Results 11 to 20 of about 245 (105)

Radiation-induced formation of purine lesions in single and double stranded DNA: revised quantification. [PDF]

Front Chem, 2015
The formation of oxidative lesions arising from double stranded DNA damage is of major significance to chemical biology from the perspective of application to human health.
Terzidis MA, Ferreri C, Chatgilialoglu C.   +2 more
europepmc   +4 more sources

Incorporation of 5',8-cyclo-2'deoxyadenosines by DNA repair polymerases via base excision repair. [PDF]

DNA Repair (Amst), 2022
Tsegay PS, Hernandez D, Brache C, Chatgilialoglu C, Krokidis MG, Chapagain P, Liu Y.   +6 more
europepmc   +2 more sources

New Insights into the Reaction Paths of Hydroxyl Radicals with Purine Moieties in DNA and Double-Stranded Oligodeoxynucleotides. [PDF]

Molecules, 2019
The reaction of hydroxyl radical (HO•) with DNA produces many primary reactive species and many lesions as final products. In this study, we have examined the optical spectra of intermediate species derived from the reaction of HO• with a variety of ...
Chatgilialoglu C, Krokidis MG, Masi A, Barata-Vallejo S, Ferreri C, Terzidis MA, Szreder T, Bobrowski K.   +7 more
europepmc   +3 more sources

Effects of 5′,8′-Cyclo-2′-Deoxypurines on the Base Excision Repair of Clustered DNA Lesions in Nuclear Extracts of the XPC Cell Line

Cells, 2021
Clustered DNA lesions (CDL) containing 5′,8-cyclo-2′-deoxypurines (cdPus) are an example of extensive abnormalities occurring in the DNA helix and may impede cellular repair processes.
Julia Kaźmierczak-Barańska, Karolina Boguszewska, Michał Szewczuk, Bolesław T. Karwowski   +3 more
doaj   +1 more source

The Usefulness of Autoradiography for DNA Repair Proteins Activity Detection in the Cytoplasm towards Radiolabeled Oligonucleotides Containing 5′,8-Cyclo-2′-deoxyadenosine

Chemosensors, 2022
Autoradiography of 32P-radiolabeled oligonucleotides is one of the most precise detection methods of DNA repair processes. In this study, autoradiography allowed assessing the activity of proteins in the cytoplasm involved in DNA repair. The cytoplasm is
Karolina Boguszewska, Bolesław T. Karwowski, Julia Kaźmierczak-Barańska   +2 more
doaj   +1 more source

The Effect of 8,5'-Cyclo 2'-deoxyadenosine on the Activity of 10-23 DNAzyme: Experimental and Theoretical Study. [PDF]

Int J Mol Sci
Cieślak M, Karwowski BT.
europepmc   +2 more sources

Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents [PDF]

, 2013
Fundamental study of enzymatic nucleoside transport suffers for lack of optical probes that can be tracked noninvasively. Nucleoside transporters are integral membrane glycoproteins that mediate the salvage of nucleosides and their passage across cell ...
Berdis, Anthony J., Choi, Jung-Suk, Deligonul, Nihal, Gray, Thomas G., Maity, Ayan, Teets, Thomas S.   +5 more
core   +4 more sources

A 5\u27, 8-cyclo-2\u27-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β. [PDF]

, 2014
5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation.
Chatgilialoglu, Chryssostomos, Jiang, Zhongliang, Lai, Yanhao, Liu, Yuan, Masi, Annalisa, Terzidis, Michael A., Xu, Meng   +6 more
core   +2 more sources

Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs [PDF]

, 2014
Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy.
Wang, Xin
core   +1 more source

Biomimetic Radical Chemistry and Applications [PDF]

, 2020
The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level.
Chatgilialoglu, Chryssostomos
core   +1 more source