Results 11 to 20 of about 231 (91)

An ameliorative protocol for the quantification of purine 5',8-cyclo-2'-deoxynucleosides in oxidized DNA [PDF]

Frontiers in Chemistry, 2015
5',8-Cyclo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2'-deoxyguanosine (cdG) are lesions resulting from hydroxyl radical (HO•) attack on the 5'H of the nucleoside sugar moiety and exist in both 5'R and 5'S diastereomeric forms.
Michael A. Terzidis, Chryssostomos eChatgilialoglu, Chryssostomos eChatgilialoglu   +2 more
doaj   +2 more sources

New Insights into the Reaction Paths of Hydroxyl Radicals with Purine Moieties in DNA and Double-Stranded Oligodeoxynucleotides. [PDF]

Molecules, 2019
The reaction of hydroxyl radical (HO•) with DNA produces many primary reactive species and many lesions as final products. In this study, we have examined the optical spectra of intermediate species derived from the reaction of HO• with a variety of ...
Chatgilialoglu C, Krokidis MG, Masi A, Barata-Vallejo S, Ferreri C, Terzidis MA, Szreder T, Bobrowski K.   +7 more
europepmc   +3 more sources

Effects of 5′,8′-Cyclo-2′-Deoxypurines on the Base Excision Repair of Clustered DNA Lesions in Nuclear Extracts of the XPC Cell Line

Cells, 2021
Clustered DNA lesions (CDL) containing 5′,8-cyclo-2′-deoxypurines (cdPus) are an example of extensive abnormalities occurring in the DNA helix and may impede cellular repair processes.
Julia Kaźmierczak-Barańska, Karolina Boguszewska, Michał Szewczuk, Bolesław T. Karwowski   +3 more
doaj   +1 more source

The Usefulness of Autoradiography for DNA Repair Proteins Activity Detection in the Cytoplasm towards Radiolabeled Oligonucleotides Containing 5′,8-Cyclo-2′-deoxyadenosine

Chemosensors, 2022
Autoradiography of 32P-radiolabeled oligonucleotides is one of the most precise detection methods of DNA repair processes. In this study, autoradiography allowed assessing the activity of proteins in the cytoplasm involved in DNA repair. The cytoplasm is
Karolina Boguszewska, Bolesław T. Karwowski, Julia Kaźmierczak-Barańska   +2 more
doaj   +1 more source

Biological Evaluation of DNA Biomarkers in a Chemically Defined and Site-Specific Manner. [PDF]

Toxics, 2019
As described elsewhere in this Special Issue on biomarkers, much progress has been made in the detection of modified DNA within organisms at endogenous and exogenous levels of exposure to chemical species, including putative carcinogens and ...
Bian K, Delaney JC, Zhou X, Li D.
europepmc   +3 more sources

A 5\u27, 8-cyclo-2\u27-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β. [PDF]

, 2014
5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation.
Chatgilialoglu, Chryssostomos, Jiang, Zhongliang, Lai, Yanhao, Liu, Yuan, Masi, Annalisa, Terzidis, Michael A., Xu, Meng   +6 more
core   +2 more sources

Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs [PDF]

, 2014
Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy.
Wang, Xin
core   +1 more source

Oxidative DNA damage modulates genome and epigenome integrity via base excision repair [PDF]

, 2021
Oxidative DNA damage is one of the leading causes of genome instability, cell death, and diseases. It is repaired by DNA base excision repair (BER), during which repair and translesion DNA polymerases may incorporate damaged nucleotides and mediate RNA ...
Tsegay, Pawlos S.
core   +1 more source

Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents [PDF]

, 2013
Fundamental study of enzymatic nucleoside transport suffers for lack of optical probes that can be tracked noninvasively. Nucleoside transporters are integral membrane glycoproteins that mediate the salvage of nucleosides and their passage across cell ...
Berdis, Anthony J., Choi, Jung-Suk, Deligonul, Nihal, Gray, Thomas G., Maity, Ayan, Teets, Thomas S.   +5 more
core   +4 more sources

Structures of (5′S)-8,5′-Cyclo-2′-deoxyguanosine Mismatched with dA or dT [PDF]

, 2013
pubs.acs.org ...
Allawi H. T., Arnott S., Ashis K. Basu, Bashford D., Belmadoui N., Birnbaum G. I., Boelens R., Borgias B. A., Borgias B. A., Boulard Y., Boussicault F., Brooks P. J., Brown T., Brown T., Bruker Biospin, Inc., Carbonnaux C., Case D. A., Chatgilialoglu C., Chatgilialoglu C., Chatgilialoglu C., Chen X., Chou S. H., Cooke M. S., Dedon P. C., Dirksen M. L., Dizdaroglu M., Dizdaroglu M., Dizdaroglu M., Frisch M. J., Fuciarelli A. F., Gao X., Gasparutto D., Geen H., Goddard T. D., Gorenstein D. G., Greene K. L., Griesinger C., Hai Huang, Haromy T. P., Huang H., Hunter W. N., James T. L., Jaruga P., Jaruga P., Jaruga P., Jaruga P., Jaruga P., Jasti V. P., Kan L. S., Karwowski B. T., Karwowski B. T., Karwowski B. T., Keck K., Keepers J. W., Kirkali G., Kirkali G., Kirkpatrick S., Lankhorst P. P., Lavery R., Lee J. H., Leonard G. A., Li Y., Liu H., Lu X. J., Malyshev D. A., Mariaggi N., Marion D., Markley J. L., Maskos K., McDowell J. A., Miaskiewicz K., Michael P. Stone, Navacchia M. L., Nikonowicz E. P., Nikonowicz E. P., Patel D. J., Patel D. J., Patel D. J., Piotto M., Prive G. G., Prive G. G., Rajat S. Das, Raleigh J. A., Reid B. R., Rodriguez H., Saenger W., Sahasrabudhe P. V., Salazar M., Tsui V., Wang H., Webster G. D.   +90 more
core   +3 more sources