Results 61 to 70 of about 12,877,669 (294)

The combined action of ERG11 gene overexpression and its mutations in the development of Candida albicans resistance to triazolic antifungals

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Vitaly V. Zverev, Alexander D. Voropaev, Maxim S. Afanasiev, Elena A. Voropaeva, Elena V. Budanova, Ludmila M. Smirnova, Sofia A. Anisova, Yulia N. Urban   +9 more
doaj   +1 more source

Study of the Two Steps and One-Pot Two-Step Mechanochemical Synthesis of Annulated 1,2,4-Triazoles

, 2020
The mechanochemical synthesis of 1,2,4-triazoles by using a planetary ball-mill is studied starting from hydralazine hydrochloride. Excellent conditions were found for achieving total conversion to intermediate hydrazones in a few minutes in the presence
Michel Baron (3526049), Christiane André-Barrès (4407778), Brigitte Guidetti (8458623), Michel Baron, Brigitte Guidetti, Lori Gonnet, Michel Baltas, Alain Chamayou, Rachel Calvet, Alain Chamayou (8458626), Christiane André-Barrès, Lori Gonnet (3205602), Christophe Menendez (2342575), Rachel Calvet (8458629), Christophe Menendez, Michel Baltas (755384)   +15 more
core   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

Angewandte Chemie, EarlyView.
SOLiD‐MaP is a ligand‐directed photoproximity labeling strategy developed for RNA binding‐site analysis. Singlet oxygen‐mediated labeling creates a proximity‐dependent chemical footprint of bound small molecules on RNA. Coupling this chemistry with mutational profiling enables identification of the ligand‐binding region at nucleotide resolution ...
Lin L. Rietveld, Wei Wu, Filip M. Zawisza, Danny Incarnato, Zeshi Li   +4 more
wiley   +2 more sources

Analysis of natural and anthropogenic factors aff ecting the ability of Lepidium sativum L. to adapt to the toxicity of triazole xenobiotics [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология
The eff ects of natural factors (temperatures +34°C and +20°C) and anthropogenic xenobiotics (1,2,4-TriH; 1-(CH3 SO2 )-1H-1,2,4-Tri; 4-(PhSO2 )-4H-1,2,4-Tri; 4-(TolSO2 )-4H-1,2,4-Tri) on watercress Lepidium sativum L. was studied.
Isaichkin, Vadim A., Selezneva, Е. S., Belousova, Z. P.   +2 more
doaj   +1 more source

Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles [PDF]

مجلة التربية والعلم, 2009
In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Ethyl methacrylate was treated with hydrazine hydrate in ethanol to give the corresponding hydrazide (1).
Shereen R. Mohamed
doaj   +1 more source

Selective C(sp²)–H Halogenation of “Click” 4‑Aryl-1,2,3-triazoles

, 2017
Selective bromination reactions of “click compounds” are described. Electron-neutral and electron-deficient arenes selectively undergo unprecedented Pd-catalyzed C–H ortho-halogenations assisted by simple triazoles as modular directing groups, whereas ...
Asier Goitia (3728104), Enrique Gómez-Bengoa (1508548), Arkaitz Correa (1802245)   +2 more
core   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Analysis of the relationship between the predicted biological activity and the chemical structure of S-derivatives of 5-(5-bromofuran-2-yl)-4R-1,2,4-triazole-3-thiols

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021
1,2,4-Triazole derivatives are actively used as components in the development of new drugs, plant protection products, polymeric materials, anti-corrosion agents and etc.
O. A. Bigdan
doaj   +1 more source

Core and π‐Bridge Engineering to Deconstruct Y6‐Series into Modular Non‐Fused Acceptors: DFT‐Guided Structure‐Property Map for Organic Solar Cells

Advanced Electronic Materials, EarlyView.
The rigid fused backbone of Y6‐series acceptors is deconstructed into a modular, non‐fused A‐π‐A′‐π‐A architecture. Comprehensive quantum chemical simulations reveal that strategic core and π‐bridge engineering preserves strong near‐infrared light‐harvesting and enhances intramolecular charge‐transfer character.
Qurat ul Ain, Waqas Akram, Hasan Yaqoob, Munazza Shahid, Abdul Majid, Muhammad Altaf, Christian B. Nielsen, Raja Shahid Ashraf   +7 more
wiley   +1 more source