The Influence of 5′,8-Cyclo-2′-deoxypurines on the Mitochondrial Repair of Clustered DNA Damage in Xrs5 Cells: The Preliminary Study [PDF]
Molecules, 2021 The 5′,8-cyclo-2′-deoxypurines (cdPus) affect the DNA structure. When these bulky structures are a part of clustered DNA lesions (CDL), they affect the repair of the other lesions within the cluster.
Karolina Boguszewska +2 more
doaj +2 more sources
Chemosensors, 2022 Autoradiography of 32P-radiolabeled oligonucleotides is one of the most precise detection methods of DNA repair processes. In this study, autoradiography allowed assessing the activity of proteins in the cytoplasm involved in DNA repair. The cytoplasm is
Karolina Boguszewska +2 more
doaj +2 more sources
Radiation-induced formation of purine lesions in single and double stranded DNA: Revised quantification [PDF]
Frontiers in Chemistry, 2015 The formation of oxidative lesions arising from double stranded DNA damage is of major significance to chemical biology from the perspective of application to human health.
Michael A. Terzidis +3 more
doaj +2 more sources
The Influence of Single, Tandem, and Clustered DNA Damage on the Electronic Properties of the Double Helix: A Theoretical Study [PDF]
Molecules, 2020 Oxidatively generated damage to DNA frequently appears in the human genome as the effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents, such as ionization radiation.
Bolesław T. Karwowski
doaj +2 more sources
Incorporation of 5’,8-Cyclo-2’Deoxyadenosines by DNA Repair Polymerases via Base Excision Repair [PDF]
DNA Repair, 2022 Prem P Chapagain +2 more
exaly +2 more sources
(5'S) 5',8-Cyclo-2'-Deoxyadenosine Cannot Stop BER. Clustered DNA Lesion Studies. [PDF]
Int J Mol Sci, 2021 As a result of external and endocellular physical-chemical factors, every day approximately ~105 DNA lesions might be formed in each human cell. During evolution, living organisms have developed numerous repair systems, of which Base Excision Repair (BER)
Karwowski BT.
europepmc +2 more sources
5',8-cyclo-dAdo and 8-oxo-dAdo DNA Lesions Are Both Substrates of Adenosine Deaminase: A Preliminary Study. [PDF]
CellsGenetic information, whether inside or outside the nucleus, is exposed to a variety of harmful physico-chemical factors. Although DNA damage repair systems have been extensively studied, little information about post-repair and non-genomic DNA damage ...
Karwowski BT.
europepmc +2 more sources
Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase η at atomic resolution. [PDF]
Proc Natl Acad Sci U S A, 2018 Oxidatively induced DNA lesions 8,5'-cyclopurine-2'-deoxynucleosides (cdPus) are prevalent and cytotoxic by impeding DNA replication and transcription. Both the 5'R- and 5'S-diastereomers of cdPu can be removed by nucleotide excision repair; however, the
Weng PJ +5 more
europepmc +2 more sources
EHA2021 Virtual Congress Abstract Book
, 2021 HemaSphere, Volume 5, Issue S2, June 2021.
wiley +1 more source
Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into Oligodeoxyribonucleotides
, 2016 Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into ...
Anthony Romieu (27583) +3 more
core +1 more source