Diastereomeric Recognition of 5’,8-cyclo-2’-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model [PDF]
Cells, 2019 5’,8-Cyclo-2’-deoxyadenosine (cdA), in the 5’R and 5’Sdiastereomeric forms, are typical non strand-break oxidative DNA lesions, induced by hydroxyl radicals, with emerging importance as a molecular marker.
Annalisa Masi +9 more
doaj +3 more sources
An ameliorative protocol for the quantification of purine 5',8-cyclo-2'-deoxynucleosides in oxidized DNA [PDF]
Frontiers in Chemistry, 2015 5',8-Cyclo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2'-deoxyguanosine (cdG) are lesions resulting from hydroxyl radical (HO•) attack on the 5'H of the nucleoside sugar moiety and exist in both 5'R and 5'S diastereomeric forms.
Michael A. Terzidis +2 more
doaj +3 more sources
The Effect of 8,5′-Cyclo 2′-deoxyadenosine on the Activity of 10-23 DNAzyme: Experimental and Theoretical Study [PDF]
International Journal of Molecular SciencesThe in vivo effectiveness of DNAzymes 10-23 (Dz10-23) is limited due to the low concentration of divalent cations. Modifications of the catalytic loop are being sought to increase the activity of Dz10-23 in physiological conditions.
Boleslaw Karwowski, Marcin Cieslak
exaly +3 more sources
Frontiers in Chemistry, 2015 The formation of oxidative lesions arising from double stranded DNA damage is of major significance to chemical biology from the perspective of application to human health.
Michael A. Terzidis +3 more
doaj +2 more sources
(5'S) 5',8-Cyclo-2'-Deoxyadenosine Cannot Stop BER. Clustered DNA Lesion Studies. [PDF]
Int J Mol Sci, 2021 As a result of external and endocellular physical-chemical factors, every day approximately ~105 DNA lesions might be formed in each human cell. During evolution, living organisms have developed numerous repair systems, of which Base Excision Repair (BER)
Karwowski BT.
europepmc +2 more sources
5',8-cyclo-dAdo and 8-oxo-dAdo DNA Lesions Are Both Substrates of Adenosine Deaminase: A Preliminary Study. [PDF]
CellsGenetic information, whether inside or outside the nucleus, is exposed to a variety of harmful physico-chemical factors. Although DNA damage repair systems have been extensively studied, little information about post-repair and non-genomic DNA damage ...
Karwowski BT.
europepmc +2 more sources
Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase η at atomic resolution. [PDF]
Proc Natl Acad Sci U S A, 2018 Oxidatively induced DNA lesions 8,5'-cyclopurine-2'-deoxynucleosides (cdPus) are prevalent and cytotoxic by impeding DNA replication and transcription. Both the 5'R- and 5'S-diastereomers of cdPu can be removed by nucleotide excision repair; however, the
Weng PJ +5 more
europepmc +2 more sources
EHA2021 Virtual Congress Abstract Book
, 2021 HemaSphere, Volume 5, Issue S2, June 2021.
wiley +1 more source
Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into Oligodeoxyribonucleotides
, 2016 Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into ...
Anthony Romieu (27583) +3 more
core +1 more source
A 5\u27, 8-cyclo-2\u27-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β. [PDF]
, 2014 5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation.
Chatgilialoglu, Chryssostomos +6 more
core +1 more source