Identification and Cross-Characterisation of Artificial Promoters and 5′ Untranslated Regions in Vibrio natriegens [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Vibrio natriegens has recently gained attention as a novel fast-growing bacterium in synthetic biology applications. Currently, a limited set of genetic elements optimised for Escherichia coli are used in V.
Lisa Tietze +3 more
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Identification and Characterization of 5′ Untranslated Regions (5′UTRs) in Zymomonas mobilis as Regulatory Biological Parts [PDF]
Frontiers in Microbiology, 2017 Regulatory RNA regions within a transcript, particularly in the 5′ untranslated region (5′UTR), have been shown in a variety of organisms to control the expression levels of these mRNAs in response to various metabolites or environmental conditions ...
Seung Hee Cho +7 more
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Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes [PDF]
Genome BiologyBackground Untranslated regions (UTRs) are important mediators of post-transcriptional regulation. The length of UTRs and the composition of regulatory elements within them are known to vary substantially across genes, but little is known about the ...
Nechama Wieder +12 more
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Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. [PDF]
PLoS ONE, 2013 The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases.
Marcel Kramer +8 more
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Structural diversity and biological role of the 5’ untranslated regions of picornavirus [PDF]
RNA Biology, 2023 The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature.
Tingyu Peng +5 more
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Genetic polymorphisms of the 5' untranslated regions of the HSP70 gene in Indonesian cattle populations [PDF]
Veterinary World, 2022 Background and Aim: Heat shock proteins (HSPs) are a group of proteins that play a significant role in protecting cells against cellular stress. HSP70 is a conserved, sensitive, and abundant gene associated with heat stress's physiological adaptability ...
Peni Wahyu Prihandini +4 more
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eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions [PDF]
Frontiers in Molecular Biosciences, 2022 Translation initiation in eukaryotes is a multi-step pathway and the most regulated phase of translation. Eukaryotic initiation factor 3 (eIF3) is the largest and most complex of the translation initiation factors, and it contributes to events throughout
Andrei Stanciu +6 more
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Dengue and Zika Virus 5′ Untranslated Regions Harbor Internal Ribosomal Entry Site Functions [PDF]
mBio, 2019 The Flavivirus genus of the Flaviviridae family encompasses numerous enveloped plus-strand RNA viruses. Dengue virus (DENV), a flavivirus, is the leading cause of serious arthropod-borne disease globally.
Yutong Song +3 more
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The genomic features that affect the lengths of 5’ untranslated regions in multicellular eukaryotes [PDF]
BMC Bioinformatics, 2011 Background The lengths of 5’UTRs of multicellular eukaryotes have been suggested to be subject to stochastic changes, with upstream start codons (uAUGs) as the major constraint to suppress 5’UTR elongation.
Chen Feng-Chi +3 more
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RNP interfaces as regulatory “active sites”: a repurposing strategy for small molecules targeting viral 5′-untranslated regions [PDF]
Frontiers in Molecular BiosciencesRNA-protein (RNP) complexes regulate nearly every stage of gene expression and play central roles in viral infection and human disease. Despite decades of research, relatively few small molecules (SMs) have been shown to modulate RNP assemblies with ...
Louis G. Smith +7 more
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