Results 31 to 40 of about 8,065 (103)

Evidence for the Involvement of DNA Repair Enzyme NEIL1 in Nucleotide Excision Repair of (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines

, 2015
The DNA repair enzyme NEIL1 is a DNA glycosylase that is involved in the first step of base excision repair (BER) of oxidatively induced DNA damage. NEIL1 exhibits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6 ...
Pawel Jaruga (9759), Vladimir Vartanian (110280), Yan Xiao (91196), Miral Dizdaroglu (9761), R. Stephen Lloyd (110287)   +4 more
core   +1 more source

A 5\u27, 8-cyclo-2\u27-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β.

, 2014
5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation.
Chatgilialoglu, Chryssostomos, Masi, Annalisa, Liu, Yuan, Lai, Yanhao, Jiang, Zhongliang, Terzidis, Michael A., Xu, Meng   +6 more
core   +1 more source

Accumulation of (5 ` S)-8,5 `-cyclo-2 `-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice

, 2009
Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes.
de Souza-Pinto, Nadja C., SOUZA-PINTO, Nadja C. de, KIRKALI, Gueldal, BOHR, Vilhelm A., JARUGA, Pawel, DIZDAROGLU, Miral   +5 more
core   +1 more source

5',8-Cyclo-2'-deoxyadenosine (cdA) formation by γ-radiation. Theoretical quantum mechanics study

, 2009
Reactions of reactive oxygen species and more specifically - of hydroxyl radical (•OH) - with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties.
Grand, Andre, Karwowski, Boleslaw, Cadet, Jean   +2 more
core  

Elevated urinary levels of 8-oxo-2 '-deoxyguanosine, (5 ' R)- and (5 ' S)-8,5 '-cyclo-2 '-deoxyadenosines, and 8-iso-prostaglandi F-2 alpha as potential biomarkers of oxidative stress in patients with prediabetes

, 2016
Prediabetes is the preclinical stage of type 2 diabetes mellitus (T2DM) with intermediate state of hyperglycemia. Hyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, beta-cell dysfunction ...
İŞLEKEL, GÜL HÜRAY, Kant, Melis, Akis, Merve, BAYRAKTAR, FIRAT, Calan, Mehmet, Arkan, Tugba, Dizdaroglu, Miral   +6 more
core   +1 more source

Urinary 8-hydroxy-2′-deoxyguanosine levels are elevated in patients with IDH1-wildtype glioblastoma and are associated with tumor recurrence in gliomas

, 2023
2021 World Health Organization (WHO) Central Nervous System (CNS) Tumor Classification includes molecular diagnostic parameters such as isocitrate dehydrogenase (IDH) mutation or 1p19q codeletion status, in addition to the classical histological ...
İşlekel, GÜL HÜRAY, Bekar, Nazli Ecem Dal, Sertaç İşlekel, Nazlı Ecem Dal Bekar, İşlekel, Sertaç, Gül Hüray İşlekel, Tuna, Gamze, Bekar, Nazlı Ecem Dal, Gamze Tuna   +8 more
core   +1 more source

Mutagenicity and Genotoxicity of (5′S)‑8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)‑8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4

, 2015
Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG).
Ashis K. Basu (630373), Varsha Pednekar (1308057), Savithri Weerasooriya (630371), Vijay P. Jasti (630372)   +3 more
core   +1 more source

Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2'-deoxyadenosine.

, 2000
EHEB cells, a continuous cell line derived from a patient with B cell chronic lymphocytic leukemia (B-CLL), synthesized, when incubated with tritiated 2-chloro-2'-deoxyadenosine (CdA), labeled mono-, di-, and triphosphate ribonucleosides at a much higher
Cardoen, S, Bontemps, Françoise, Delacauw, A, Van den Berghe, Georges, Van Den Neste, Eric   +4 more
core   +1 more source

O protesto da CDA: aspectos tributários, administrativos e empresariais [PDF]

, 2014
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.Esta monografia tem o objetivo de estudar o protesto Extrajudicial de CDA - Certidão de Dívida Ativa sob os aspectos da legalidade e da conveniência para o ...
Falqueto, Jovelino
core  

2-chloro-2'-deoxyadenosine: Clinical applications in hematology

, 1996
The anticancer drug 2-chloro-2'-deoxyadenosine (CdA) belongs to the family of purine nucleoside analogs. CdA is exquisitely cytotoxic both to the dividing and to the non-dividing lymphocyte, which supports its use in lymphoproliferative disorders of low ...
Delannoy, André
core   +1 more source