Results 31 to 40 of about 35,270,628 (98)

Cyclo-oxygenase inhibition reduces tumour growth and metastasis in an orthotopic model of breast cancer.

, 2002
The effect of selective and non-selective cyclo-oxygenase inhibition on tumour growth and metastasis in an orthotopic model of breast cancer was investigated.
Elizabeth M. Connolly (7958033), David J. Bouchier-Hayes (7958009), Graham Roche-Nagle (7958030), Judith Harmey (7895693), Tony O'Grady (7948508), Elaine Kay (7895411), Deirdre Foley (4422136)   +6 more
core   +4 more sources

8-amino(2-aminoethyl)-2'-deoxyadenosine incorporation into DNA by solid phase synthesis

, 1993
Solid phase synthesis of modified oligonucleotide 5 containing 8-amino(2-aminoethyl)-2'-deoxyadenosine unit is reported using trifluoroacetyl as a C8-side chain amino protector.
Parkash, T. P., Ganesh, K. N., T.P. Parkash, K.N. Ganesh   +3 more
core   +1 more source

Conversion of adenine and guanine bases to cyclo dA and cyclo dG bases.

, 2014
A, Formation of 2′-deoxyadenosine to (5′S) 8,5′-cyclo-2′-dA and (5′R) 8,5′-cyclo-2′-dA. B, Formation of 2′-deoxyguanosine to (5′S) 8,5′-cyclo-2′-dG and (5′R) 8,5′-cyclo-2′-dG.
Avvaru N. Suhasini (663612), Jochen Kuper (50292), Taraswi Banerjee (663613), Daniel L. Kaplan (663614), Caroline Kisker (50296), Irfan Khan (640146), Joshua A. Sommers (12889), Robert M. Brosh Jr (408931)   +7 more
core   +1 more source

A lipophilic “fully-anti” dodecamer from a (5'S)-5',8-cyclo-2'-deoxyguanosine

, 2014
The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated.
Silvia Pieraccini, MARIANI, Paolo, Chryssostomos Chatgilialoglu, Giovanna Fragneto, Stefano Masiero, Michael A. Terzidis, BALDASSARRI, ENRICO JUNIOR   +6 more
core   +2 more sources

The photochemistry of 8-bromo-2_-deoxyadenosine. A direct entry to cyclopurine lesions

, 2004
The UV photolysis of 8-bromo-2'-deoxyadenosine has been investigated in different solvents and in the presence of additives like halide anions. Photolytic cleavage of the C-Br bond leads to formation of the C8 radical.
Miguel A Miranda, Maria Luisa Navacchia, Chryssostomos Chatgilialoglu, Liliana B Jimenez, Susana Encinas   +4 more
core   +1 more source

Purine 5?,8-cyclo-2?-deoxynucleoside lesions in irradiated DNA

, 2016
Having their position gained among the smallest bulky DNA lesions recognized by the nucleotide excision repair (NER) enzyme, purine 5?,8-cyclo-2?-deoxynucleosides (5?,8-cPu) are increasingly attracting the interest in the field of genome integrity in ...
Chatgilialoglu C, Papadopoulos K, Terzidis MA, Krokidis MG   +3 more
core   +1 more source

Elevated urinary levels of 8-oxo-2 '-deoxyguanosine, (5 ' R)- and (5 ' S)-8,5 '-cyclo-2 '-deoxyadenosines, and 8-iso-prostaglandi F-2 alpha as potential biomarkers of oxidative stress in patients with prediabetes

, 2016
Prediabetes is the preclinical stage of type 2 diabetes mellitus (T2DM) with intermediate state of hyperglycemia. Hyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, beta-cell dysfunction ...
İŞLEKEL, GÜL HÜRAY, Kant, Melis, Akis, Merve, BAYRAKTAR, FIRAT, Calan, Mehmet, Arkan, Tugba, Dizdaroglu, Miral   +6 more
core   +1 more source

Mutagenicity and Genotoxicity of (5′S)‑8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)‑8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4

, 2015
Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG).
Ashis K. Basu (630373), Varsha Pednekar (1308057), Savithri Weerasooriya (630371), Vijay P. Jasti (630372)   +3 more
core   +1 more source

Oligodeoxynucleotides Containing N1-Methyl-2′-Deoxyadenosine and N6-Methyl-2′-Deoxyadenosine

, 2009
This unit describes a simple and efficient synthesis of the phosphoramidite derivative of N(1)-methyl-2'-deoxyadenosine from 2'-deoxyadenosine. The synthesis starts with the monomethoxytritylation of 2'-deoxyadenosine followed by methylation of 5'-O ...
Herdewijn, Piet, Timofeev, Edward, Roesch, Eric, Drenichev, Mikhail, Lemaitre, Marc, Mikhailov, Sergey, Efimtseva, Ekaterina   +6 more
core   +1 more source

Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies. [PDF]

Int J Mol Sci, 2023
Moccia M, Pascucci B, Saviano M, Cerasa MT, Terzidis MA, Chatgilialoglu C, Masi A.   +6 more
europepmc   +1 more source