Results 21 to 30 of about 8,065 (103)

The Influence of 5′,8-Cyclo-2′-deoxypurines on the Mitochondrial Repair of Clustered DNA Damage in Xrs5 Cells: The Preliminary Study [PDF]

Molecules, 2021
The 5′,8-cyclo-2′-deoxypurines (cdPus) affect the DNA structure. When these bulky structures are a part of clustered DNA lesions (CDL), they affect the repair of the other lesions within the cluster.
Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski   +2 more
doaj   +2 more sources

Effects of 5′,8′-Cyclo-2′-Deoxypurines on the Base Excision Repair of Clustered DNA Lesions in Nuclear Extracts of the XPC Cell Line

Cells, 2021
Clustered DNA lesions (CDL) containing 5′,8-cyclo-2′-deoxypurines (cdPus) are an example of extensive abnormalities occurring in the DNA helix and may impede cellular repair processes.
Julia Kaźmierczak-Barańska, Karolina Boguszewska, Michał Szewczuk, Bolesław T. Karwowski   +3 more
doaj   +2 more sources

The Usefulness of Autoradiography for DNA Repair Proteins Activity Detection in the Cytoplasm towards Radiolabeled Oligonucleotides Containing 5′,8-Cyclo-2′-deoxyadenosine

Chemosensors, 2022
Autoradiography of 32P-radiolabeled oligonucleotides is one of the most precise detection methods of DNA repair processes. In this study, autoradiography allowed assessing the activity of proteins in the cytoplasm involved in DNA repair. The cytoplasm is
Karolina Boguszewska, Bolesław T. Karwowski, Julia Kaźmierczak-Barańska   +2 more
doaj   +2 more sources

The Influence of Single, Tandem, and Clustered DNA Damage on the Electronic Properties of the Double Helix: A Theoretical Study [PDF]

Molecules, 2020
Oxidatively generated damage to DNA frequently appears in the human genome as the effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents, such as ionization radiation.
Bolesław T. Karwowski
doaj   +2 more sources

(5'S) 5',8-Cyclo-2'-Deoxyadenosine Cannot Stop BER. Clustered DNA Lesion Studies. [PDF]

Int J Mol Sci, 2021
As a result of external and endocellular physical-chemical factors, every day approximately ~105 DNA lesions might be formed in each human cell. During evolution, living organisms have developed numerous repair systems, of which Base Excision Repair (BER)
Karwowski BT.
europepmc   +2 more sources

Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair [PDF]

DNA Repair, 2022
Pawlos S Tsegay, Chryssostomos Chatgilialoglu, Marios G Krokidis   +2 more
exaly   +2 more sources

Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5'-deoxy-5-fluorocytidine (5'-DFCR). [PDF]

, 2021
BACKGROUND Pemetrexed (MTA) plus cisplatin combination therapy is considered the standard of care for patients with advanced non-small-cell lung cancer (NSCLC).
Yang, H., Peng, R.W., Gemperli, Camila Anna, Deng, Haibin, Wang, Wenxiang, Hall, Sean R R, Marti, T.M., Gao, Y., Su, M., Berezowska, S., Yang, Z., Dorn, Patrick, Xu, D., Schmid, Ralph Alexander, Marti, Thomas Michael, Hall, SRR, Berezowska, Sabina, Peng, Ren-Wang, Schmid, R.A., Gao, Yanyun, Xu, Duo, Gemperli, C.A., Deng, H., Dorn, P., Wang, W., Yang, Haitang, Su, Min, Zens, Philipp, Yang, Zhang, Zens, P.   +29 more
core   +1 more source

DNA Damage Products (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines as Potential Biomarkers in Human Urine for Atherosclerosis

, 2016
We hypothesized that DNA damage products (5′R)-8,5′-cyclo-2′-deoxyadenosine (R-cdA) and (5′S)-8,5′-cyclo-2′-deoxyadenosine (S-cdA) may be well-suited biomarkers of risk and diagnosis for atherosclerosis.
Arkadiusz Jawien (2107438), Rafal Rozalski (433279), Pawel Jaruga (9759), Arkadiusz Migdalski (2107441), Miral Dizdaroglu (9761), Ryszard Olinski (433285)   +5 more
core   +1 more source

Event-construal in press reports of violence in political protests: a cognitive linguistic approach to CDA [PDF]

, 2013
In this paper I extend the scope of the Cognitive Linguistic Approach to Critical Discourse Analysis (CDA) by incorporating Langacker’s model of Cognitive Grammar in a critical analysis of press reports of violence in two political protests. In doing so,
Hart, Christopher
core   +1 more source

Induction of 8,5′-Cyclo-2′-deoxyadenosine and 8,5′-Cyclo-2′-deoxyguanosine in Isolated DNA by Fenton-Type Reagents

, 2016
Exposure of aqueous solutions of DNA to X- or γ-rays, which induces the hydroxyl radical as one of the major reactive oxygen species (ROS), can result in the generation of a battery of single-nucleobase and bulky DNA lesions. These include the (5′R) and (
Candace R. Guerrero (1331547), Jin Wang (29560), Yinsheng Wang (8699)   +2 more
core   +1 more source