the processes are fully reversible. The characterization of the system revealed the macrocycles affect
Leonardo Andreoni, Jessica Groppi, Alberto Credi, Serena Silvi   +3 more
wiley   +2 more sources

Synthesis and physical-chemical properties of 3-alkylthio-5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dihydro-3H-1,2,4-triazoles

Zaporožskij Medicinskij Žurnal, 2016
The major social and economic problem of pharmaceutical industry is the search for biologically active substances, which may become the basis of new drugs, competitive with expensive imported drugs. Analysis of literature shows that in recent decades the
T. M. Kaplaushenko, O. I. Panasenko
doaj  

Access to Substituted Tricyclic Heteroarenes by an Oxidative Cyclization Reaction and Their Antifungal Performance

Pharmaceuticals
Background/Objectives: Fungal pathogens are increasingly developing concerning resistance against the currently available antifungal drugs, which creates a constant demand for new antifungal agents.
Rehema Nakiwala, Noopur Dasgupta, Rebecca Wilson, Erika I. Lutter, Jeanne L. Bolliger   +4 more
doaj   +1 more source

[3 + 2] Cycloaddition of Isocyanides with Aryl Diazonium Salts: Catalyst-Dependent Regioselective Synthesis of 1,3- and 1,5-Disubstituted 1,2,4-Triazoles [PDF]

, 2018
An unprecedented catalyst-dependent regioselective [3 + 2] cycloaddition of isocyanides with aryl diazonium salts is reported. 1,3-Disubstituted 1,2,4-triazoles were selectively obtained in high yield under Ag­(I) catalysis, whereas 1,5-disubstituted 1,2,
Xihe Bi, Xihe Bi (1457866), Xiang-Shan Wang (1632820), Xuanyu Shen (5873468), Xuanyu Shen, Jian-Quan Liu (3662470), Yihan Wang (668133), Jian-Quan Liu, Xiang-Shan Wang, Yihan Wang   +9 more
core   +1 more source