Results 221 to 230 of about 12,877,669 (294)

Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance. [PDF]

J Antimicrob Chemother
Gómez Londoño LF, Souza ACO, Burt B, Das S, Ge W, Meza-Perez V, Wiederhold NP, Shelat AA, Cuomo CA, Fortwendel JR, Rogers PD.   +10 more
europepmc   +1 more source

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

Rescuing TP53 from nonsense: novel triazoles for translational readthrough via optimized drug design. [PDF]

Sci Rep
Ricci D, Menditto M, Culletta G, Tutone M, Rizzo C, Pace A, Lentini L, Pibiri I.   +7 more
europepmc   +1 more source

Legacy hexaconazole and tricyclazole residues hinder organic transition in paddy rice cultivation

Agricultural &Environmental Letters, Volume 11, Issue 2, December 2026.
Hexaconazole and tricyclazole residues persisted in paddy soil throughout the three consecutive growing seasons after a single foliar application. These findings, combined with potential animal feed risks from contaminated rice straw, indicate that the current 2‐year organic transitional period is insufficient, necessitating extended conversion periods
Suin Cho, Hye‐In Joe, Tae‐Hwa Kim, Jong‐Woo Park, Byeong‐Jin Bae, Byeung‐Kon Shin, Jeong‐In Hwang   +6 more
wiley   +1 more source

Design, Synthesis, and Evaluation of New 1,4-Naphthoquinone-1,2,3-triazoles as Antimalarial Agents. [PDF]

Chem Biodivers
Rezainia L, Sayahi MH, Vernousfaderani EK, Mirfazli SS, Morshedsolouk MH, Dastyafteh N, Nateghpour M, Farivar L, Saeedi M, Hanifian H, Mohebali M, Shafiee SM, Hassanpour G, Mahdavi M.   +13 more
europepmc   +1 more source

Real‐World Survival Outcomes of Venetoclax Combination Therapies in Acute Myeloid Leukemia: Impact of Minimal Residual Disease Status and Antifungal Prophylaxis

Hematological Oncology, Volume 44, Issue 6, November 2026.
ABSTRACT In recent years the addition of the oral BCL2 inhibitor venetoclax to hypomethylating agents (HMAs) has emerged as the standard‐of‐care for patients with acute myeloid leukemia (AML) who are not fit for intensive chemotherapy, significantly improving survival and quality‐of‐life.
Mariarita Sciumè, Alessandro Bosi, Alfredo Marchetti, Fabio Serpenti, Pasquale De Roberto, Sonia Fabris, Francesco Versino, Elena Tagliaferri, Francesco Passamonti, Nicola Stefano Fracchiolla   +9 more
wiley   +1 more source

Effect of antifungal triazoles on vinca alkaloid neurotoxicity in pediatric patients: A retrospective case series analysis and literature review. [PDF]

Medicine (Baltimore)
Zhao Y, Ren X, Chen J, Zhu Y, Guo N, Zhang X, Huang L.   +6 more
europepmc   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Azole Resistance in <i>Aspergillus fumigatus</i> From Diverse Environments in Ohio, United States, Is Primarily Driven by TR₃₄/L98H and TR₄₆/Y121F/T289A Environmental Signatures. [PDF]

Open Forum Infect Dis
Paul RA, Sadhasivam S, Frey T, Miller SA, Paul PA, Lewis Ivey ML.   +5 more
europepmc   +1 more source