Results 31 to 40 of about 134,788,912 (103)

DNA Damage Products (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines as Potential Biomarkers in Human Urine for Atherosclerosis

, 2016
We hypothesized that DNA damage products (5′R)-8,5′-cyclo-2′-deoxyadenosine (R-cdA) and (5′S)-8,5′-cyclo-2′-deoxyadenosine (S-cdA) may be well-suited biomarkers of risk and diagnosis for atherosclerosis.
Arkadiusz Jawien (2107438), Rafal Rozalski (433279), Pawel Jaruga (9759), Arkadiusz Migdalski (2107441), Miral Dizdaroglu (9761), Ryszard Olinski (433285)   +5 more
core   +1 more source

Solar one-way photoisomerisation of 5',8-cyclo-2'-deoxyadenosine

, 2008
Under sunlight irradiation (5'S)-5',8-cyclo-2'-deoxyadenosine 2 photoisomerises to the (5'R) isomer 1, which is the more easily repaired damage when these cyclopurine lesions are formed in ...
Miranda Miguel A, Jimenez Liliana B, Encinas Susana, Chatgilialoglu Chryssostomos   +3 more
core   +1 more source

A 5\u27, 8-cyclo-2\u27-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β. [PDF]

, 2014
5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation.
Chatgilialoglu, Chryssostomos, Masi, Annalisa, Liu, Yuan, Lai, Yanhao, Jiang, Zhongliang, Terzidis, Michael A., Xu, Meng, Xu Meng, Liu Yuan, Jiang Zhongliang, Terzidis Michael A, Chatgilialoglu Chryssostomos, Lai Yanhao, Masi Annalisa   +13 more
core   +1 more source

5',8-Cyclo-2'-deoxyadenosine (cdA) formation by γ-radiation. Theoretical quantum mechanics study [PDF]

, 2009
Reactions of reactive oxygen species and more specifically - of hydroxyl radical (•OH) - with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties.
Grand, Andre, Karwowski, Boleslaw, Cadet, Jean   +2 more
core  

Evidence for the Involvement of DNA Repair Enzyme NEIL1 in Nucleotide Excision Repair of (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines

, 2015
The DNA repair enzyme NEIL1 is a DNA glycosylase that is involved in the first step of base excision repair (BER) of oxidatively induced DNA damage. NEIL1 exhibits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6 ...
Pawel Jaruga (9759), Vladimir Vartanian (110280), Yan Xiao (91196), Miral Dizdaroglu (9761), R. Stephen Lloyd (110287)   +4 more
core   +1 more source

Induction of 8,5′-Cyclo-2′-deoxyadenosine and 8,5′-Cyclo-2′-deoxyguanosine in Isolated DNA by Fenton-Type Reagents

, 2016
Exposure of aqueous solutions of DNA to X- or γ-rays, which induces the hydroxyl radical as one of the major reactive oxygen species (ROS), can result in the generation of a battery of single-nucleobase and bulky DNA lesions. These include the (5′R) and (
Candace R. Guerrero (1331547), Jin Wang (29560), Yinsheng Wang (8699)   +2 more
core   +1 more source

Convenient synthesis of 8-amino-2′-deoxyadenosine [PDF]

, 2003
We studied the behaviour of 8-azido-2′-deoxyadenosine and 8-bromo-2′-deoxyadenosine in aqueous solutions of ammonia and primary and secondary amines. Unexpectedly, 8-Azido-2′-deoxyadenosine is converted to 8-amino-2′-deoxyadenosine in excellent yields ...
Eritja Casadellà, Ramón, Frieden, Miriam, Aviñó, Anna, Anna Avino, Miriam Frieden, Ramon Eritja   +5 more
core   +1 more source

Structure and Stability of Duplex DNA Containing (5′S)‑5′,8-Cyclo-2′-deoxyadenosine: An Oxidatively Generated Lesion Repaired by NER

, 2016
Cellular respiration and ionizing radiation generate 5′,8-cyclo-2′-deoxyribonucleosides, a special type of DNA damage that involves two modifications in the same nucleotide.
Tatiana Zaliznyak (2022349), Mark Lukin (2022352), Carlos de los Santos (2022355)   +2 more
core   +1 more source

Conversion of adenine and guanine bases to cyclo dA and cyclo dG bases.

, 2014
A, Formation of 2′-deoxyadenosine to (5′S) 8,5′-cyclo-2′-dA and (5′R) 8,5′-cyclo-2′-dA. B, Formation of 2′-deoxyguanosine to (5′S) 8,5′-cyclo-2′-dG and (5′R) 8,5′-cyclo-2′-dG.
Avvaru N. Suhasini (663612), Jochen Kuper (50292), Taraswi Banerjee (663613), Daniel L. Kaplan (663614), Caroline Kisker (50296), Irfan Khan (640146), Joshua A. Sommers (12889), Robert M. Brosh Jr (408931)   +7 more
core   +1 more source

Accumulation of (5 ` S)-8,5 `-cyclo-2 `-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice

, 2009
Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes.
de Souza-Pinto, Nadja C., SOUZA-PINTO, Nadja C. de, KIRKALI, Gueldal, BOHR, Vilhelm A., JARUGA, Pawel, DIZDAROGLU, Miral   +5 more
core   +1 more source